Cannabinoid CB1 and CB2 Receptor Signaling and Bias Mikkel Soes Ibsen, Mark Connor, Michelle Glass Cannabis and Cannabinoid Research, 2017, Volume 2.1, 48-60 https://doi.org/10.1089/can.2016.0037 Abstract An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in turn preferentially drive different downstream signaling cascades. This concept, termed “biased signaling” represents an exciting therapeutic opportunity to target specific pathways that elicit only desired effects, while avoiding undesired effects mediated by different signaling cascades. The cannabinoid receptors CB1 and CB2 each activate multiple pathways, [...]
Lire la suiteAn Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors Paula Morales and Patricia H. Reggio Cannabis and Cannabinoid Research, 2017, Volume 2.1, 265-273 DOI: 10.1089/can.2017.0036 Abstract The endocannabinoid system (ECS) has been shown to be of great importance in the regulation of numerous physiological and pathological processes. To date, two Class A G-protein-coupled receptors (GPCRs) have been discovered and validated as the main therapeutic targets of this system: the cannabinoid receptor type 1 (CB1), which is the most abundant neuromodulatory receptor in the brain, and the cannabinoid receptor type 2 (CB2), predominantly found in the immune system among other organs and tissues. Endogenous cannabinoid receptor [...]
Lire la suiteEndocannabinoid Signaling and Synaptic Function Pablo E. Castillo, Thomas J. Younts, Andres E. Chavez, and Yuki Hashimotodani Neuron, Cell Press, 2012. http://dx.doi.org/10.1016/j.neuron.2012.09.020 Endocannabinoids are key modulators of synaptic function. By activating cannabinoid receptors expressed in the central nervous system, these lipid messengers can regulate several neural functions and behaviors. As experimental tools advance, the repertoire of known endocannabinoid-mediated effects at the synapse, and their underlying mechanism, continues to expand. Retrograde signaling is the principal mode by which endocannabinoids mediate short- and long-term forms of plasticity at both excitatory and inhibitory synapses. However, growing evidence suggests that endocannabinoids can also signal in a nonretrograde manner. [...]
Lire la suiteIntroduction, 24e Journées du RESPADD "Usages thérapeutiques des cannabinoïdes", Session du GRECC, Docteur Christian Sueur, 26 juin 2019, Paris Bonjour Bienvenu à toutes et à tous Merci d’être venus aussi nombreux à ce premier colloque co-organisé par le GRECC et le RESPADD sur le thème du Cannabis Thérapeutique, ou, de façon « dépassionnée », sur les Usages Cliniques des Cannabinoïdes. Je veux tout d’abord remercier Nicolas Bonnet, Anne Borgne et le RESPADD de nous avoir invité à leur colloque annuel, de nous avoir donné offert cette première demie journée, et d’avoir invité de nombreux intervenants que nous avons proposés pour ces 2 jours de rencontres cannabiques. Le GRECC (Groupe de [...]
Lire la suiteN-Arachidonoyl Dopamine : A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities Urszula Grabiec and Faramarz Dehghani Cannabis and Cannabinoid Research, 2017, 2, (1), 183-196 DOI: 10.1089/can.2017.0015 Abstract N-arachidonoyl dopamine (NADA) is a member of the family of endocannabinoids to which several other N-acyldopamines belong as well. Their activity is mediated through various targets that include cannabinoid receptors or transient receptor potential vanilloid (TRPV)1. Synthesis and degradation of NADA are not yet fully understood. Nonetheless, there is evidence that NADA plays an important role in nociception and inflammation in the central and peripheral nervous system. The TRPV1 receptor, for which NADA is a [...]
Lire la suiteThe Clinical Significance of Endocannabinoids in Endometriosis Pain Management Jerome Bouaziz, Alexandra Bar On, Daniel S. Seidman, and David Soriano Cannabis and Cannabinoid Research, 2017, 2, 1, 72-80 DOI : 10.1089/can.2016.0035 Abstract Introduction : Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of pain is often insufficient and is associated with high rate of recurrence. Better pain management is therefore of urgent need. Methods : Among the various candidates, the endocannabinoid system (ECS) has recently emerged as a relevant pharmacological target for themanagement of endometriosis-related pain. [...]
Lire la suiteCannabinoids in Parkinson's Disease Mario Stampanoni Bassi, Andrea Sancesario, Roberta Morace, Diego Centonze, and Ennio Iezzi Cannabis and Cannabinoid Research, 2017, Volume 2.1 DOI: 10.1089/can.2017.0002 Abstract The endocannabinoid system plays a regulatory role in a number of physiological processes and has been found altered in different pathological conditions, including movement disorders. The interactions between cannabinoids and dopamine in the basal ganglia are remarkably complex and involve both the modulation of other neurotransmitters (c-aminobutyric acid, glutamate, opioids, peptides) and the activation of different receptors subtypes (cannabinoid receptor type 1 and 2). In the last years, experimental studies contributed to enrich this scenario reporting interactions between cannabinoids [...]
Lire la suiteRetrouvez l’ensemble des interventions des 24es Rencontres du RESPADD - GRECC : Utilisation cliniques des cannabinoïdes, juin 2019 Sarah LEJCZAK "Utilisation du Marinol en France : enquête auprès des prescripteurs" Roland TUBIANA et Fabienne CABY "Infection VIH et cannabinoïdes, état des lieux et pistes en recherche clinique" Allison McKIM : "Addicted to rehab : race, gender and drugs in the era of mass incarceration" Fabrice Olivet : "Races et drogues, les termes du sujet" François BAILLY : "Le cannabidiol en traitement "anti-addictif" chez les patients alcooliques : l'étude Caramel" Julien AZUAR "Usage de CBD et maladie psychiatrique" Pierre CHAMPY : "Cannabis sativa, plante médicinale en France ?" Jean-Michel [...]
Lire la suiteThe diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids : D9-tetrahydrocannabinol, cannabidiol and D9-tetrahydrocannabivarin Roger G. Pertwee British Journal of Pharmacology, 2008, 153, 199–215 doi:10.1038/sj.bjp.0707442 Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids or phytocannabinoids. This review focuses on the manner with which three of these compounds, (-)-trans-D9-tetrahydrocannabinol (D9-THC), (-)- cannabidiol (CBD) and (-)-trans-D9-tetrahydrocannabivarin (D9-THCV), interact with cannabinoid CB1 and CB2 receptors. D9-THC, the main psychotropic constituent of cannabis, is a CB1 and CB2 receptor partial agonist and in line with classical pharmacology, the responses it elicits appear to be strongly influenced both by [...]
Lire la suiteMolecular Targets of the Phytocannabinoids-A Complex Picture Paula Morales, Dow P. Hurst, Patricia H. Reggio Progress in the Chemistry of Organic Natural Products, 2017 ; 103: 103–131. doi:10.1007/978-3-319-45541-9_4. 1 Introduction For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. Phytocannabinoids are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis, including two compounds, (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC) and (−)-trans-Δ8-THC (Δ8-THC) that have been shown to bind to cannabinoid receptors and elicit the characteristic psychotropic effect associated with Cannabis [1]. [...]
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