Efficacy and Safety of Intranasal Esketamine in Patients With Treatment-Resistant Depression and Comorbid Chronic Post-traumatic Stress Disorder : Open-Label Single-Arm Pilot Study Maud Rothärmel, Cherifa Benosman, Wissam El-Hage, Caroline Berjamin, Diane Ribayrol, Olivier Guillin, Raphaël Gaillard, Lucie Berkovitch and Virginie Moulier Frontiers in Psychiatry, 2022 | Volume 13 | Article 865466 doi : 10.3389/fpsyt.2022.865466 Abstract Introduction: Major depressive disorder (MDD) is more likely to resist to usual treatment when it is associated with post-traumatic stress disorder (PTSD). Capitalizing on the effect of ketamine in both treatment-resistant depression (TRD) and PTSD, we conducted a study in order to assess the efficacy of intranasal (IN) Esketamine in [...]
Lire la suiteBibliographie : "Substances psychédéliques et prise en charge des PTSD", Dr Christian Sueur, GRECC, mars 2023
Lire la suiteBibliographie MDMA - PTSD Dr Christian Sueur, mars 2023
Lire la suiteThe Efficacy of MDMA (3,4- Methylenedioxymethamphetamine) for Post- traumatic Stress Disorder in Humans : A Systematic Review and Meta-Analysis Sarah Tedesco , Ganeya Gajaram , Shahzad Chida , Arham Ahmad , Meghan Pentak , Marina Kelada , Layth Lewis , Deepa Krishnan , Carolyn Tran , Oladipo T. Soetan , Lawrance T. Mukona , Ayodeji Jolayemi Cureus, 13, (5), e15070. Doi : 10.7759/cureus.15070 Abstract Background : 3,4-methylenedioxymethamphetamine (MDMA), known recreationally as “Molly” or “Ecstasy”, is a triple monoamine reuptake inhibitor. MDMA specifically acts as a weak 5-HT1 and 5-HT2 receptor agonist, targeting 5-HT2A, 5-HT2B, and 5-HT2C receptors. Its potential use for therapeutic purposes with these pharmacological [...]
Lire la suiteCannabis and mental illness : a review Darby J. E. Lowe · Julia D. Sasiadek · Alexandria S. Coles · Tony P. George European Archives of Psychiatry and Clinical Neuroscience, 2018, 1-14. Doi : 10.1007/s00406-018-0970-7 Abstract With the increasing push to legalize cannabis in Western nations, there is a need to gage the potential impact of this policy change on vulnerable populations, such as those with mental illness, including schizophrenia, mood, and anxiety disorders. This is particularly important as there are strong motives in these individuals to seek short-term reward (e.g., “getting high”). Nonetheless, data to support the beneficial effects of cannabis use in psychiatric [...]
Lire la suiteTHREE NEW STUDIES ON CANNABIS AND PTSD Growing numbers of trauma sufferers are medicating with cannabis and finding it helpful. NATE SELTENRICH 31 décembre 2022 In recent years, psilocybin and MDMA have been explored as potential treatments for post-traumatic stress disorder, but somewhat more quietly so has cannabis. In fact, according to a few quick searches of PubMed, cannabis has a longer and richer association with PTSD in the scientific literature than any psychedelic. Though you wouldn’t know that by reading the headlines. Setting aside for a minute how effective psychedelics may or may not be as breakthrough treatments for PTSD, there’s no doubt that [...]
Lire la suitePosttraumatic stress disorder, sleep and medical cannabis treatment: A daily diary study Sharon R. Sznitman, David Meiri, Ben H. Amit, Dennis Rosenberg, Talya Greene Journal of Anxiety Disorders, 2022, 92, 102632 Doi : 10.1016/j.janxdis.2022.102632 Abstract Despite increasing use of Medical Cannabis (MC) among posttraumatic stress disorder(PTSD) patients, research is lacking on how MC treatment relates to PTSD symptomatology, in particular sleep disturbances. This study examines the time gap between MC use and sleep onset and its association with (1) number of awakenings throughout the night, (2) early awakenings, (3) nightmares. Each morning over a two week period, 77 licensed MC patients suffering from PTSD reported [...]
Lire la suiteAssessment of clinical outcomes in patients with post-traumatic stress disorder: analysis from the UK Medical Cannabis Registry Manaswini Pillai, Simon Erridge, Lara Bapir, Martha Nicholas, Nishaanth Dalavaye, Carl Holvey, Ross Coomber, Daniela Barros, Urmila Bhoskar, Gracia Mwimba, Kavita Praveen, Chris Symeon, Simmi Sachdeva-Mohan, James J Rucker and Mikael H Sodergren Expert Review of Neurotherapeutics, 2022, 22, 11–12, 1009–1018. Doi : 10.1080/14737175.2022.2155139 ABSTRACT Background : The current paucity of clinical evidence limits the use of cannabis-based medicinal products (CBMPs) in post-traumatic stress disorder (PTSD). This study investigates health-related quality of life (HRQoL) changes and adverse events in patients prescribed CBMPs for PTSD. Methods : A case-series of patients [...]
Lire la suiteIncreased cannabis intake during the COVID-19 pandemic is associated with worsening of depression symptoms in people with PTSD A. Murkar, T. Kendzerska, J. Shlik, L. Quilty, M. Saad and R. Robillard BMC Psychiatry, 2022, 22, 554 Doi : 10.1186/s12888-022-04185-7 Abstract Background: Some evidence suggests substance use affects clinical outcomes in people with posttraumatic stress disorder (PTSD). However, more work is required to examine links between mental health and cannabis use in PTSD during exposure to external stressors such as the COVID-19 pandemic. This study assessed mental health factors in individuals with self-reported PTSD to: (a) determine whether stress, anxiety, and depression symptoms were associ- ated with changes [...]
Lire la suiteLegalizing MDMA-Assisted Psychotherapy for the Treatment of Trauma-Related Mental Health Disorders Prakash THAMBIPILLAI Revue YOUR, 2021, Review 8, 51-61 3, 4–methylenedioxymethamphetamine, or MDMA as it is commonly known, is classified as a “Schedule 1” substance in Canada and the United States. For decades, the compound has been shrouded by the stigma of being a dangerous party drug thought to kill brain cells and be severely addictive. However, when it was originally discovered, it was experimentally used in clinical settings as an adjunct to therapy. This idea is now resurfacing as researchers are turning back to MDMA as an innovative way to treat trauma-related [...]
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