Totality of the Evidence Suggests Prenatal Cannabis Exposure Does Not Lead to Cognitive Impairments : A Systematic and Critical Review Ciara A. Torres, Christopher Medina-Kirchner, Kate Y. O'Malley and Carl L. Hardt Frontiers in Psychology, 2020, Vol 11, Art 816, 1-28. Doi : 10.3389/fpsyg.2020.00816 Background: Despite limited data demonstrating pronounced negative effects of prenatal cannabis exposure, popular opinion and public policies still reflect the belief that cannabis is fetotoxic. Methods: This article provides a critical review of results from longitudinal studies examining the impact of prenatal cannabis exposure on multiple domains of cognitive functioning in individuals aged 0 to 22 years. A literature search was [...]
Lire la suiteCannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats Ewa Kozela & Martyna Krawczyk & Tomasz Kos & Ana Juknat & Zvi Vogel & Piotr Popik Molecular Neurobiology, 2019, Doi : 10.1007/s12035-019-01831-2 Abstract Cannabidiol (CBD), a non-psychotropic cannabinoid, demonstrates antipsychotic-like and procognitive activities in humans and in animal models of schizophrenia. The mechanisms of these beneficial effects of CBD are unknown. Here, we examined behavioral effects of CBD in a pharmacological model of schizophrenia-like cognitive deficits induced by repeated ketamine (KET) administration. In parallel, we assessed transcriptional changes behind CBD activities in the prefrontal cortex (PFC), the [...]
Lire la suiteCannabis Exposure is Associated With a Lower Likelihood of Neurocognitive Impairment in People Living With HIV Caitlin Wei-Ming Watson, Emily W. Paolillo, Erin E. Morgan, Anya Umlauf, Erin E. Sundermann, Ronald J. Ellis, MD, Scott Letendre, Thomas D. Marcotte, Robert K. Heaton, and Igor Grant Journal of Acquired Immune Deficiency Syndromes, 2020, 83, (1), 56–64. Doi : 10.1097/QAI.0000000000002211 Background : Aging and HIV have adverse effects on the central nervous system, including increased inflammation and neural injury and confer risk of neurocognitive impairment (NCI). Previous research suggests the nonacute neurocognitive effects of cannabis in the general population are adverse or null. However, in the [...]
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