Human Pharmacokinetics and Adverse Effects of Pulmonary and Intravenous THC-CBD Formulations Pascale Meyer, Manuela Langos, Rudolf Brenneisen Medical Cannabis and Cannabinoids, 2018, 1, 36–43 Preclinical Science and Clinical Studies – Research Article DOI: 10.1159/000489034 Abstract Background : Due to variable absorption and extensive firstpass metabolism, the bioavailability of oral delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is low, and, therefore, alternative application forms are necessary. Methods : In an open-label, 2-period phase-1 study on 11 healthy volunteers, a combination of THC and CBD was compared by pulmonary (inh) and intravenous (iv) application. The liquid aerosol was produced by an in vitro validated pressurized metered-dose inhaler (pMDI) device, releasing 41–44% [...]
Lire la suiteCannabinoid Hyperemesis Joseph V. Pergolizzi Jr., Jo Ann LeQuang, John F. Bisney Medical Cannabis and Cannabinoids, 2018, 1, 73–95 DOI: 10.1159/000494992 https://www.karger.com/Article/FullText/494992 Abstract : Cannabinoid hyperemesis syndrome (CHS) is a paradoxical condition in which a long-term cannabis user suffers an episode of intractable vomiting that may last days separated by longer asymptomatic periods of weeks or months. Cannabinoids are often utilized for their antiemetic properties, so CHS can be a puzzling condition, and the diagnosis of CHS may be disputed by patients. Unlike other cyclic vomiting syndromes, CHS can be relieved by hot showers or topical capsaicin. Abstinence from cannabinoids causes CHS to resolve, sometimes in [...]
Lire la suiteCannabis legalization in Canada: how might ‘strict’ regulation impact youth? Tara Marie Watson & Patricia G. Erickson DRUGS: EDUCATION, PREVENTION AND POLICY, 2018 https://doi.org/10.1080/09687637.2018.1482258 EDITORIAL Cannabis legalization in Canada: how might ‘strict’ regulation impact youth? Canada is on course to become, in October 2018, the second country in the world, after Uruguay, to federally legalize cannabis for recreational use. Prime Minister Justin Trudeau’s Liberal government has set out to achieve several objectives with this major drug policy reform, including ‘[to] Protect young Canadians by keeping marijuana out of the hands of children and youth’ (Government of Canada, 2016). While protecting the health and safety of [...]
Lire la suiteSex Differences in Cannabis Use and Effects: A Cross-Sectional Survey of Cannabis Users Carrie Cuttler, Laurie K. Mischley, and Michelle Sexton Cannabis and Cannabinoid Research, 2016, 1, 1, 166-175 DOI : 10.1089/can.2016.0010 Abstract Introduction : Despite known sex differences in the endocannabinoid system of animals, little attention has been paid to sex differences in human's cannabis use patterns and effects. The purpose of the present study was to examine sex differences in cannabis use patterns and effects in a large sample of recreational and medical cannabis users. Methods : A large sample (n=2374) of cannabis users completed an anonymous, online survey that assessed their cannabis use [...]
Lire la suiteAssociation of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood - A Systematic Review and Meta-analysis Gabriella Gobbi, Tobias Atkin, Tomasz Zytynski, Shouao Wang, Sorayya Askari, Jill Boruff, Mark Ware, Naomi Marmorstein, Andrea Cipriani, Nandini Dendukuri, Nancy Mayo JAMA Psychiatry, 2019, 76, 4, 426-434. doi:10.1001/jamapsychiatry.2018.4500 Published online February 13, 2019. Corrected on March 13, 2019. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2723657?guestAccessKey=c2ffca43-46c1-4563-8949-c1625bfbdefa&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetwork&utm_content=weekly_highlights&utm_term=051919 IMPORTANCE : Cannabis is the most commonly used drug of abuse by adolescents in the world. While the impact of adolescent cannabis use on the development of psychosis has been investigated in depth, little is known about the impact of cannabis use on mood [...]
