Bibliographie Cannabis et Cannabinoïdes en Neurologie Docteur Christian SUEUR, GRECC, avril 2020. Cannabinoïdes et Sclérose en Plaque, p 4. Cannabinoïdes et Migraines, p 7. Cannabinoïdes et maladies neurodégénératives, p 8. Cannabinoïdes et Maladie de Parkinson, p 10. Cannabinoïdes et Maladie de Huntington, p 11. Cannabinoïdes et Maladie d’Alzheimer, p 12.
Lire la suitePreclinical and Clinical Evidence Supporting Use of Cannabidiol in Psychiatry Gioacchino Calapai, Carmen Mannucci, Ioanna Chinou, Luigi Cardia, Fabrizio Calapai, Emanuela Elisa Sorbara, Bernardo Firenzuoli, Valdo Ricca, Gian Franco Gensini and Fabio Firenzuoli Hindawi - Evidence-Based Complementary and Alternative Medicine, 2019, Article ID 2509129, 11 pages https://doi.org/10.1155/2019/2509129 Background : Cannabidiol (CBD) is a major chemical compound present in Cannabis sativa. CBD is a nonpsychotomimetic substance, and it is considered one of the most promising candidates for the treatment of psychiatric disorders. Objective. &e aim of this review is to illustrate the state of art about scientific research and the evidence of effectiveness of CBD [...]
Lire la suiteEndocannabinoid System in Neurological Disorders (Endocannabinoid System and Neurodegeneration) Roberta Ranieri, Chiara Laezza, Maurizio Bifulco, Daniela Marasco and Anna Maria Malfitano Recent Patents on CNS Drug Discovery, 2015, Vol. 10, No. 2, 24 p. Abstract : Background : Several studies support the evidence that the endocannabinoid system and cannabimimetic drugs might have therapeutic potential in numerous pathologies. These pathologies range from neurological disorders, atherosclerosis, stroke, cancer to obesity/metabolic syndrome and others. Methods : In this paper we review the endocannabinoid system signaling and its alteration in neurodegenerative disorders like multiple sclerosis, Alzheimer’s disease, Parkinson’s disease and Huntington’s disease and discuss the main findings about the use [...]
Lire la suitePriority Considerations for Medicinal Cannabis-Related Research Marcel O. Bonn-Miller, Charles V. Pollack, Jr., David Casarett, Richard Dart, Mahmoud ElSohly, Larry Good, Manuel Guzman, Lumır Hanus, Kevin P. Hill, Marilyn A. Huestis, Eric Marsh, Susan Sisley, Nancy Skinner, Judith Spahr, Ryan Vandrey, Eugene Viscusi, Mark A. Ware, and Donald Abrams Cannabis and Cannabinoid Research, 2019, Volume 4, Number 3, 1-19. DOI: 10.1089/can.2019.0045 Keywords : medicinal cannabis; medical marijuana Introduction and Rationale The National Academy of Sciences, Engineering, and Medicine’s 2017 publication The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research provided a significant contribution by synthesizing the existing evidence base [...]
Lire la suiteCB 2 Cannabinoid Receptors as a Therapeutic Target - What does the Future Hold ? Amey Dhopeshwarkar and Ken Mackie Molecular Pharmacology, 2014, 86, 430–437 http://dx.doi.org/10.1124/mol.114.094649 ABSTRACT The past decades have seen an exponential rise in our understanding of the endocannabinoid system, comprising CB1 and CB2 cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes that synthesize and degrade endocannabinoids. The primary focus of this review is the CB2 receptor. CB2 receptors have been the subject of considerable attention, primarily due to their promising therapeutic potential for treating various pathologies while avoiding the adverse psychotropic effects that can accompany CB1 receptor–based therapies. With the appreciation that [...]
Lire la suiteThe neuroprotection of cannabidiol against MPP+-induced toxicity inPC12 cells involves trkA receptors, upregulation of axonal and synapticproteins, neuritogenesis, and might be relevant to Parkinson's disease Neife Aparecida Guinaim Santos, Nádia Maria Martins, Flávia Malvestio Sisti, Laís Silva Fernandes, Rafaela Scalco Ferreira, Regina Helena Costa Queiroz, Antônio Cardozo Santos Toxicology in Vitro, 2015, 30, 231–240. http://dx.doi.org/10.1016/j.tiv.2015.11.004 a b s t r a c t Cannabidiol (CBD) is a non-psychoactive constituent of Cannabis sativa with potential to treat neurodegenerative diseases. Its neuroprotection has beenmainly associated with anti-inflammatory and antioxidant events; however, other mechanisms might be involved. We investigated the involvement of neuritogenesis, NGF receptors (trkA), NGF, and [...]
Lire la suiteBibliographie CANNABINOIDES et Maladies Neurodégénératives Dr Christian Sueur, GRECC, avril 2019 (2e édition). ALTAMURA C. et al. : Elevation of Plasma 2 –Arachidonoylglycerol Levels in Alzheimer’s Disease Patients as a Potential Protective Mechanism against Neurodegenerativ Decline, Journal of Alzheimer Disease, 2015, 46, 2, 497-506. ASO E., SANCHEZ-PLA A., VEGAS-LOZANO, MALDONADO R., FERRER I. : Cannabis-based medicine reduces multiple pathological process in AβPP/PS1 mice, Journal of Alzheimer’s Disease, 2015, 43, 977-991. ASO E. et al. : Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model, Journal of Alzheimer Disease, 2016, 54, 3, 903-912. BISOGNO T., ODDI S., PICCOLI [...]
Lire la suitehttps://www.canada.ca/fr/sante-canada/services/drogues-medicaments/cannabis/renseignements-medecins/renseignements-destines-professionnels-sante-cannabis-cannabinoides.html Renseignements destinés aux professionnels de la santé : Le cannabis (marijuana, marihuana) et les cannabinoïdes (Version PDF - 2,690 Ko) Plante séchée ou fraîche et huile destinées à l'administration par ingestion ou par d'autres moyens Agent psychoactif Le présent document a été préparé par la Direction générale de la légalisation et réglementation du cannabis de Santé Canada pour fournir des renseignements sur l'usage du cannabis (marihuana) et des cannabinoïdes à des fins médicales. Le présent document est un résumé d'articles scientifiques examinés par les pairs et de revues internationales sur les utilisations thérapeutiques possibles et sur les effets néfastes du cannabis et des [...]
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