BIBLIOGRAPHIE : Salvia Divinorum: Pharmacologie, Neurophysiologie, usages thérapeutiques… Docteur Christian SUEUR, GRECC, mai 2020 1 - Salvia Divinorum : généralités : 1 - 3 2 - Salvia Divinorum et Neurophysiologie : 4 – 6 3 - Salvinorin A et Pharmacologie : 7 - 10 4 - Salvia Divinorum et Chamanisme : 11 5 - Salvia Divinorum et Psychiatrie : 12 6 - Salvia Divinorum et Thérapeutique : 13 - 14
Lire la suiteA spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C. Pimenta, Igor Dimitri Gama Duarte and Maria Elena de Lima Journal of Venomous Animals and Toxins including Tropical Diseases, 2016, 22, 34, Doi : 10.1186/s40409-016-0091-6 Abstract Background : Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in its action [...]
Lire la suiteEmerging Evidence for Cannabis’ Role in Opioid Use Disorder Beth Wiese and Adrianne R. Wilson-Poe Cannabis and Cannabinoid Research, 2018, Volume 3.1,179-189. Doi : 10.1089/can.2018.0022 Abstract Introduction : The opioid epidemic has become an immense problem in North America, and despite decades of research on the most effective means to treat opioid use disorder (OUD), overdose deaths are at an all-time high, and relapse remains pervasive. Discussion : Although there are a number of FDA-approved opioid replacement therapies and maintenance medications to help ease the severity of opioid withdrawal symptoms and aid in relapse prevention, these medications are not risk free nor are they successful for [...]
Lire la suiteFrom local to global—Fifty years of research on Salvia divinorum Ivan Casselman, Catherine J. Nock, Hans Wohlmuth, Robert P. Weatherby, Michael Heinrich Journal of Ethnopharmacology, 2014, 151, 768–783 http://dx.doi.org/10.1016/j.jep.2013.11.032 a b s t r a c t Ethnopharmacological relevance : In 1962 ethnopharmacologists, Hofmann and Wasson, undertook an expedition to Oaxaca,Mexico. These two researchers were the first scientists to collecta flowering specimen of Salvia divinorum allowing theidentification ofthisspecies.Whilet he species'traditional use is confined to a very small region of Mexico, since Hofmann and Wasson's expedition 50 years ago, Salvia divinorum has become globally recognized for its main active constituent, the diterpene salvinorin A, which has [...]
Lire la suiteDose-related Effects of Salvinorin A in Humans : Dissociative, Hallucinogenic, and Memory Effects MacLEAN K.A., JOHNSON M.W., REISSIG C.J., PRISINZANO T.E., GRIFFITHS R.R. : Psychopharmacology (Berl), 2013, 226, (2), 381–392. doi: 10.1007/s00213-012-2912-9 Abstract Rationale—Salvinorin A is a kappa opioid agonist and the principal psychoactive constituent of the plant Salvia divinorum, which has increased in popularity as a recreational drug over the past decade. Few human studies have examined salvinorin A. Objective—This double-blind, placebo-controlled study evaluated the dose-related effects of inhaled salvinorin A in individuals with histories of hallucinogen use. Methods—Eight healthy hallucinogen-using adults inhaled up to 16 doses of salvinorin A (0.375 - 21 μg/kg) in ascending order. Physiological, behavioral, [...]
Lire la suiteSalvinorin A : Pharmacology, therapeutic potential and structural considerations of a unique non-nitrogenous selective k-opioid receptor agonist, and active component of the sage Salvia divinorum. Adriano Ciaffoni Graduate School of Life Sciences, Utrecht University July 2014, Utrecht, The Netherlands Summary Salvia divinorum is a plant indigenous of Oaxaca, Mexico. Traditionally, the plant is used for healing and divinatory purposes. At present, S. divinorum is also used recreationally by teenagers and young adults around the world. The main active component is salvinorin A, a unique non-nitrogenous kappa-opioid receptor agonist with hallucinogenic properties. Scientific interest is high, due to two facts: 1) salvinorin A was the first [...]
Lire la suiteSalvinorin A, a kappa-opioid receptor agonist hallucinogen : pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders Eduardo R. Butelman and Mary Jeanne Kreek Frontiers in Pharmacology, 2015 doi: 10.3389/fphar.2015.00190 Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the dynorphins) in higher functions, including cognition and perceptual effects. Salvinorin A is the only selective KOPr ligand to be widely available outside research or medical settings, and salvinorin A-containing products have undergone frequent nonmedical use. KOPr/dynorphin [...]
Lire la suiteHuman psychopharmacology and dose-effects of salvinorin A, a kappa-opioid agonist hallucinogen present in the plant Salvia divinorum Matthew W. Johnson, Katherine A. MacLean, Chad J. Reissig, Thomas E. Prisinzano and Roland R. Griffiths Drug and Alcohol Dependence, 2011, 115, (1-2), 150–155. doi: 10.1016/j.drugalcdep.2010.11.005 Abstract Salvinorin A is a potent, selective nonnitrogenous kappa opioid agonist and the known psychoactive constituent of Salvia divinorum, a member of the mint family that has been used for centuries by Mazatec shamans of Mexico for divination and spiritual healing. Salvia divinorum has over the last several years gained increased popularity as a recreational drug. This is a double-blind, placebo controlled [...]
Lire la suiteAcute and post-acute behavioral and psychological effects of salvinorin A in humans Peter H. Addy Psychopharmacology, 2012, 220, 195–204 DOI 10.1007/s00213-011-2470-6 Abstract Rationale : Salvia divinorum has been used for centuries, and nontraditional use in modern societies is increasing. Inebriation and aftereffects of use are poorly documented in the scientific literature. Objectives : This double-blind, placebo-controlled, randomized study analyzed subjective experiences of salvinorin A (SA) inebriation and consequences of use after 8 weeks. Methods : Thirty middle-aged, well-educated, hallucinogenexperienced participants smoked either 1,017 or 100μg SA 2 weeks apart in counterbalanced order. Vital signs were recorded before and after inhalation. A researcher rated participants' behavior during sessions. [...]
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