Powerful substances in tiny amounts: Exploring the practice of microdosing psychedelic drugs Petter Grahl Johnstad, Pré-Print, 2017. This article presents an explorative study of microdosing practices with psychedelic drugs. A microdose is defined as a sub-perceptual dose, commonly about one tenth of an ordinary recreational dose, which gives no alteration of consciousness or feeling of intoxication. Respondents (n = 17) were recruited at several Internet fora for individual interviews mediated via private messaging. Every participant was male, and the median respondent was in his 30s with a stable job and relationship and extensive entheogen experience. Respondents tended to experiment with microdosing in phases, [...]
Lire la suiteMedical Cannabis Use Rising Among Older Adults Pauline Anderson Medscape Medical News ©March 22, 2021 More individuals are using medical cannabis, but the increase appears to be more pronounced among seniors, new research suggests. Results of a large Canadian survey study show that the proportion of older users among total users increased from 17.6% before 2017 to 26.7% in 2018 and 31.2% in 2019. The proportion of older users was 22.7% in 2020, but there were fewer participants in this latest sample (8869 in 2019 and 5644 in 2020). The majority of older respondents reported that they use cannabis to relieve pain and prefer cannabidiol [...]
Lire la suitePositive expectations predict improved mental-health outcomes linked to psychedelic microdosing, KAERTNER L.S., STEINBORN M.B., KETTNER H., SPRIGGS M.J., ROSEMAN L., BUCHBORN T., BALAET M., TIMMERMANN C., ERRITZOE D., CARHARDT-HARRIS R.L. : Nature, 2021, 11, 1941 Doi : 1038/s41598-021-81446-7 Abstract Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo-controlled studies failed to find compelling evidence for this. The present study collected web-based mental health and related data using a prospective (before, during and after) design. Individuals planning a weekly microdosing regimen completed surveys at strategic [...]
Lire la suiteThe association between cannabis use and mood disorders : A longitudinal study Daniel Feingold, Mark Weiser, Jürgen Rehme, Shaul Lev-Ran Journal of Affective Disorders, 2015, 172, 211–218. doi : 10.1016/j.jad.2014.10.006 a b s t r a c t Background : The association between cannabis use and mood disorders is well documented, yet evidence regarding causality is conflicting. This study explored the association between cannabis use, major depressive disorder (MDD) and bipolar disorder (BPD) in a 3-year prospective study. Methods : Data was drawn from waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). MDD and BPD were controlled at baseline [...]
Lire la suiteCannabis Exposure is Associated With a Lower Likelihood of Neurocognitive Impairment in People Living With HIV Caitlin Wei-Ming Watson, Emily W. Paolillo, Erin E. Morgan, Anya Umlauf, Erin E. Sundermann, Ronald J. Ellis, MD, Scott Letendre, Thomas D. Marcotte, Robert K. Heaton, and Igor Grant Journal of Acquired Immune Deficiency Syndromes, 2020, 83, (1), 56–64. Doi : 10.1097/QAI.0000000000002211 Background : Aging and HIV have adverse effects on the central nervous system, including increased inflammation and neural injury and confer risk of neurocognitive impairment (NCI). Previous research suggests the nonacute neurocognitive effects of cannabis in the general population are adverse or null. However, in the [...]
Lire la suitePsilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers Rainer Kraehenmann, Katrin H. Preller, Milan Scheidegger, Thomas Pokorny, Oliver G. Bosch, Erich Seifritz, and Franz X. Vollenweider Biological Psychiatry, 2014. http://dx.doi.org/10.1016/j.biopsych.2014.04.010 Background : The amygdala is a key structure in serotonergic emotion-processing circuits. In healthy volunteers, acute administration of the serotonin 1A/2A/2C receptor agonist psilocybin reduces neural responses to negative stimuli and induces mood changes toward positive states. However, it is little known whether psilocybin reduces amygdala reactivity to negative stimuli and whether any change in amygdala reactivity is related to mood change. Methods : This study assessed the effects of [...]
Lire la suiteBIBLIOGRAPHIE : Cannabinoïdes, Dépression et Troubles de l’Humeur Docteur Christian SUEUR, GRECC, novembre 2019.
Lire la suiteBipolar disorder and the endocannabinoid system Shokouh Arjmand, Mina Behzadi, Kristi A. Kohlmeier, Shahrzad Mazhari, Abdolreza Sabahi and Mohammad Shabani Acta Neuropsychiatrica, 2019, 1-9. https://doi.org/10.1017/neu.2019.21 Abstract Objective : Bipolar disorder (BD) is a debilitating, lifelong neuropsychiatric illness characterised by unsteady mood states which vacillate from (hypo)mania to depression. Despite the availability of pharmaceutical agents which can be effective in ameliorating the acute affective symptoms and prevent episodic relapse, BD is inadequately treated in a subset of patients. The endocannabinoid system (ECS) is known to exert neuromodulatory effects on other neurotransmitter systems critical in governing emotions. Several studies ranging from clinical to molecular, as well as [...]
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