Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability Ziva D. Cooper, Gillinder Bedi, Divya Ramesh, Rebecca Balter, Sandra D. Comer and Margaret Haney Neuropsychopharmacology, 2018, 0, 1–10 Doi : 10.1038/s41386-018-0011-2   Cannabinoids combined with opioids produce synergistic antinociceptive effects, decreasing the lowest effective antinociceptive opioid dose (i.e., opioid-sparing effects) in laboratory animals. Although pain patients report greater analgesia when cannabis is used with opioids, no placebo-controlled studies have assessed the direct effects of opioids combined with cannabis in humans or the impact of the combination on abuse liability. This double-blind, placebo-controlled, within-subject study determined if cannabis enhances the analgesic effects [...]