Therapeutic Use of LSD in Psychiatry : A Systematic Review of Randomized-Controlled Clinical Trials Juan José Fuentes, Francina Fonseca, Matilde Elices, Magí Farré and Marta Torrens Frontiers in Psychiatry, 2020, Vol 10, Article 943. doi : 10.3389/fpsyt.2019.00943 Lysergic acid diethylamide (LSD) was studied from the 1950s to the 1970s to evaluate behavioral and personality changes, as well as remission of psychiatric symptoms in various disorders. LSD was used in the treatment of anxiety, depression, psychosomatic diseases and addiction. However, most of the studies were not performed under contemporary standards, and it has taken several decades for a resurgence of interest in LSD research and [...]
Lire la suiteCannabinoid-Based Therapies and Brain Development : Potential Harmful Effect of Early Modulation of the Endocannabinoid System Patrícia Schonhofen, Ivi Juliana Bristot, José Alexandre Crippa, Jaime Eduardo Cecílio Hallak, Antônio Waldo Zuardi, Richard B. Parsons, Fábio Klamt CNS Drugs, 2018, 32, (Suppl 1), 1-16. Springer Nature Switzerland, Doi : 10.1007/s40263-018-0550-4 Abstract The endocannabinoid retrograde signaling pathway is widely expressed in the central nervous system, where it plays major roles in regulating synaptic plasticity (excitatory and inhibitory) through long-term potentiation and long-term depression. The endocannabinoid system (ECS) components—cannabinoid receptors, endocannabinoids and synthesis/degradation enzymes—are expressed and are functional from early developmental stages and throughout adolescent cortical development, regulating progenitor [...]
Lire la suiteThe Bastiaans Method of Drug-Assisted Therapy A preliminary follow-up study with former clients Hans Ossebaard & Nicole Maalste Bulletin of the Multidisciplinary Association for Psychedelic Studies, MAPS : 1999, Vol 9, N° 2, pp. 3-9 This study was made possible in part by a grant to MAPS from the Promind Foundation The present pilot study is a preliminary investigation among former clients who participated in therapy supervised by Bastiaans and his collaborators (see MAPS Bulletin, VIII (2), p. 3; 1998) and conducted with the help of hallucinogenic drugs. This follow-up study aims to systematically establish the subjective judgements of clients, to work out a profile that [...]
Lire la suiteNeurotoxicity and LSD treatment : a follow-up study of 151 patients in Denmark Jens Knud Larsen University Hospital of Aarhus, Risskov, Denmark History of Psychiatry, 2016, Vol. 27, (2), 172–189 DOI: 10.1177/0957154X16629902 Abstract LSD was introduced in psychiatry in the 1950s. Between 1960 and 1973, nearly 400 patients were treated with LSD in Denmark. By 1964, one homicide, two suicides and four suicide attempts had been reported. In 1986 the Danish LSD Damages Law was passed after complaints by only one patient. According to the Law, all 154 applicants received financial compensation for LSD-inflicted harm. The Danish State Archives has preserved the case material of 151 [...]
Lire la suiteLong-term effects of ayahuasca in patients with recurrent depression : a 5-year qualitative follow-up Rafael G. dos Santos, Rafael Faria Sanches, Flávia de Lima Osório, Jaime E.C. Hallak Archive of Clinical Psychiatry, 2018, 45, 1, 22-4 DOI: 10.1590/0101-60830000000149 Abstract Background : Ayahuasca is a botanical hallucinogenic preparation traditionally used by indigenous populations of Northwestern Amazonian countries for ritual and therapeutic purposes. It is rich in β-carboline alkaloids and N,N-dimethyltryptamine (DMT). Preclinical, observational, and experimental studies suggest that ayahuasca and its alkaloids have anxiolytic and antidepressive effects. We recently reported in an open-label trial that ayahuasca administration was associated with significant decreases in depression symptoms for [...]
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