Cannabidiol as an add-on therapy to overcome the slow-onset and, possibly, resistance to antidepressant treatment : involvement of NAPE-PLD in the medial prefrontal cortex. Franciele F. Scarante, Vinícius D. Lopes, Eduardo J. Fusse, Maria A. Vicente, Melissa R. Araújo, Davi S. Scomparin, Rafael P. Aguiar, Francisco S. Guimarães, Viviani Nardinid, Carlos Arterio Sorgid, Lucia H. Faccioli, RhD, PhDd, Jaime E. C. Hallak, MD, PhDe,f; Samia Joca, Kenneth Mackie, Antonio Waldo Zuardi, José Alexandre S. Crippa, Alline C. Campos. bioRxiv preprint, April 26, 2021. doi : 10.1101/2021.04.23.441143 Highlights ● In mice, cannabidiol (CBD), but not escitalopram, induced a fast-onset anti-stress action. ● Combinations of sub-effective doses [...]
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