Nabiximols combined with motivational enhancement/cognitive behavioral therapy for the treatment of cannabis dependence : A pilot randomized clinical trial Jose M. Trigo, Alexandra Soliman, Lena C. Quilty, Benedikt Fischer, JuÈrgen Rehm, Peter Selby, Allan J. Barnes11¤a, Marilyn A. Huestis, Tony P. George, David L. Streiner, Gregory Staios, Bernard Le Foll PLoS ONE, 2018, 13, (1), e0190768. https://doi.org/10.1371/journal.pone.0190768 Abstract Background The current lack of pharmacological treatments for cannabis use disorder (CUD) warrants novel approaches and further investigation of promising pharmacotherapy. We previously showed that nabiximols (27 mg/ml Δ9-tetrahydrocannabinol (THC)/ 25 mg/ml cannabidiol (CBD), Sativex®) can decrease cannabis withdrawal symptoms. Here, we assessed in a pilot study the [...]
Lire la suiteReefer Madness : A Case of Cannabis-Induced Psychosis Matthew C. Ballenberger, Robert D. Glatter, Daniel P. Klein, Steven Mandel, Medscape Psychiatry, August 15, 2019 Clinical Presentation A 32-year-old woman with a history of iron-deficiency anemia was brought in by ambulance because of altered mental status. The patient's sister and boyfriend reported that 1 day before presentation, the patient had ingested a marijuana edible and a few hours later developed fatigue and nausea, followed by at least 15 episodes of nonbloody, nonbilious, projectile vomiting throughout the night. In the morning, she became very pale, her lips turned blue, and she became stiff, losing consciousness for [...]
Lire la suiteHallucinogen persisting perception disorder after psilocybin consumption : a case study Marie-Laure Espiard, Laurent Lecardeur, Pascale Abadie, Isabelle Halbecq, Sonia Dolfuss European Psychiatry, 2005, 20, (5-6), 458-60 DOI: 10.1016/j.eurpsy.2005.04.008 Abstract The recurrence of flashbacks without acute or chronic hallucinogen consumption has been recognized in the DSM IV criteria as the hallucinogen persisting perception disorder (HPPD). Perceptual disturbances may last for 5 years or more and represent a real psychosocial distress. We reported here a case of a 18 year-old young man presenting HPPD after a mixed intoxication with psylocibin and cannabis. This report shows symptomatic recurrences persisting more than 8 months. Various differential diagnoses were [...]
Lire la suiteBeta-caryophyllene is a dietary cannabinoid Jürg Gertsch, Marco Leonti, Stephan Raduner, Ildiko Racz, Jian-Zhong Chen, Xiang-Qun Xie, Karl-Heinz Altmann, Meliha Karsak and Andreas Zimmer PNAS (Proceedings of the National Academy of Sciences of the USA), 2008, 105, (26), 9099-9104. Doi : 10.1073/pnas.0803601105 Abstract The psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived endocannabinoids are nonselective natural ligands for cannabinoid receptor type 1 (CB1) and CB2 receptors. Although the CB1 receptor is responsible for the psychomodulatory effects, activation of the CB2 receptor is a potential therapeutic strategy for the treatment of inflammation, pain, atherosclerosis, and osteoporosis. Here, we report that the widespread plant volatile [...]
Lire la suiteMaternal Marijuana Use, Adverse Pregnacy Outcomes and Neonatal Morbidity, Torri D. Metz et al., 2017
Maternal Marijuana Use, Adverse Pregnancy Outcomes and Neonatal Morbidity Torri D. Metz, Ms Amanda A. Allshouse, Carol J. Rowland Hogue, Robert L. Goldenberg, Donald J. Dudley, Michael W. Varner, Deborah L. Conway, George R. Saade, and Robert M. Silver American Journal of Obstetrics and Gynecology, 2017 October ; 217, (4), 478.e1–478.e8. doi :10.1016/j.ajog.2017.05.050 Abstract Background—The NICHD Stillbirth Collaborative Research Network (SCRN) previously demonstrated an association between stillbirth and maternal marijuana use as defined by the presence of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC) in the umbilical cord homogenate. However, the relationship between marijuana use and perinatal complications in live births is uncertain. Objective—Our aim was to examine if [...]
