Salvinorin A, a kappa-opioid receptor agonist hallucinogen : pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders Eduardo R. Butelman and Mary Jeanne Kreek Frontiers in Pharmacology, 2015 doi: 10.3389/fphar.2015.00190 Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the dynorphins) in higher functions, including cognition and perceptual effects. Salvinorin A is the only selective KOPr ligand to be widely available outside research or medical settings, and salvinorin A-containing products have undergone frequent nonmedical use. KOPr/dynorphin [...]
Lire la suiteHuman psychopharmacology and dose-effects of salvinorin A, a kappa-opioid agonist hallucinogen present in the plant Salvia divinorum Matthew W. Johnson, Katherine A. MacLean, Chad J. Reissig, Thomas E. Prisinzano and Roland R. Griffiths Drug and Alcohol Dependence, 2011, 115, (1-2), 150–155. doi: 10.1016/j.drugalcdep.2010.11.005 Abstract Salvinorin A is a potent, selective nonnitrogenous kappa opioid agonist and the known psychoactive constituent of Salvia divinorum, a member of the mint family that has been used for centuries by Mazatec shamans of Mexico for divination and spiritual healing. Salvia divinorum has over the last several years gained increased popularity as a recreational drug. This is a double-blind, placebo controlled [...]
Lire la suiteAcute and post-acute behavioral and psychological effects of salvinorin A in humans Peter H. Addy Psychopharmacology, 2012, 220, 195–204 DOI 10.1007/s00213-011-2470-6 Abstract Rationale : Salvia divinorum has been used for centuries, and nontraditional use in modern societies is increasing. Inebriation and aftereffects of use are poorly documented in the scientific literature. Objectives : This double-blind, placebo-controlled, randomized study analyzed subjective experiences of salvinorin A (SA) inebriation and consequences of use after 8 weeks. Methods : Thirty middle-aged, well-educated, hallucinogenexperienced participants smoked either 1,017 or 100μg SA 2 weeks apart in counterbalanced order. Vital signs were recorded before and after inhalation. A researcher rated participants' behavior during sessions. [...]
Lire la suiteLegally high ? Legal considerations of Salvia divinorum O. Hayden GRIFFIN III, Bryan Lee MILLER, David N. KHEYS Journal of Psychoactive Drugs, 2008, 40, (2), 183-190 In the past few years, there has been an apparent increase in the recreational use of Salvia divinorum. Its origins lie in the Mazatecan culture where its ceremonial use had historic ties to the traditional mystic religion and medicine practiced by its people. This psychoactive plant is native to the forest ravines of Oaxaca, Mexico--the area inhabited by the Mazatecs. It is a relative in the mint family, a family of plants that includes several psychoactive species. [...]
Lire la suiteCurrent perspectives on psychedelic therapy : use of serotonergic hallucinogens in clinical interventions Albert Garcia-Romeu and William A. Richards Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA INTERNATIONAL REVIEW OF PSYCHIATRY, 2018 https://doi.org/10.1080/09540261.2018.1486289 ABSTRACT Humans have used serotonergic hallucinogens (i.e. psychedelics) for spiritual, ceremonial, and recreational purposes for thousands of years, but their administration as part of a structured therapeutic intervention is still a relatively novel practice within Western medical and psychological frameworks. In the mid-20th century, considerable advances were made in developing therapeutic approaches integrating administration of low (psycholytic) and high (psychedelic) doses of serotonergic hallucinogens for treatment [...]
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