Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review John M McPartland, Marnie Duncan, Vincenzo Di Marzo and Roger G Pertwee British Journal of Pharmacology, 2015, 172, 737-753. Doi : 10.1111/bph.12944 Based upon evidence that the therapeutic properties of Cannabis preparations are not solely dependent upon the presence of Δ9-tetrahydrocannabinol (THC), pharmacological studies have been recently carried out with other plant cannabinoids (phytocannabinoids), particularly cannabidiol (CBD) and Δ9-tetrahydrocannabivarin (THCV). Results from some of these studies have fostered the view that CBD and THCV modulate the effects of THC via direct blockade of cannabinoid CB1 receptors, thus behaving like first-generation CB1 [...]
Lire la suiteThe Cannabis sativa Versus Cannabis indica Debate : An Interview with Ethan Russo, MD Daniele Piomelli and Ethan B. Russo Cannabis and Cannabinoid Research, 2016, Volume 1.1, 44-46. Doi : 10.1089/can.2015.29003.ebr Dr. Ethan Russo, MD, is a board-certified neurologist, psychopharmacology researcher, and Medical Director of PHYTECS, a biotechnology company researching and developing innovative approaches targeting the human endocannabinoid system. Previously, from 2003 to 2014, he served as Senior Medical Advisor and study physician to GW Pharmaceuticals for three Phase III clinical trials of Sativex for alleviation of cancer pain unresponsive to optimized opioid treatment and studies of Epidiolex for intractable epilepsy. He has held [...]
Lire la suiteIn vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa Ayat Zagzoog, Kawthar A. Mohamed, Hye Ji J. Kim, Eunhyun D. Kim, Connor S. Frank, Tallan Black, Pramodkumar D. Jadhav, Larry A. Holbrook & Robert B. Laprairie Scientific Reports, www.nature.com, 2020, 10, 20405, 1-13. Doi : 10.1038/s41598-020-77175-y The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of Δ9-tetrahydro-cannabinol (Δ9-THC) and cannabidiol (CBD), comparatively little is known about the pharmacology of the less-abundant plant-derived (phyto) cannabinoids. The best-studied transducers of cannabinoid-dependent effects are type 1 and type 2 cannabinoid receptors (CB1R, CB2R). Partial agonism of CB1R by Δ9-THC is [...]
Lire la suiteCannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis Mohamed M. Radwan, Suman Chandra, Shahbaz Gul and Mahmoud A. ElSohly Molecules, 2021, 26, 2774. Doi : 10.3390/molecules26092774 Abstract : Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents. More than 500 compounds have been reported from C. sativa, of which 125 cannabinoids have been isolated and/or identified as cannabinoids. Cannabinoids are C21 terpeno phenolic compounds specific to Cannabis. The non-cannabinoid constituents include: non-cannabinoid phenols, flavonoids, terpenes, alkaloids and others. This review discusses [...]
Lire la suiteAutorisation Temporaire Exceptionnelle d'Utilisation compassionelle du cannabis médical Laurent Appel (conseil en communication spécialisé en réduction des risques) 06.81.54.10.96 mailto : laurent.appel@asud.org relayé par www.Principesactifs.org, 26/03/2020 La chaine de soins et de médicament est en tension maximum. Le rôle de chacun est de détecter les failles actuelles et surtout futures pour éviter d'ajouter encore de la tension et faire tout sauter.Le cannabis médical peut jouer un rôle majeur tant comme solution thérapeutique alors que qon manque sera un facteur important de tensions. D'un point de vue médical, il va manquer aux patients déjà traités clandestinement et surtout au million de patients en automédication. Nous risquons donc avoir [...]
Lire la suiteTHCp – Newly discovered and highly potent phytocannabinoid Source : cannabislifenetwork.com Publié le 1 Fév 2020 We have discovered so much about cannabis over the years, but it’s vast, intricate, pharmacological map is missing many major regions. CBD dominant varieties have exploded in demand, yet the cannabinoid is still only partially understood, and there is still CBG and CBN just around the market’s corner. Now, brand new forms of THC and CBD, THCp and CBDp, respectively, have been discovered; evidence that the map’s expanse is still beyond our grasp. Phytocannabinoids over synthetics Lately, stories of newly discovered cannabinoids are strewn with the accomplishments of a biochemist [...]
Lire la suite6 variétés de cannabis pleines de THCV Aurélien BERNARD Newsweed.fr, 30 janvier 2020 https://www.newsweed.fr/5-varietes-cannabis-thcv/ À mesure que les connaissances scientifiques sur le cannabis se développent, la composition chimique du cannabis et la manière dont il interagit avec le corps se dévoilent. Et si le CBD ou le THC sont largement étudiés, certains cannabinoïdes plus rares comme le THCV (tetrahydocannabivarine) intéressent de plus en plus les scientifiques. Au cours de la dernière décennie, des études sur des humains et des animaux ont identifié le potentiel du THCV pour réduire l’appétit chez les personnes qui luttent pour perdre du poids, réguler la glycémie chez les personnes atteintes [...]
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