Lire la suiteChanges in cannabis potency and first-time admissions to drug treatment: a 16-year study in the Netherlands Tom P. Freeman, Peggy van der Pol, Wil Kuijpers, Jeroen Wisselink, Ravi K. Das, Sander Rigter, Margriet van Laar, Paul Griffiths, Wendy Swift, Raymond Niesink and Michael T. Lynskey Psychological Medicine, 2018 https://doi.org/10.1017/S0033291717003877 Abstract Background : The number of people entering specialist drug treatment for cannabis problems has increased considerably in recent years. The reasons for this are unclear, but rising cannabis potency could be a contributing factor. Methods : Cannabis potency data were obtained from an ongoing monitoring programme in the Netherlands. We analysed concentrations of δ-9-tetrahydrocannabinol (THC) from [...]
Lire la suiteSupplément Technique : Les Nouveaux Produits de Synthèse Essayer la régulation des usages…. L’arrivée des produits que l’on appelle les « Research Chemicals » ou « legal high » n’est pas un hasard. Elle correspond à une évolution de la société addictogène qui se décline sur plusieurs éléments : - Une nouvelle génération s’est emparée de l’outil Internet et passe énormément de temps « online », dans le monde de la « toile » où continue de s’exprimer une quête de plaisir. Cette nouvelle génération d'usagers partage ses expériences d'usage de NPS à travers des forums internet d'auto-support et acquiert une réelle expertise. - [...]
Lire la suiteDossier : le Cannabis et la vision Le Cannabiste.com https://lecannabiste.com/dossier-le-cannabis-et-la-vision/ 4 juillet 2018 jean-pierre Si vous posez la question à des utilisateurs réguliers de Cannabis, la plupart vous répondra que l’usage de cette plante constitue pour eux une source de confort et de bien-être. Pour autant nous savons tous que l’usage du Cannabis n’est pas sans incidence sur le corps humain. Les implications du Cannabis sur l’organisme sont nombreuses et parfois plus complexes qu’il n’y paraît. Dans cet article nous nous allons nous intéresser de plus près à l’état des connaissances et aux événements marquants qui ont émaillé la recherche dans le domaine si particulier, [...]
Lire la suiteEtude : la consommation de cannabis peut poser problème en cas d’anesthésie Newsweed.fr, Etudes 16 avril 2019 Camille Lezaun https://www.newsweed.fr/etude-cannabis-anesthesie/ Une étude récente (https://www.grecc.org/publications/essais-cliniques/effects-of-cannabis-use-on-sedation-requirements-for-endoscopic-procedures-mark-a-twardowski-et-al-2019/) publiée dans le journal de l’Association Américaine d’Ostéopathie a trouvé que la consommation de cannabis pouvait modifier la tolérance de certains patients aux sédatifs. En effet, selon cette étude, les consommateurs de cannabis ont besoin de doses en moyenne deux fois plus importantes que les non-consommateurs. Cette découverte pourrait avoir des répercussions importantes sur la pratique médicale. L’étude L’étude s’est tenue au Colorado qui a légalisé le cannabis récréatif en 2012. Les chercheurs ont étudié les fichiers de plusieurs patients ayant [...]
Lire la suiteEffects of Cannabis Use on Sedation Requirements for Endoscopic Procedures Mark A. Twardowski, Margaret M. Link, Nicole M. Twardowski The Journal of the American Osteopathic Association, 2019 (Published online April 15, 2019). doi:10.7556/jaoa.2019.052 Context : Cannabis (or marijuana) became legal for recreational use in Colorado in 2012, and this legislation change has created both challenges and opportunities in medicine. More patients are using cannabis, and more patients are now willing to admit cannabis use than in the past, which increases the likelihood that they will be forthcoming about use during medical questioning. Cannabis use may have implications during medical care, including procedural sedation. Objective : [...]
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