Long-term effects of psychedelic drugs : A systematic review Jacob S.Adaya, Cayla M.Mitzkovitz, Emily K.Bloesch, Christopher C.Davoli, Alan K.Davis Neuroscience and Biobehavioral Reviews, 2020. Doi : 10.1016/j.neubiorev.2020.03.017 A B S T R A C T Research into the basic effects and therapeutic applications of psychedelic drugs has grown considerably in recent years. Yet, pressing questions remain regarding the substances’ lasting effects. Although individual studies have begun monitoring sustained changes, no study to-date has synthesized this information. Therefore, this systematic review aims to fill this important gap in the literature by synthesizing results from 34 contemporary experimental studies which included classic psychedelics, human subjects, and follow-up [...]
Lire la suitePsychological Explorations of the Magic Mushroom (Psilocybin) Experience, Part II : Neuropsychological Measures José Arturo Costa Escobar, M.S., Antonio Roazzi, Ph.D. Neurobiologia, 2011, 74, (3-4), 99-112. ABSTRACT Some investigations conducted with psilocybin and mushrooms of the Psilocybe genus on the human mind point to a peculiarity of these substances to promote a special state of consciousness. The present study measured the effects of dehydrated magic mushrooms on human visual processes and memory utilizing tasks in a pre- and post-test form. We observed defi cits in visual working memory and these results were consistent with other, recent psilocybin studies. However this and other visual mechanisms [...]
Lire la suitePsychiatry & the psychedelic drugs. Past, present & future James J.H. Rucker, Jonathan Iliff, David J. Nutt Neuropharmacology, 2018, 142, 200e218 https://doi.org/10.1016/j.neuropharm.2017.12.040 a b s t r a c t The classical psychedelic drugs, including psilocybin, lysergic acid diethylamide and mescaline, were used extensively in psychiatry before they were placed in Schedule I of the UN Convention on Drugs in 1967. Experimentation and clinical trials undertaken prior to legal sanction suggest that they are not helpful for those with established psychotic disorders and should be avoided in those liable to develop them. However, those with so-called ‘psychoneurotic’ disorders sometimes benefited considerably from their tendency to [...]
Lire la suiteHallucinogen Persistent Perception Disorder Induced by New Psychoactive Substituted Phenethylamines; A Review with Illustrative Case Cornel N. Stanciu and Thomas M. Penders Current Psychiatry Reviews, 2016, Vol. 12, No. 2, 1-3. DOI: 10.2174/1573400512666160216234850 Abstract : Hallucinogen Persistent Perception Disorder (HPPD) is considered an “uncommon” disorder described in association with use of hallucinogens such as LSD, mescaline and psilocybin. Despite multiple mentions of persistence of visual disturbances reported by users on online forums, clinicians may not be aware of this complication. There have been few descriptions of HPPD in association with use of new psychoactive substances (such as 2C-E). Increasing use of these designer stimulants places [...]
Lire la suitePsychedelic drugs in the treatment of anxiety, depression and addiction Tor-Morten KVAM, Lowan H. STEWART, Ole A. ANDREASSEN Tidsskrift for Den norske legeforening, 2018. Doi : 10.4045/tidsskr.17.1110 B A C K G R O U N D There is growing interest in the use of psychedelic drugs for the treatment of mental disorders. The drugs are considered safe when administered within a clinical framework. Older studies performed prior to 1970 had methodological shortcomings, but studies in recent years have shown promising results regarding the use of psychedelic drugs in unipolar depression, depression in life-threatening illness, anxiety and addiction. The aim of this literature review is [...]
Lire la suiteThe “Endless Trip” among the NPS Users : Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery and Fabrizio Schifano Frontiers in Psychiatry, 2017, Vol. 8, article 240 doi: 10.3389/fpsyt.2017.00240 Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxy-methamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases [...]
Lire la suiteHallucinogen-persisting perception disorder Leo Hermle, Melanie Simon, Martin Ruchsow and Martin Geppert Therapeutic Advances in Psychopharmacology, 2012, 2, (5), 199–205 DOI: 10.1177/2045125312451270 Abstract : A 33-year-old female patient developed a hallucinogen-persisting perception disorder (HPPD) after lysergic acid diethylamide (LSD) abuse for a year at the age of 18. Specifically, she reported after images, perception of movement in her peripheral visual fields, blurring of small patterns, halo effects, and macro- and micropsia. Previous treatment with antidepressants and risperidone failed to ameliorate these symptoms. Upon commencing drug therapy with lamotrigine, these complex visual disturbances receded almost completely. Based on its hypothesized neuroprotective and mood-stabilizing effects, the antiepileptic [...]
Lire la suiteHallucinogen persisting perception disorder after psilocybin consumption : a case study Marie-Laure Espiard, Laurent Lecardeur, Pascale Abadie, Isabelle Halbecq, Sonia Dolfuss European Psychiatry, 2005, 20, (5-6), 458-60 DOI: 10.1016/j.eurpsy.2005.04.008 Abstract The recurrence of flashbacks without acute or chronic hallucinogen consumption has been recognized in the DSM IV criteria as the hallucinogen persisting perception disorder (HPPD). Perceptual disturbances may last for 5 years or more and represent a real psychosocial distress. We reported here a case of a 18 year-old young man presenting HPPD after a mixed intoxication with psylocibin and cannabis. This report shows symptomatic recurrences persisting more than 8 months. Various differential diagnoses were [...]
Lire la suiteSurvey study of challenging experiences after ingesting psilocybin mushrooms : Acute and enduring positive and negative consequences Theresa M. Carbonaro, Matthew P. Bradstreet, Frederick S. Barrett, Katherine A. MacLean, Robert Jesse, Matthew W. Johnson and Roland R. Griffiths Journal of Psychopharmacology, 2016, 1 –11 DOI: 10.1177/0269881116662634 Abstract Acute and enduring adverse effects of psilocybin have been reported anecdotally, but have not been well characterized. For this study, 1993 individuals (mean age 30 yrs; 78% male) completed an online survey about their single most psychologically difficult or challenging experience (worst “bad trip”) after consuming psilocybin mushrooms. Thirty-nine percent rated it among the top five most challenging [...]
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