Translational evidence for ayahuasca as an antidepressant : what’s next ? Rafael Guimaraes dos SANTOS, José Carlos BOUSO British Journal of Psychiatry, 2019, 41, (4), 275-276. Doi : 10.1590/1516-4446-2019-4104 Depression is among the most important contributors to global disability and suicidal deaths. Available antidepressants are usually selective inhibitors of serotonin and norepinephrine uptake, which need weeks of daily intake before therapeutic effects appear, have limited efficacy for many patients, and induce significant adverse reactions after prolonged use. Therefore, recent research has focused on finding new antidepressant compounds that are fast-acting, more effective, and less toxic. The article recently published by da Silva et al. in the [...]
Lire la suiteAntidepressive and anxiolytic effects of ayahuasca : a systematic literature review of animal and human studies Rafael G. dos Santos, Flavia L. Osorio, José Alexandre S. Crippa, Jaime E.C. Hallak Revista Brasileira de Psiquiatria, 2016, 38, 65–72 doi:10.1590/1516-4446-2015-1701 ABSTRACT Objective : To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, harmine, tetrahydroharmine, and harmaline). Methods : Papers published until 3 April 2015 were retrieved from the PubMed, LILACS and SciELO databases following a comprehensive search strategy and using a predetermined set of criteria for article selection. Results : Five hundred and [...]
Lire la suiteBIBLIOGRAPHIE : Beta-Carbolines Harmine, Harmane, Harmaline, Nor-harmane, Harmol, Harmalol, Tetrahydroharmine β-Carbolines et Thérapeutique en Psychiatrie, p. 6. (cf également Bibliographie : Peganum harmala, p. 7 ci-dessous, et Bibliographie : Amanita muscaria, et Bibliographie : Ayahuasca) Dr Christian SUEUR, GRECC, décembre 2019.
Lire la suiteChemistry, pharmacology and medicinal properties of Peganum harmala L. Jinous Asgarpanah and Fereshteh Ramezanloo African journal of pharmacy and pharmacology, 2012, 6, (22), 1573-1580. Doi : 10.5897/AJPP11.876 Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also have antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects. Harmaline, [...]
Lire la suiteDistribution, Status, Pharmacological, and Traditional importance of Peganum harmala L. Nissar Ahmad Khan, Aamir Raina, Nasir Aziz Wagay, Younas Rasheed Tantray International Journal of Advance research in Science and Engineering, 2017, 6, (8), 1887-1894. www.ijarse.com ABSTRACT Peganum harmala L. Commonly known as Syrian rue, Wild rue or Harmal is native to arid and semi-arid regions of Northern African and Asian deserts that have spread to parts of the southwestern United States and Northern Mexico. It is a multipurpose medicinal plant with antimicrobial, antifungal, anti inflammatory, antidiabetic, anti cancerous, hypothermic and hallucinogenic activities. Phytochemical investigations has revealed the presences of a number of active alkaloids [...]
Lire la suiteCase report : A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract Giampietro Frison, Donata Favretto, Flavio Zancanaro, Giorgio Fazzin, Santo Davide Ferrara Forensic Science International, 2008, 179, e37–e43 doi:10.1016/j.forsciint.2008.05.003 Abstract b-Carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing b-carboline alkaloids may [...]
Lire la suiteAlkaloids Derived from Tryptophan : Harmine and Related Alkaloids T. D. Nikam, K. M. Nitnaware, and M. L. Ahire chapter 19, in K.G. Ramawat, J.M. Merillon (eds.), Natural Products, # Springer-Verlag, Berlin Heidelberg, 2013 Doi : 10.1007/978-3-642-22144-6_20 Contents 1 Synonyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 554 2 [...]
Lire la suiteThe therapeutic potential of harmine and ayahuasca in depression : Evidence from exploratory animal and human studies Flávia de Lima Osório, Ligia Ribeiro Horta de Macedo, João Paulo Machado de Sousa, Joel Porfírio Pinto, João Quevedo, José Alexandre de Souza Crippa and Jaime Eduardo C. Hallak The Ethnopharmacology of Ayahuasca, chapitre 5, 2011, 75-85 Editor : Rafael Guimarães dos Santos ISBN: 978-81-7895-526-1 Abstract The high prevalence and the socio-functional impairment associated with depressive disorders, added to the limitations of currently available treatments, justify the search for novel pharmacological strategies for the management of depression. This chapter presents the major results of animal and human studies conducted [...]
Lire la suiteSwitch to mania after ayahuasca consumption in a man with bipolar disorder : a case report Alejandro G Szmulewicz, Marina P Valerio and Jose M Smith International Journal of Bipolar Disorders, 2015, 3, (4), 1-3. DOI 10.1186/s40345-014-0020-y Abstract Background : There is an increasing use of ayahuasca for recreational purposes. Furthermore, there is a growing evidence for the antidepressant properties of its components. However, there are no reports on the effects of this substance in the psychiatric setting. Harmaline, one of the main components of ayahuasca, is a selective and reversible MAO-A inhibitor and a serotonin reuptake inhibitor. Case report : We present the case of [...]
Lire la suiteSub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution M. V. Uthaug, K. van Oorsouw, K. P. C. Kuypers, M. van Boxtel, N. J. Broers, N. L. Mason, S. W. Toennes, J. Riba, J. G. Ramaekers Psychopharmacology, 2018 https://doi.org/10.1007/s00213-018-4988-3 Abstract Rationale : Ayahuasca is a psychotropic plant tea from South America used for religious purposes by indigenous people of the Amazon. Increasing evidence indicates that ayahuasca may have therapeutic potential in the treatment of mental health disorders and can enhance mindfulness-related capacities. Most research so far has focused on acute and sub-acute effects of ayahuasca on [...]
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