A Chocolate a Day Keeps Depression Away ? Megan Brooks, Laurie Barclay Medscape, 13 / 09 /2019 https://www.medscape.org/viewarticle/917963 Clinical Context Accumulating evidence suggests that dietary factors, such as eating chocolate, may affect depressive symptoms. The potential mood-enhancing properties of chocolate may relate to its orosensory properties, psychoactive ingredients, and activation of neural reward pathways. However, only a few studies have analyzed associations between chocolate consumption and depressive symptoms, with conflicting results. The goal of this analysis was to evaluate associations between chocolate consumption and depressive symptoms in a large, representative sample of US adults enrolled in the US National Health and Nutrition Examination Survey (NHANES) between [...]
Lire la suitePrevalence and epidemiological associates of novel psychedelic use in the United States adult population James D. Sexton, Michael S. Crawford, Noah W. Sweat, Allyson Varley , Emma E. Green and Peter S. Hendricks Journal of Psychopharmacology, 1-10 DOI : 10.1177/0269881119827796 journals.sagepub.com/home/jopract Abstract Background : Novel psychedelics approximate classic psychedelics, but unlike classic psychedelics, novel psychedelics have been used by humans for a shorter period of time, with fewer data available on these substances. Aims : The purpose of this study was to determine the prevalence of novel psychedelic use and the associations of novel psychedelic use with mental health outcomes. Methods : We estimated the prevalence of self-reported, [...]
Lire la suiteComparison of the behavioral effects of mescaline analogs using the head twitch response in mice Adam L. Halberstadt, Muhammad Chatha, Stephen J. Chapman and Simon D. Brandt Journal of Psychopharmacology, 2019, 1 –9 DOI: 10.1177/0269881119826610 journals.sagepub.com/home/jop Abstract Background : In recent years, there has been increasing scientific interest in the effects and pharmacology of serotonergic hallucinogens. While a large amount of experimental work has been conducted to characterize the behavioral response to hallucinogens in rodents, there has been little systematic investigation of mescaline and its analogs. The hallucinogenic potency of mescaline is increased by α-methylation and by homologation of the 4-methoxy group but it not clear [...]
Lire la suiteDiscriminative Stimulus Effects of Psychostimulants and Hallucinogens in S()-3,4-Methylene-dioxy-meth amphetamine (MDMA) and R()-MDMA Trained Mice K. S. Murnane, N. Murai, L. L. Howell, and W. E. Fantegrossi THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, Vol. 331, No. 2 Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics 156174/3525473 JPET 331:717–723, 2009 Preliminary findings from these experiments were previously presented as follows : Murnane K.S., 2008 Expérimentalement Biology Meeting; San Diego, CA. doi:10.1124/jpet.109.156174. ABSTRACT 3,4-Methylenedioxymethamphetamine (MDMA) is a substituted phenethylamine more commonly known as the drug of abuse “ecstasy.” The acute and persistent neurochemical effects of MDMA in the mice are distinct from those in [...]
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