Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Robin L. Carhart-Harris, Robert Leech, David Erritzoe, Tim M. Williams, James M. Stone, John Evans, David J. Sharp, Amanda Feilding, Richard G. Wise, and David J. Nutt Schizophrenia Bulletin, 2012, Volume 39, Issue 6, November 2013, Pages 1343–1351 doi : 10.1093/schbul/sbs117 Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamo-cortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in 2 task-free resting-state scans. Primary analyses focused on [...]
Lire la suiteReduction in social anxiety after MDMA-assisted psychotherapy with autistic adults : a randomized, double-blind, placebo-controlled pilot study Alicia L. Danforth, Charles S. Grob, Christopher Struble, Allison A. Feduccia, Nick Walker, Lisa Jerome, Berra Yazar-Klosinski & Amy Emerson Psychopharmacology, 2018, https://doi.org/10.1007/s00213-018-5010-9 Abstract Rationale : Standard therapeutic approaches to reduce social anxiety in autistic adults have limited effectiveness. Since 3,4- methylenedioxymethamphetamine (MDMA)-assisted psychotherapy shows promise as a treatment for other anxiety disorders, a blinded, placebo-controlled pilot study was conducted. Objectives : To explore feasibility and safety ofMDMA-assisted psychotherapy for reduction of social fear and avoidance that are common in the autistic population. Methods : Autistic adults with marked to [...]
Lire la suitePsychedelic therapy for smoking cessation : Qualitative analysis of participant accounts Tehseen Noorani, Albert Garcia-Romeu, Thomas C. Swift, Roland R. Griffiths and Matthew W. Johnson Journal of Psychopharmacology, 2018, 1 –14 https://doi.org/10.1177/0269881118780 Abstract Background : Recent pilot trials suggest feasibility and potential efficacy of psychedelic-facilitated addiction treatment interventions. Fifteen participants completed a psilocybin-facilitated smoking cessation pilot study between 2009 and 2015. Aims : The aims of this study were as follows: (1) to identify perceived mechanisms of change leading to smoking cessation in the pilot study; (2) to identify key themes in participant experiences and long-term outcomes to better understand the therapeutic process. Methods : Participants were [...]
Lire la suiteSerotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease : A systematic review Simon Reiche, Leo Hermle, Stefan Gutwinskic Henrik Jungaberle, Peter Gasser, Tomislav Majić Progress in Neuropsychopharmacology & Biological Psychiatry, 2018, 81, 1–10 http://dx.doi.org/10.1016/j.pnpbp.2017.09.012 A B S T R A C T Anxiety and depression are some of the most common psychiatric symptoms of patients suffering with lifethreatening diseases, often associated with a low quality of life and a poor overall prognosis. 5-HT2A-receptor agonists (serotonergic hallucinogens, ‘psychedelics’) like lysergic acid diethylamide (LSD) and psilocybin were first investigated as therapeutic agents in the 1960s. Recently, after a long [...]
Lire la suiteDeveloping Guidelines and Competencies for the Training of Psychedelic Therapists Janis Phelps Journal of Humanistic Psychology, 2017, 1–38 DOI: 10.1177/0022167817711304 Abstract Research since the 1950s has shown that psychedelic-assisted psychotherapy has had significant positive effects in reductions of specific clinical symptoms and increases in quality of life as measured on a variety of indices. The intensity of focus on evidence-based outcomes, however, has resulted in a paucity of active discussions and research on the core competencies of the therapists themselves. The context of the history of psychedelic research reveals how this neglect of therapist variables occurred. With current discussions of Phase 3 and expanded access [...]
Lire la suiteIbogaine : A Novel Anti-Addictive Compound. A Comprehensive Literature Review Jonathan Freedlander Journal of Drug Education and Awareness, 2003 https://www.researchgate.net/publication/287670047_Ibogaine_A_novel_anti-addictive_compound Introduction and History Ibogaine is a naturally occurring indole alkaloid, found in a variety of African shrubs of the Tabernathe genus (Obach, Pablo, and Mash, 1998). The root of the Tabernanthe iboga plant (also known as eboga) is the most frequently cited source of ibogaine, and this plant contains 11 other known psychoactive constituents (Popik, and Skolnick, 1999). Chemically, ibogaine is classified as a tryptamine, being a rigid analogue of melatonin, and is structurally similar to harmaline, another natural alkaloid and psychedelic (Xu et al, [...]
