Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids E. Appiah-Kusi, R. Wilson, M.Colizzi, E. Foglia, Sagnik Bhattacharyya, et al. Psychological Medicine, 2019. DOI: https://doi.org/10.1017/S0033291719001946 Published online by Cambridge University Press: 19 August 2019 Abstract BackgroundEvidence has been accumulating regarding alterations in components of the endocannabinoid system in patients with psychosis. Of all the putative risk factors associated with psychosis, being at clinical high-risk for psychosis (CHR) has the strongest association with the onset of psychosis, and exposure to childhood trauma has been linked to an increased risk of development of psychotic disorder. We aimed to investigate whether being at-risk for [...]
Lire la suiteWhy Psychiatry Needs 3,4 Methylenedioxymeth-amphetamine : A Child Psychiatrist’s Perspective Ben SESSA Neurotherapeutics, 2017, 14, (3), 741-749. doi:10.1007/s13311-017-0531-1 Abstract Since the late 1980s the psychoactive drug 3,4-methylenedioxymethamphetamine (MDMA) has had a well-known history as the recreationally used drug ecstasy. What is less well known by the public is that MDMA started its life as a therapeutic agent and that in recent years an increasing amount of clinical research has been undertaken to revisit the drug’s medical potential. MDMA has unique pharmacological properties that translate well to its proposed agent to assist trauma-focused psychotherapy. Psychological trauma—especially that which arises early in life from child abuse—underpins many [...]
Lire la suiteReview of Sacred Knowledge : Psychedelics and Religious Experience William A. Richards New York, NY: Columbia University Press, 2016. 269 pp. ISBN 978-0-231-17406-0 $29.95 Reviewed by Michael J. Winkelman http://dx.doi.org/10.1037/a0040299 Abstract Reviews the book, Sacred knowledge: Psychedelics and religious experiences, by William A. Richards. Richards’s career of clinical research with psychedelics and professional formation in theology, comparative religion and the psychology of religion bring integrative perspectives to understanding psychedelic experiences. Clinical accounts, scientific research and his personal experiences with psychedelics enable Richards to address issues of core importance in religious studies, medicine and society in general. Clinical studies with psychedelics provide findings that contribute to assessment of [...]
Lire la suiteThe link between childhood trauma and dissociation in frequent users of classic psychedelics and dissociatives Sascha B. Thal, Judith K. Daniels & Henrik Jungaberle Journal of Substance Use, may 2019 https://doi.org/10.1080/14659891.2019.1614234 ABSTRACT Background : Childhood trauma severity is associated with the level of subsequent substance use as well as with the self-reported severity of dissociation. Classic psychedelics and dissociatives target neurotransmitter systems thought to be involved in the onset of dissociative symptoms and may evoke severe and long-lasting symptoms of depersonalization in some users. However, it is currently unclear whether drug use puts people with a history of childhood trauma at higher risk of developing [...]
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