LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation Rainer Kraehenmann, Dan Pokorny, Helena Aicher, Katrin H. Preller, Thomas Pokorny, Oliver G. Bosch, Erich Seifritz and Franz X. Vollenweider Frontiers in Pharmacology, 2017, Volume 8, Article 814, 1-9. Doi : 10.3389/fphar.2017.00814 Rationale : Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking – an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces [...]
Lire la suiteClassic Hallucinogens and Mystical Experiences : Phenomenology and Neural Correlates Frederick S. Barrett, Roland R. Griffiths Current Topics in Behavioral Neurosciences, 2018, 36, 393–430. doi : 10.1007/7854_2017_474 Abstract This chapter begins with a brief review of descriptions and definitions of mystical-type experiences and the historical connection between classic hallucinogens and mystical experiences. The chapter then explores the empirical literature on experiences with classic hallucinogens in which claims about mystical or religious experiences have been made. A psychometrically validated questionnaire is described for the reliable measurement of mystical-type experiences occasioned by classic hallucinogens. Controlled laboratory studies show that under double-blind conditions that provide significant controls for [...]
Lire la suitePsilocybine mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects SMIGIELSKI Lukasz, SCHEIDEGGER Milan, KOMETER Michael, VOLLENWEIDER Franz X. NeuroImage, 2019, 196, 207-215 Doi : 10.1016/j.neuroimage.2019.04.009 A B S T R A C T Both psychedelics and meditation exert profound modulatory effects on consciousness, perception and cognition, but their combined, possibly synergistic effects on neurobiology are unknown. Accordingly, we conducted a randomized, double-blind, placebo-controlled study with 38 participants following a single administration of the psychedelic psilocybin (315 μg/kg p.o.) during a 5-day mindfulness retreat. Brain dynamics were quantified directly pre- and post-intervention by functional magnetic resonance imaging during the resting state and [...]
Lire la suiteThe Influence of Psychedelic Induced Ego-Dissolution on Self-Compassion, Kevin Allan Stansbury, 2019
The Influence of Psychedelic Induced Ego-Dissolution on Self-Compassion Kevin Allan Stansbury B.A., 2011, California State University, Dominguez Hills, May 2019 A THESIS Presented to the School of Social Work California State University, Long Beach In Partial Fulfillment of the Requirements for the Degree Master of Social Work Abstract Prior research has shown that psychedelic induced ego-dissolution mediates therapeutic outcomes and enhances well-being. The experience of psychedelics has been shown to increase certain mindfulness capacities. A cross-sectional descriptive study was implemented in an online community to examine the relationship between psychedelic induced ego-dissolution and self-compassion in adults who have used psychedelics in the past. This study also [...]
Lire la suiteClassic Hallucinogens and Mystical Experiences : Phenomenology and Neural Correlates Frederick S. Barrett and Roland R. Griffiths The following chapter will appear in the Springer text “Behavioral Neurobiology of Psychedelic Drugs”, in the series “Current Topics in Behavioral Neuroscience” that is edited by Adam L Halberstadt, Franz X Vollenweider, and David E Nichols Current Topics in Behavioral Neuroscience, 2017 March 26. DOI: 10.1007/7854_2017_474 Abstract This chapter begins with a brief review of descriptions and definitions of mystical-type experiences and the historical connection between classic hallucinogens and mystical experiences. The chapter then explores the empirical literature on experiences with classic hallucinogens in which claims about mystical or religious experiences [...]
Lire la suiteFour Weekly Ayahuasca Sessions Lead to Increases in “Acceptance” Capacities : A Comparison Study With a Standard 8-Week Mindfulness Training Program Joaquim Soler, Matilde Elices, Elisabeth Dominguez-Clavé, Juan C. Pascual, Amanda Feilding, Mayte Navarro-Gil, Javier García-Campayo and Jordi Riba Frontiers in Pharmacology, 2018, 9, 224. doi: 10.3389/fphar.2018.00224 Background : The therapeutic effects of the Amazonian plant tea ayahuasca may relate to its ability to enhance mindfulness capacities. Ayahuasca induces a modified state of awareness through the combined action of its active principles: the psychedelic N,N-dimethyltryptamine (DMT) and a series of centrally acting b-carbolines, mainly harmine and tetrahydroharmine. To better understand the therapeutic potential of [...]
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