Investigation of Sex-Dependent Effects of Cannabis in Daily Cannabis Smokers Ziva D. Cooper and Margaret Haney Drug & Alcohol Dependence, 2014 March 1, 136, 85–91. doi :10.1016/j.drugalcdep.2013.12.013   Abstract Background—Women exhibit an accelerated progression from first cannabis use to cannabis use disorder (CUD) and show pronounced negative clinical issues related to CUD relative to men. Whether sex-dependent differences in cannabis’ direct effects contribute to the heightened risk in women is unknown. This analysis directly compared cannabis’ abuse-related subjective effects in men and women matched for current cannabis use. Methods—Data from four double-blind, within-subject studies measuring the effects of active cannabis (3.27–5.50% THC, depending on study) relative to [...]