Comment les terpènes affectent les effets d’une variété de cannabis ? Publié le 12 mai 2020 NEWSWEED.fr , Par Aurélien BERNARD https://www.newsweed.fr/comment-terpenes-affectent-effets-variete-cannabis/ Lorsqu’on entend le mot terpène, la première idée qui vient à l’esprit est l’odeur d’une plante. La recherche scientifique a pourtant montré que les terpènes remplissent plus qu’une unique fonction sensorielle. Les terpènes produisent ainsi des effets spécifiques sur le corps, qu’ils soient anti-inflammatoires, antibactériens, relaxants ou anxiolytiques. C’est d’ailleurs aussi pour cette raison que certaines variétés procurent un sentiment de calme et de bien-être, alors que d’autres favorisent l’énergie. Les terpènes s’insèrent ainsi complètement dans l’effet d’entourage, qui suppose que les composants [...]
Lire la suiteEffet d’entourage contre douleur neuropathique Publié le 22 Mai 2020 https://www.principesactifs.org/effet-dentourage-contre-douleur-neuropathique/ Cette huile de cannabidiol est efficace contre la douleur neuropathique chronique, conclut cette étude pré-clinique de l’University of New Mexico (UNM). L’étude présentée dans la revue Life suggère que l’huile permet de diviser par 10 la sensibilité à la douleur mécanique et pendant plusieurs heures. Ici chez la souris modèle de douleur neuropathique postopératoire chronique. Ces données présentées dans la revue Life illustrent ce que les experts nomment l’effet d’entourage ou l’action synergique de différents composés du cannabis qui apporte cet effet thérapeutique. Dans cette expérience, il s’agit d’une huile de cannabis contenant [...]
Lire la suiteTerpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors David B. Finlay, Kathleen J. Sircombe, Mhairi Nimick, Callum Jones and Michelle Glass Frontiers in Pharmacology, 2020, Volume 11, Article 359, 1-9. doi : 10.3389/fphar.2020.00359 The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the plant have provoked research into the activity of minor chemical constituents of the plant—including volatile terpenoids such as myrcene, a- and b- pinene, b-caryophyllene, and limonene. However, to [...]
Lire la suiteA cross-sectional examination of choice and behavior of veterans with access to free medicinal cannabis Mallory J E Loflin, Kimberly Babson, James Sottile, Sonya B Norman, Staci Gruber, and Marcel O Bonn-Miller The American Journal of Drug and Alcohol Abuse, 2019, VOL. 45, NO. 5, 506–513. Doi : 10.1080/00952990.2019.1604722 ABSTRACT Background : With a rise in public pressure to increase veteran access to medicinal cannabis, free cannabis collectives for military veterans are proliferating across the US. Objectives : The aim of the current study was to document which cannabis formulations and routes of administration are chosen by veterans with increased access to cannabis, and to determine [...]
Lire la suiteComprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids Ramia Z. Al Bakain, Yahya S. Al-Degs, James V. Cizdziel and Mahmoud A. Elsohly Journal of Liquid Chromatography & Related Technologies, 2019 Doi : 10.1080/10826076.2019.1701015 ABSTRACT Different USA-origin cannabis samples were analyzed by GC-FID to quantify all possible cannabinoids and terpenoids prior to their clustering. Chromatographic analysis confirmed the presence of seven cannabinoids and sixteen terpenoids with variable levels. Among tested cannabinoids, D9-Tetrahydro-cannabinol D9-THC and cannabinol CBN were available in excess amounts (1.2–8.0 wt%) and (0.22–1.1 wt%), respectively. Fenchol was the most abundant terpenoid with a range of (0.03–1.0 wt%). [...]
Lire la suiteCannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients Jeffrey Y. Hergenrather, Joshua Aviram, Yelena Vysotski, Salvatore Campisi-Pinto, Gil M. Lewitus and David Meiri. Rambam Maimonides Medical Journal, 2020, 11, (1), e0001 Doi : 10.5041/RMMJ.10384 Methods : Participants were adult patients licensed for medical cannabis (MC) treatment who also reported a diagnosis of ADHD by a physician. Data on demographics, ADHD, sleep, and anxiety were collected using self-report questionnaires. Data collected on MC treatment included administration route, cultivator, cultivar name, and monthly dose. Comparison statistics were used to evaluate differences in reported parameters between low (20–30 g, n=18) and [...]
Lire la suiteMedicinal cannabis for psychiatric disorders: a clinically-focused systematic review Jerome Sarris, Justin Sinclair, Diana Karamacoska, Maggie Davidson and Joseph Firth BMC Psychiatry, 2020, 20, 24, 1-14. Doi : 10.1186/s12888-019-2409-8 Abstract Background : Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and intractable childhood epilepsy. Yet its potential application in the field of psychiatry is lesser known. Methods : The first clinically-focused systematic review on the emerging medical application of cannabis across all major psychiatric disorders was conducted. Current evidence regarding [...]
Lire la suiteMyorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD : A Randomized, Double-Blind Trial Aleksandra Nitecka-Buchta, Anna Nowak-Wachol, KacperWachol, KarolinaWalczynska-Dragon, Paweł Olczyk, Olgierd Batoryna, Wojciech Kempa and Stefan Baron Journal of Clinical Medicine, 2019, 8, 188, 1-17. doi : 10.3390/jcm8111886 Abstract Background : The healing properties of cannabidiol (CBD) have been known for centuries. In this study, we aimed to evaluate the efficiency of the myorelaxant effect of CBD after the transdermal application in patients with myofascial pain. Methods : The Polish version of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD Ia and Ib) was used. A total of 60 patients were enrolled [...]
Lire la suiteCannabis Oil : chemical evaluation of an upcoming cannabis-based medicine Luigi L. Romano, Arno Hazekamp Cannabinoids, 2013, 1, (1), 1-11 © International Association for Cannabinoid Medicines Abstract Concentrated cannabis extracts, also known as Cannabis oils because of their sticky and viscous appearance, are becoming increasingly popular among self-medicating patients as a claimed cure for cancer. In general, preparation methods for Cannabis oils are relatively simple and do not re-quire particular instruments. The most well-known example of such a product is called ‘Simpson oil’. The purpose of the extraction, often followed by a solvent evaporation step, is to make canna-binoids and other beneficial components such as [...]
Lire la suiteSalvia divinorum : from recreational hallucinogenic use to analgesic and anti-inflammatory action Ulises Coffeen, Francisco Pellicer Journal of Pain Research, 2019, Volume 12, 1069-1076 DOI: 10.2147/JPR.S188619 Abstract : Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with [...]
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