Lire la suiteAn Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors Paula Morales and Patricia H. Reggio Cannabis and Cannabinoid Research, 2017, Volume 2.1, 265-273 DOI: 10.1089/can.2017.0036 Abstract The endocannabinoid system (ECS) has been shown to be of great importance in the regulation of numerous physiological and pathological processes. To date, two Class A G-protein-coupled receptors (GPCRs) have been discovered and validated as the main therapeutic targets of this system: the cannabinoid receptor type 1 (CB1), which is the most abundant neuromodulatory receptor in the brain, and the cannabinoid receptor type 2 (CB2), predominantly found in the immune system among other organs and tissues. Endogenous cannabinoid receptor [...]
Lire la suitePrice elasticity of illegal versus legal cannabis: a behavioral economic substitutability analysis Michael Amlung, Derek D. Reed, Vanessa Morris, Elizabeth R. Aston, Jane Metrik & James MacKillop Addiction, 2018, 114, 112–118 doi:10.1111/add.14437 ABSTRACT Background and Aims : The evolving legal status of cannabis world-wide necessitates evidence-based regulatory policies to minimize risks associated with cannabis misuse. A prominent concern is the impact legalization may have on the illegal cannabis market, including whether illegal cannabis will serve as a substitute for legal cannabis. Empirical data on this issue are virtually non-existent. This study used behavioral economics to investigate substitutability of legal and illegal cannabis in legalized catchment areas [...]
Lire la suiteAlessandro Stella Directeur de recherche CNRS Equipe(s) : GEI Laboratoire(s) de rattachement : CRH Coordonnées professionnelles EHESS-CRH GEI (Bureau A 04-11) 54, boulevard Raspail 75006 Paris alessandro.stella (a) wanadoo.fr 01 49 54 24 42 http://gei.ehess.fr/index.php?942 Diplômes 1987 : Diplôme de l’EHESS, sous la direction de Mme Christiane Klapisch-Zuber : « Sur les traces laissées par les Ciompi en révolte : les hommes, les lieux, le travail », rapporteur M. Jacques Le Goff. Prix du meilleur diplôme de l’EHESS. 1992 : Doctorat de l’EHESS, sous la direction de Mme Christiane Klapisch-Zuber : « Un tableau florentin du Trecento. Fiscalité, topographie et société dans la deuxième moitié du XIVe siècle ». Mention : « Très honorable ». 2007 : Habilitation à Diriger des Recherches, Université [...]
Lire la suiteStates Want Pot to Grow Greener as Legal Cannabis Expands Bloomberg Environment, Posted July 19, 2019, 12:01 PM https://news.bloombergenvironment.com/environment-and-energy/states-want-pot-to-grow-greener-as-legal-cannabis-expands Sustainability considered as part of legalization Regulations address pesticides, air quality As more states legalize recreational and medical marijuana, they’re confronting the reality that cannabis production involves using huge amounts of pesticides, energy, and water, while generating tons of plant and packaging waste. The result is a patchwork of air, water, pesticide, and waste regulations for the industry across dozens of states, even as the substance remains illegal at the federal level. States like Michigan, where the Marijuana Regulatory Agency will begin accepting business licenses in [...]
Lire la suiteAssociations between Adolescent Cannabis Use and Neuropsychological Decline : A Longitudinal Co-Twin Control Study Madeline H. Meier, Avshalom Caspi, Andrea Danese, Helen L. Fisher, Renate Houts, Louise Arseneault, & Terrie E. Moffitt Addiction. 2018, 113, (2), 257-265. doi: 10.1111/add.13946. Abstract Aims : This study tested whether adolescents who used cannabis or met criteria for cannabis dependence showed neuropsychological impairment prior to cannabis initiation and neuropsychological decline from before to after cannabis initiation. Design : A longitudinal co-twin control study. Setting and Participants : Participants were 1,989 twins from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative birth cohort of twins born in England and Wales [...]
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