Lire la suiteThe fourfold discovery of Mescaline (1896–1919) Ivo Gurschler Chemical Monthly, 2019, 150, 941–947 © Springer-Verlag GmbH Austria, part of Springer Nature 2019 https://doi.org/10.1007/s00706-019-02444-0 Abstract This is an historical account of the pharmacological, chemical, and anthropological research concerning the molecular makeup of the peyote cactus (Lophophora williamsii) that laid the ground for Ernst Spaeth’s structural elucidation of mescaline as 3,4,5-trimethoxyphenethylamine. Keywords : History of science · Psychedelic studies · Organic chemistry · Alkaloids · Mescaline · Drugs Introduction The exploration of the constituents of the peyote cactus and its effects upon the human psyche was an interdisciplinary undertaking that defied national borders. The material way to the heart of the [...]
Lire la suiteAyahuasca Scientific Papers AEDMP - Asociación para el Estudio y la Divulgación de la Medicina Psicodélica Research conducted by: Genís Oña -2013- Asociación para el Estudio y la Divulgación de la Medicina Psicodélica. Castellarnau, 11 2º 1ª 43004 Tarragona Spain Tel. 675 55 33 44 Email: medicina.psicodelica@hotmail.com www.medicinapsicodelica.org Content _____________________________________ 1. What is ayahuasca? 2. Scientific papers about ayahuasca arranged chronologically (1969-2013) - G. R. Dolmatoff (1969). El contexto cultural de un alucinógeno aborigen : Banisteriopsis Caapi - C. Grob et al. (1996). Human Psychopharmacology of Hoasca, a Plant Hallucinogen Used in Ritual Context in Brazil - J. C. Callaway et al. (1999). Pharmacokinetics of Hoasca Alkaloids in Healthy Humans - B. Shanon (2000). Ayahuasca and [...]
Lire la suitehttp://psychedelic-library.org/lsdmenu.htm Alas! the forbidden fruits were eaten, And thereby the warm life of reason congealed. A grain of wheat eclipsed the sun of Adam, Like as the Dragon's tail dulls the brightness of the moon. — Rumi: Masnavi I Ma'navi Introductory Papers The Exploration of Experience by: Humphrey Osmond, an excerpt from his 1957 paper "A Review of the Clinical Effects of Psychotomimetic Agents" Psychedelics, Technology, Psychedelics by: Bernard Aaronson and Humphry Osmond, the introductory chapter to PSYCHEDELICS, the Uses and Implications of Hallucinogenic Drugs Psychedelics and the Future by Humphry Osmond and Bernard S. Aaronson Request for a Public Hearing to: The Hearing Clerk, Department of Health, Education and Welfare Menus Psychotherapy and Psychedelic Drugs Psychedelic Research [...]
Lire la suitePeyote - Mescaline Scientific Papers AEDMP - Asociación para el Estudio y la Divulgación de la Medicina Psicodélica Research conducted by : Juan Spuch & Genís Oña Divulgación de la Medicina Psicodélica. Castellarnau, 11 2º 1ª 43004 Tarragona Spain Tel. 675 55 33 44 Email: medicina.psicodelica@hotmail.com www.medicinapsicodelica.org Content _____________________________________ 1. What is peyote? 2. Scientific papers about peyote - mescaline arranged chronologically (1954-2012) - H. Denber & S. Merlis (1954). A Note on Some Therapeutic Implications of the Mescaline induced State - C. Landis & J. Clausen (1954). Certain Effects of Mescaline and Lysergic Acid on Psychological Functions - J. Cattell (1954). The Influence of Mescaline on Psychodynamic Material - W. Frederking (1955). Intoxicant [...]
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