Efficacy and safety of psilocybin-assisted treatment for major depressive disorder : Prospective 12-month follow-up Natalie Gukasyan, Alan K Davis, Frederick S Barrett, Mary P Cosimano, Nathan D Sepeda, Matthew W Johnson and Roland R Griffiths Journal of Psychopharmacology, 2022, Vol. 36(2) 151–158. Doi : 10.1177/02698811211073759 Abstract Background : Preliminary data suggest that psilocybin-assisted treatment produces substantial and rapid antidepressant effects in patients with major depressive disorder (MDD), but little is known about long-term outcomes. Aims : This study sought to examine the efficacy and safety of psilocybin through 12 months in participants with moderate to severe MDD who received psilocybin. Methods : This randomized, waiting-list controlled study [...]
Lire la suiteLSD, madness and healing : Mystical experiences as possible link between psychosis model and therapy model Isabel Wießner, Marcelo Falchi, Fernanda Palhano-Fontes, Amanda Feilding, Sidarta Ribeiro and Luís Fernando Tófoli Psychological Medicine, 2021, 1-15. Doi : 10.1017/S0033291721002531 Abstract Background : For a century, psychedelics have been investigated as models of psychosis for demonstrating phenomenological similarities with psychotic experiences and as therapeutic models for treating depression, anxiety, and substance use disorders. This study sought to explore this paradoxical relationship connecting key parameters of the psychotic experience, psychotherapy, and psychedelic experience. Methods : In a randomized, double-blind, placebo-controlled, crossover design, 24 healthy volunteers received 50 μg D-lysergic acid diethylamide (LSD) or inactive placebo. [...]
Lire la suitePost-acute psychological effects of classical serotonergic psychedelics: a systematic review and meta-analysis Simon B. Goldberg, Benjamin Shechet, Christopher R. Nicholas, Chi Wing Ng, Geetanjali Deole, Zhuofan Chen and Charles L. Raison Psychological Medicine, 2020, 1–12. doi : 10.1017/S003329172000389X Abstract Background. Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate [...]
Lire la suiteMystical Experiences in Retrospective Reports of First Times Using a Psychedelic in Finland Samuli Kangaslampi, PhD , Aino Hausen, BA, and Tarina Rauteenmaa, BA JOURNAL OF PSYCHOACTIVE DRUGS, 2020, 1-10 Doi : 10.1080/02791072.2020.1767321 ABSTRACT Despite their acutely inebriating and sometimes unpleasant effects, some people report positive changes in life satisfaction, well-being, or mental health after taking psychedelic drugs. One explanation may be the ability of psychedelics to trigger mystical-type experiences. We examined the validity, reliability, and factor structure of a novel Finnish translation of the Revised Mystical Experiences Questionnaire (MEQ30) among 288 people retrospectively reporting on their first time using a psychedelic. We found evidence [...]
Lire la suiteBIBLIOGRAPHIE : Substances psychédéliques : anthropologie, sociologie, spiritualité, chamanisme, culture… Docteur Christian Sueur, GRECC, mai 2020 Substances psychédéliques, anthropologie, sociologie, culture… : pp 1 - 6 Substances psychédéliques et Chamanisme : pp 7 - 10 Psychédéliques et “spiritualité” : religion, mysticisme, enthéogènes : pp 11 - 23
Lire la suiteA Comparative Literature Survey of Psilocybin and LSD-25 Metabolism Ian Joyce Capstone Project CHM 400 H Cal Poly Pomona, Winter 2017 | 1 - &ç Psilocybin and lysergic acid diethylamide (LSD-25) are two of the most popular and well known psychedelic drugs. Although both of the compounds are currently illegal in the United States, a renewed interest has begun in recent years to examine and analyze these drugs for therapeutic use. This review analyzes the current research pertaining to the metabolism, biochemical pathways, receptor activity, biological signaling, physiological effects and the behavioral effects associated with both of these compounds. For psychedelic compounds to [...]
Lire la suiteTherapeutic Potential of Psychedelic Drugs Justin Briglio University of Maine, 2015, 31 p. Table of Contents Introduction......................................................................................................................................3 History of Psychedelic Research.....................................................................................................6 Recent Research...............................................................................................................................8 Neurobiology of Psychedelics.........................................................................................................9 Therapeutic Potential of Psilocybin...............................................................................................12 Therapeutic Potential of LSD........................................................................................................15 Therapeutic Potential of Ayahuasca..............................................................................................19 Therapeutic Potential of Ibogaine..................................................................................................22 Conclusion.....................................................................................................................................26 References......................................................................................................................................28 A psychedelic compound is a psychoactive drug whose main action is to alter perception and cognition. Psychedelics are distinctive from other psychoactive drugs in that they alter the mind, whereas opiates or stimulants alter the mood (Meyer & Quenzer, 2013). Psychedelics affect nature of consciousness itself and access otherwise unknown states of consciousness, as opposed to affecting the degree or extent of one's consciousness and inducing proverbial moods such as [...]
Lire la suiteEntheogens Katie Givens Kime Institute of Practical Theology, University of Bern, Bern, Switzerland in D. A. Leeming (ed.), "Encyclopedia of Psychology and Religion", # Springer-Verlag GmbH Germany, part of Springer Nature 2018 Doi : 10.1007/978-3-642-27771-9_200181-1 Entheogen is a term coined in the late 1970s by a group of botanists and scholars which refers to any psychoactive agent which allows for “generating the divine within” (Ruck et al. 1979). Entheogens are psychedelic substances which, in adequate dosage under supportive conditions, are known to facilitate visionary, mystical, and/or spiritual experiences. Such substances include psilocybin, peyote, LSD (lysergic acid diethylamide), ibogaine, and ayahuasca. Typically of plant origin, entheogens are [...]
Lire la suiteIntensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study Joseph Barsuglia, Alan K. Davis, Robert Palmer, Rafael Lancelotta, Austin-Marley Windham-Herman, Kristel Peterson, Martin Polanco, Robert Grant and Roland R. Griffiths Frontiers in Psychology, 2018, Vol 9, Article doi : 10.3389/fpsyg.2018.02459 5-MeO-DMT is a psychoactive substance found in high concentrations in the bufotoxin of the Colorado River Toad (Bufo alvarius). Emerging evidence suggests that vaporized 5-MeO-DMT may occasion mystical experiences of comparable intensity to those occasioned by more widely studied psychedelics such as psilocybin, but no empirical study has tested this hypothesis. Data was obtained from 20 individuals (Mage = [...]
Lire la suiteClassic Hallucinogens and Mystical Experiences : Phenomenology and Neural Correlates Frederick S. Barrett, Roland R. Griffiths Current Topics in Behavioral Neurosciences, 2018, 36, 393–430. doi : 10.1007/7854_2017_474 Abstract This chapter begins with a brief review of descriptions and definitions of mystical-type experiences and the historical connection between classic hallucinogens and mystical experiences. The chapter then explores the empirical literature on experiences with classic hallucinogens in which claims about mystical or religious experiences have been made. A psychometrically validated questionnaire is described for the reliable measurement of mystical-type experiences occasioned by classic hallucinogens. Controlled laboratory studies show that under double-blind conditions that provide significant controls for [...]
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