Neuroanatomical substrates involved in cannabinoid modulation of defensive responses F.A. Moreira, D.C. Aguiar, L.B. Resstel, S.F. Lisboa, A.C. Campos, F.V. Gomes and F.S. Guimaraes Journal of Psychopharmacology, 2012, 26, (1), 40–55 DOI: 10.1177/0269881111400651   Abstract Administration of Cannabis sativa derivatives causes anxiolytic or anxiogenic effects in humans and laboratory animals, depending on the specific compound and dosage used. In agreement with these findings, several studies in the last decade have indicated that the endocannabinoid system modulates neuronal activity in areas involved in defensive responses. The mechanisms of these effects, however, are still not clear. The present review summarizes recent data suggesting that they involve modulation of [...]