Future Directions for Clinical Psychedelic Research : The Relaxed Symptom Network Evan Lewis-Healey, Ruben Laukkonen , Michiel van Elk Pre-Print, May 2021 Doi : 10.31234/osf.io/q3ymd Abstract Recent clinical trials have demonstrated that psilocybin may have strong antidepressant effects, and may be effective in the treatment of depressive disorders when embedded in a psychotherapeutic protocol (psychedelic-assisted psychotherapy; PAP). There are now dozens of registered and ongoing clinical trials that intend to test for the efficacy of psilocybin within a psychotherapeutic protocol. Despite promising results, the mechanism(s) that may be responsible for the antidepressant effects of PAP are still hotly contested. In this paper, we provide a [...]