Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring Camille Hoffman, Sharon K. Hunter, Angelo D'Alessandro, KathleenNoonan et al. Psychological Medicine, 2019 Doi : https://doi.org/10.1017/S003329171900179X Published online by Cambridge University Press: 31 July 2019 Abstract Background : This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Methods : Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about [...]
Lire la suitePrenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone Roberto Frau, Vivien Miczán, Francesco Traccis, Sonia Aroni, Csaba I. Pongor, Pierluigi Saba, Valeria Serra, Claudia Sagheddu, Silvia Fanni, Mauro Congiu, Paola Devoto, Joseph F. Cheer, István Katona and Miriam Melis Nature Neuroscience, December 2019, VOL 22, 1975–1985 www.nature.com/natureneuroscience1975 Content courtesy of Springer Nature, terms of use apply. Rights reserved Doi : 10.1038/s41593-019-0512-2 The increased legal availability of cannabis has led to a common misconception that it is a safe natural remedy for, among others, pregnancy-related ailments such as morning sickness. Emerging clinical evidence, however, indicates that prenatal cannabis exposure (PCE) predisposes offspring to various neuropsychiatric [...]
Lire la suiteMay 10, 2019 Study will test pot’s effects on infants’ brain development Researchers seek to isolate cannabis from concurrent use of alcohol, tobacco, and illicit drugs. Media Contact: Brian Donohue - 206.543.7856, bdonohue@uw.edu Kleinhans Lab MRI scans of infants’ brains are part of the evaluation to discern effects of prenatal marijuana exposure. UW Medicine researchers are recruiting pregnant women to study whether prenatal marijuana use – in the absence of alcohol, tobacco, and any illicit drug consumption – affects their infants’ brain development, cognitive and motor development, medical health, and social behavior. The “Moms + Marijuana” study is co-led by Drs. Natalia Kleinhans and Stephen Dager, radiologists at [...]
Lire la suiteAssociation Between Marijuana Use and Adverse Obstetrical and Neonatal Outcomes CR Warshak; J Regan; B Moore; K Magner; S Kritzer; J Van Hook Journal of Perinatology, 2015, 35, 12, 991-995. PMID : 26401751 DOI : 10.1038/jp.2015.120 Abstract and Introduction Abstract Objective: To evaluate associations between marijuana exposure and adverse outcomes excluding women with polysubstance abuse and stratifying for concurrent maternal tobacco use. Study Design: We performed a retrospective cohort study evaluating various obstetrical and neonatal outcomes including: preterm delivery, pre-eclampsia, gestational diabetes, cesarean delivery, fetal growth restriction, a composite which included stillbirth or neonatal intensive care unit admission, and perinatal mortality. We stratified study groups [...]
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