Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin and glutamate systems William E. Fantegrossi, Cathryn D. Wilson, and Michael D. Berquist III Drug Metabolism Reviews, 2018, 50, (1), 65–73. doi : 10.1080/03602532.2018.1428343 Abstract An association between marijuana use and schizophrenia has been noted for decades, and the recent emergence of high-efficacy synthetic cannabinoids (SCBs) as drugs of abuse has lead to a growing number of clinical reports of persistent psychotic effects in users of these substances. The mechanisms underlying SCB-elicited pro-psychotic effects is unknown, but given the ubiquitous neuromodulatory functions of the endocannabinoid system, it seems likely that agonist actions at cannabinoid type-1 [...]
Lire la suiteBibliographie : Cannabinoïdes synthétiques et Néocannabinoïdes Dr Christian Sueur, GRECC, décembre 2020 Définitions et Usages des cannabinoïdes synthétiques : 2 - 6 Toxicologie des cannabinoïdes synthétiques : 7– 12 Cannabinoïdes synthétiques et psychose : 11 - 12 Pharmacologie des cannabinoïdes synthétiques : 13 - 16 Neurophysiologie des cannabinoïdes synthétiques : 17 -18 Analyse des cannabinoïdes synthétiques : 18 - 19 Usage médical des cannabinoïdes synthétiques : 20 – 22 Rimonabant : 21 -22
Lire la suiteSynthetic Pot : Not Your Grandfather’s Marijuana Benjamin M. Ford, Sherrica Tai, William E. Fantegrossi, and Paul L. Prather Trends in Pharmacological Sciences, 2017, 38, (3), 257–276. doi : 10.1016/j.tips.2016.12.003 Abstract In the early 2000’s in Europe and shortly thereafter in the USA, it was reported that “legal” forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB1 cannabinoid receptors, similar to those of Δ9-THC, the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to [...]
Lire la suiteLegal highs : staying on top of the flood of novel psychoactive substances David Baumeister, Luis M. Tojo and Derek K. Tracy Therapeutic Advances in Psychopharmacology, 2015, Vol. 5, (2), 97–132 DOI: 10.1177/2045125314559539 Abstract : There has been growing clinical, public, and media awareness and concern about the availability and potential harmfulness of so-called ‘legal highs’, which are more appropriately called new or novel psychoactive substances (NPS). A cat-and-mouse process has emerged wherein unknown chemists and laboratories are producing new, and as yet nonproscribed, compounds for human consumption; and as soon as they are banned, which they inevitably are, slightly modified analogues are produced to [...]
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