Cannabidiol as an add-on therapy to overcome the slow-onset and, possibly, resistance to antidepressant treatment : involvement of NAPE-PLD in the medial prefrontal cortex. Franciele F. Scarante, Vinícius D. Lopes, Eduardo J. Fusse, Maria A. Vicente, Melissa R. Araújo, Davi S. Scomparin, Rafael P. Aguiar, Francisco S. Guimarães, Viviani Nardinid, Carlos Arterio Sorgid, Lucia H. Faccioli, RhD, PhDd, Jaime E. C. Hallak, MD, PhDe,f; Samia Joca, Kenneth Mackie, Antonio Waldo Zuardi, José Alexandre S. Crippa, Alline C. Campos. bioRxiv preprint, April 26, 2021. doi : 10.1101/2021.04.23.441143 Highlights ● In mice, cannabidiol (CBD), but not escitalopram, induced a fast-onset anti-stress action. ● Combinations of sub-effective doses [...]
Lire la suiteLong-Term Stress and Concomitant Marijuana Smoke Exposure Affect Physiology, Behavior and Adult Hippocampal Neurogenesis Kitti Rusznák, Kata Csekö, Zsófia Varga, Dávid Csabai, Ágnes Bóna, Mátyás Mayer, Zsolt Kozma, Zsuzsanna Helyes and Boldizsár Czéh Frontiers in Pharmacology, 2018, 9, 786 doi: 10.3389/fphar.2018.00786. eCollection 2018 www.frontiersin.org Abstract Marijuana is a widely used recreational drug with increasing legalization worldwide for medical purposes. Most experimental studies use either synthetic or plant-derived cannabinoids to investigate the effect of cannabinoids on anxiety and cognitive functions. The aim of this study was to mimic real life situations where young people smoke cannabis regularly to relax from everyday stress. Therefore, we exposed young adult [...]
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