Perceived outcomes of psychedelic microdosing as self-managed therapies for mental and substance use disorders Toby Lea & Nicole Amada & Henrik Jungaberle & Henrike Schecke & Norbert Scherbaum & Michael Klein Psychopharmacology, 2020. Di : 10.1007/s00213-020-05477-0 Abstract Rationale : The regular consumption of very small doses of psychedelic drugs (known as microdosing) has been a source of growing media and community attention in recent years. However, there is currently limited clinical and social research evidence on the potential role of microdosing as therapies for mental and substance use disorders. Objectives : This paper examined subjective experiences of microdosing psychedelics to improve mental health or to cease [...]
Lire la suitePersisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic psychedelic Use : An Online Survey Albert Garcia-Romeu, Alan K. Davis, Earth Erowid, Fire Erowid, Roland R. Griffiths and Matthew W. Johnson Frontiers in Psychiatry, 2020, Vol 10, Article 955. Doi : 10.3389/fpsyt.2019.00955 Background : Observational data and preliminary studies suggest serotonin 2A agonist psychedelics may hold potential in treating a variety of substance use disorders (SUDs), including opioid use disorder (OUD). Aims : The study aim was to describe and analyze self-reported cases in which naturalistic psychedelic use was followed by cessation or reduction in other substance use. Methods : An anonymous online survey of [...]
Lire la suiteMicrodosing psychedelics: Demographics, practices, and psychiatric comorbidities Daniel Rosenbaum, Cory Weissman, Thomas Anderson, Rotem Petranker, Le-Anh Dinh-Williams, Katrina Hui and Emma Hapke Journal of Psychopharmacology, 2020, 1-11. doi.org/10.1177/0269881120908004 Abstract Rationale : Microdosing psychedelics – the practice of consuming small, sub-hallucinogenic doses of substances such as LSD or psilocybin – is gaining attention in popular media but remains poorly characterized. Contemporary studies of psychedelic microdosing have yet to report the basic psychiatric descriptors of psychedelic microdosers. Objectives : To examine the practices and demographics of a population of psychedelic microdosers – including their psychiatric diagnoses, prescription medications, and recreational substance use patterns – to develop a foundation [...]
Lire la suitePsychedelics and Psychedelic-Assisted Psychotherapy Collin M. Reiff, M.D., Elon E. Richman, M.D., Charles B. Nemeroff, M.D., Ph.D., Linda L. Carpenter, M.D., Alik S. Widge, M.D., Ph.D., Carolyn I. Rodriguez, M.D., Ph.D., Ned H. Kalin, M.D., William M. McDonald, M.D., and the Work Group on Biomarkers and Novel Treatments, a Division of the American Psychiatric Association Council of Research AJP in Advance, 2019, 1-20. doi: 10.1176/appi.ajp.2019.19010035 Objective : The authors provide an evidenced-based summary of the literature on the clinical application of psychedelic drugs in psychiatric disorders. Methods : Searches of PubMed and PsycINFO via Ovid were conducted for articles in English, in peer-reviewed journals, reportingon“psilocybin,” [...]
Lire la suiteBibliographie : "Microdosing" thérapeutique de substances psychédéliques Docteur Christian SUEUR, GRECC, février 2020.
Lire la suiteSerotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music Frederick S. Barrett, Katrin H. Preller, Marcus Herdener, Petr Janata and Franz X. Vollenweider Cerebral Cortex, November 2018, 28, 3939–3950. doi : 10.1093/cercor/bhx257 Abstract Classic psychedelic drugs (serotonin 2A, or 5HT2A, receptor agonists) have notable effects on music listening. In the current report, blood oxygen level-dependent (BOLD) signal was collected during music listening in 25 healthy adults after administration of placebo, lysergic acid diethylamide (LSD), and LSD pretreated with the 5HT2A antagonist ketanserin, to investigate the role of 5HT2A receptor signaling in the neural response to the time-varying tonal [...]
Lire la suiteRole of the 5-HT2A Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States : A Pharmacological fMRI Study Katrin H. Preller, Leonhard Schilbach, Thomas Pokorny, Jan Flemming, Erich Seifritz, and Franz X. Vollenweider The Journal of Neuroscience, 2018, 38, (14), 3603–3611. Doi : 10.1523/JNEUROSCI.1939-17.2018 Distortions of self-experience are critical symptoms of psychiatric disorders and have detrimental effects on social interactions. In light of the immense need for improved and targeted interventions for social impairments, it is important to better understand the neurochemical substrates of social interaction abilities. We therefore investigated the pharmacological and neural correlates of self- and other-initiated social interaction. In [...]
Lire la suiteReported effects of psychedelic use on those with low well-being given various emotional states and social contexts Natasha L. Mason, Patrick C. Dolder and Kim P.C. Kuypers Drug Science, Policy and Law, 2020, Volume 6, 1–11. Doi : 10.1177/2050324519900068 Abstract Background : It has been suggested that the outcome of the psychedelic experience is dependent on set and setting. While scientific research into the therapeutic potential of psychedelics is growing, it is clear that in clinical populations an optimal set and setting will not always be attainable. It was aimed to assess under which emotional and environmental circumstances psychedelic users use psychedelics, and the outcome [...]
Lire la suiteTherapeutic Use of LSD in Psychiatry : A Systematic Review of Randomized-Controlled Clinical Trials Juan José Fuentes, Francina Fonseca, Matilde Elices, Magí Farré and Marta Torrens Frontiers in Psychiatry, 2020, Vol 10, Article 943. doi : 10.3389/fpsyt.2019.00943 Lysergic acid diethylamide (LSD) was studied from the 1950s to the 1970s to evaluate behavioral and personality changes, as well as remission of psychiatric symptoms in various disorders. LSD was used in the treatment of anxiety, depression, psychosomatic diseases and addiction. However, most of the studies were not performed under contemporary standards, and it has taken several decades for a resurgence of interest in LSD research and [...]
Lire la suiteTherapeutic Potential of Psychedelic Drugs Justin Briglio University of Maine, 2015, 31 p. Table of Contents Introduction......................................................................................................................................3 History of Psychedelic Research.....................................................................................................6 Recent Research...............................................................................................................................8 Neurobiology of Psychedelics.........................................................................................................9 Therapeutic Potential of Psilocybin...............................................................................................12 Therapeutic Potential of LSD........................................................................................................15 Therapeutic Potential of Ayahuasca..............................................................................................19 Therapeutic Potential of Ibogaine..................................................................................................22 Conclusion.....................................................................................................................................26 References......................................................................................................................................28 A psychedelic compound is a psychoactive drug whose main action is to alter perception and cognition. Psychedelics are distinctive from other psychoactive drugs in that they alter the mind, whereas opiates or stimulants alter the mood (Meyer & Quenzer, 2013). Psychedelics affect nature of consciousness itself and access otherwise unknown states of consciousness, as opposed to affecting the degree or extent of one's consciousness and inducing proverbial moods such as [...]
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