Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression Beth M. Wiese, Erika Liktor-Busa, Aidan Levine, Sarah A. Couture, Spyros P. Nikas, Lipin Ji, Yingpeng Liu, Kenneth Mackie, Alexandros Makriyannis, Tally M. Largent-Milnes and Todd W. Vanderah Cannabis and Cannabinoid Research, 2021, Volume 6, Number 5, 401-412. Doi : 10.1089/can.2020.0076 Abstract Introduction : An escalating number of fatalities resulting from accidental opioid overdoses typically attributed to respiratory depression continue to define the opioid epidemic. Opioid respiratory depression results from a decrease in reflexive inspiration within the preBo¨ tzinger complex in the brainstem. Objective : Cannabinoid receptor agonism is reported to enhance opioid analgesia, yet whether cannabinoids enhance [...]
Lire la suiteA spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C. Pimenta, Igor Dimitri Gama Duarte and Maria Elena de Lima Journal of Venomous Animals and Toxins including Tropical Diseases, 2016, 22, 34, Doi : 10.1186/s40409-016-0091-6 Abstract Background : Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in its action [...]
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