Developmental consequences of perinatal cannabis exposure : behavioral and neuroendocrine effects in adult rodents Patrizia Campolongo, Viviana Trezza, Patrizia Ratano, Maura Palmery & Vincenzo Cuomo Psychopharmacology, 2011, 214, 5–15 Doi : 10.1007/s00213-010-1892-x Abstract Rationale : Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial role in brain development, maternal exposure to cannabis derivatives might result in longlasting neurobehavioral abnormalities in the exposed offspring. It is difficult to detect these effects, and their underlying neurobiological mechanisms, in clinical cohorts, because of their intrinsic methodological and interpretative issues. Objectives : The present paper reviews relevant rodent studies examining the [...]
Lire la suiteConsumption of Ayahuasca by Children and Pregnant Women : Medical Controversies and Religious Perspectives Beatriz Caiuby Labate Journal of Psychoactive Drugs, 2011, 43, (1), 27-35. DOI: 10.1080/02791072.2011.566498 Abstract In 2010, the Brazilian Government agency responsible for drug-related issues formulated official Resolutions that categorized the consumption of ayahuasca by pregnant women and children in the Santo Daime and Uniâo do Vegetal ayahuasea-based religions as an "exercise of parental rights." Although ayahuasca groups do enjoy a relative degree of social legitimacy and formal legal recognition in Brazil, the participation of pregnant women and children nevertheless continues to provoke heated discussion. This article raises the main issues involved [...]
Lire la suiteMaternal Marijuana Use, Adverse Pregnacy Outcomes and Neonatal Morbidity, Torri D. Metz et al., 2017
Maternal Marijuana Use, Adverse Pregnancy Outcomes and Neonatal Morbidity Torri D. Metz, Ms Amanda A. Allshouse, Carol J. Rowland Hogue, Robert L. Goldenberg, Donald J. Dudley, Michael W. Varner, Deborah L. Conway, George R. Saade, and Robert M. Silver American Journal of Obstetrics and Gynecology, 2017 October ; 217, (4), 478.e1–478.e8. doi :10.1016/j.ajog.2017.05.050 Abstract Background—The NICHD Stillbirth Collaborative Research Network (SCRN) previously demonstrated an association between stillbirth and maternal marijuana use as defined by the presence of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC) in the umbilical cord homogenate. However, the relationship between marijuana use and perinatal complications in live births is uncertain. Objective—Our aim was to examine if [...]
Lire la suiteAssociation Between Marijuana Use and Adverse Obstetrical and Neonatal Outcomes CR Warshak; J Regan; B Moore; K Magner; S Kritzer; J Van Hook Journal of Perinatology, 2015, 35, 12, 991-995. PMID : 26401751 DOI : 10.1038/jp.2015.120 Abstract and Introduction Abstract Objective: To evaluate associations between marijuana exposure and adverse outcomes excluding women with polysubstance abuse and stratifying for concurrent maternal tobacco use. Study Design: We performed a retrospective cohort study evaluating various obstetrical and neonatal outcomes including: preterm delivery, pre-eclampsia, gestational diabetes, cesarean delivery, fetal growth restriction, a composite which included stillbirth or neonatal intensive care unit admission, and perinatal mortality. We stratified study groups [...]
Lire la suiteMarijuana and fertility Sara Ilnitsky MD, Stan Van Uum MD Canadian Medical Association Journal, 2019 June 10, 191, 23, E638. doi : 10.1503/cmaj.181577 CMAJ Podcasts: author interview at https://soundcloud.com/cmajpodcasts/181577-five 1 Tetrahydrocannabinol acts on the endocannabinoid system, which is ubiquitous in reproductive tissues Tetrahydrocannabinol, the active ingredient in marijuana, is a lipophilic compound with a prolonged half-life of 20–36 hours.1 Tetrahydrocannabinol activates the cannabinoid receptors, which are part of the endogenous endocannabinoid system. This system is found in the hypothalamus, pituitary and internal reproductive organs in both sexes.2,3 2 Marijuana use can decrease sperm count Smoking marijuana more than once weekly in the preceding 3 months (n = 130/1215) [...]
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