Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring Camille Hoffman, Sharon K. Hunter, Angelo D'Alessandro, KathleenNoonan et al. Psychological Medicine, 2019 Doi : https://doi.org/10.1017/S003329171900179X Published online by Cambridge University Press: 31 July 2019 Abstract Background : This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Methods : Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about [...]