Synthetic cannabinoids and potential cardiac arrhythmia risk : an important message for drug users Jules C. Hancox, Nicola J. Kalk and Graeme Henderson Therapeutic Advances in Drug Safety, 2020, 11, 1-4. Doi : 10.1177/2042098620913416 Δ9-Tetrahydrocannabinol, the psychoactive ingredient in cannabis, and synthetic cannabinoid receptor agonists (SCRAs) activate the CB1 receptor to produce their profound behavioural effects and are widely used as recreational drugs. There is growing evidence that SCRAs, commonly known by the street name Spice or K2 (though there are many others, see: http://www.emcdda.europa.eu/publications/drug-profiles/synthetic-cannabinoids) can produce detrimental cardiovascular effects.(1) Commonly observed cardiotoxic effects of SCRAs include tachycardia, chest pain and hypertension.(1) However, bradycardia and [...]
Lire la suiteMarijuana use and coronary artery disease in young adults Jeremy R. Burt, Ali M. Agha, Basel Yacoub, Aryan Zahergivar, Julie Pepe PLoS ONE, 2020, 15, (1), e0228326, 1-8. Doi : 10.1371/journal.pone.0228326 Abstract Background Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use marijuana as compared to nonusers. Methods In this retrospective study, 1,420 patients with chest pain or angina equivalent were studied. Only men between 18 [...]
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