Cannabinoid Delivery Systems for Pain and Inflammation Treatment Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Enrica Pessione, Daniela Gastaldi and Franco Dosio Molecules, 2018, 23, 2478 doi:10.3390/molecules23102478 www.mdpi.com/journal/molecules Abstract : There is a growing body of evidence to suggest that cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions. The transformation of cannabinoids from herbal preparations into highly regulated prescription drugs is therefore progressing rapidly. The development of such drugs requires well-controlled clinical trials to be carried out in order to objectively establish therapeutic efficacy, dose ranges and [...]
Lire la suiteChanges in cannabis potency and first-time admissions to drug treatment: a 16-year study in the Netherlands Tom P. Freeman, Peggy van der Pol, Wil Kuijpers, Jeroen Wisselink, Ravi K. Das, Sander Rigter, Margriet van Laar, Paul Griffiths, Wendy Swift, Raymond Niesink and Michael T. Lynskey Psychological Medicine, 2018 https://doi.org/10.1017/S0033291717003877 Abstract Background : The number of people entering specialist drug treatment for cannabis problems has increased considerably in recent years. The reasons for this are unclear, but rising cannabis potency could be a contributing factor. Methods : Cannabis potency data were obtained from an ongoing monitoring programme in the Netherlands. We analysed concentrations of δ-9-tetrahydrocannabinol (THC) from [...]
Lire la suiteThe Cannabis sativa Versus Cannabis indica Debate : An Interview with Ethan Russo Daniele Piomelli and Ethan B. Russo Cannabis and Cannabinoid Research, 2016, 1, 1, 44-46 https://doi.org/10.1089/can.2015.29003.ebr Dr. Ethan Russo, MD, is a board-certified neurologist, psychopharmacology researcher, and Medical Director of PHYTECS, a biotechnology company researching and developing innovative approaches targeting the human endocannabinoid system. Previously, from 2003 to 2014, he served as Senior Medical Advisor and study physician to GW Pharmaceuticals for three Phase III clinical trials of Sativex for alleviation of cancer pain unresponsive to optimized opioid treatment and studies of Epidiolex for intractable epilepsy. He has held faculty appointments in [...]
Lire la suiteTerpenes HAPA Medical web site, 2019 https://www.hapa-medical.com/medical-cannabis/phyto-cannabinoids/terpene Terpenes form the main component of a plant’s essential oils and account for its characteristic smell and taste. Terpenes also appear to be important for the precise regulation of cannabis pharmacology by e.g. modulating GABAergic neurotransmission. Preliminary results indicate that cannabis terpenes could play a significantly greater therapeutic role as initially presumed, however more research is still required. Here is an overview of the most commonly-occurring terpenes in cannabis and their postulated medicinal effects. Terpenes form the main component of a plant’s essential oils, and over 8,000 different terpenes have been identified to date. They account for [...]
Lire la suiteCBG & others HAPA Medical web site , 2019 https://www.hapa-medical.com/medical-cannabis/phyto-cannabinoids/cbg-others In addition to the most well-known phytocannabinoids THC and CBD, cannabis contains more than 100 other phytocannabinoids which could have therapeutic properties. In this article you will find an overview of the most well-known and commonly-occurring ones: cannabigerol (CBG), beta-caryophyllene (BCP), cannabidivarin (CBDV), cannabinol (CBN), cannabichromene (CBC) and tetrahydrocannabivarin (THCV). These active compounds (and terpenes) are absent in cannabinoid isolates, however in full-spectrum extracts they are present in varying proportions of course, which means that a possible entourage effect of the substances can be exploited. In addition to the most well-known phytocannabinoids THC and [...]
Lire la suiteCannabis Robert Hämmig, Ulrich W. Preuss und Michael Soyka January 2019 DOI: 10.1016/B978-3-437-23021-9.00009-6 Kernaussagen ● Die Cannabispflanze, welche die Menschheit seit Jahrtausenden begleitet, wird vi elfältig genutzt: ○ als Lieferant für Fasern zur Herstellung von Tüchern, Schnüren, Seilen und Papier, ○ als Nahrungsmittel (Samenkörner und Öl), ○ als Medizin für Mensch und Tier sowie als Genussmittel. ● Im 19. Jh. hielt Cannabis Einzug in die moderne westliche Medizin und wurde auch als „Freizeitdroge“ genutzt. Aus dieser Zeit stammen detaillierte phänomenologische Bes chreibungen der Effekte. Noch blieb aber der Wirkmechanismus völlig unklar. ● Die erste Hälfte des 20. Jh. ist das „dunkle Zeitalter“ des Cannabis, in dem das Fors chungsinteresse erlahmte. [...]
Lire la suiteLes Phyto-cannabinoïdes Non-psychotropes* : Les nouvelles Opportunités d'une plante ancienne.(*NdT : non-stupéfiants) Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo and Raphael Mechoulam Trends in Pharmacological Sciences - CELL Press, 2009, 30, 10, 515-27. doi: 10.1016/j.tips.2009.07.006. Le Δ9-tetrahydrocannabinol (Δ9THC) se lie aux récepteurs endocannabinoïdes (CB1 et CB2) qui sont activés par les cannabinoïdes endogènes (endocannabinoïdes) et qui sont impliqués dans une large gamme de processus physiopathologiques (exemple: modulation de la libération de neurotransmetteurs, régulation de la perception de la douleur, régulation des fonctions cardiovasculaires, gastro-intestinales et hépatiques). Les effets psychotropes bien connus du Δ9THC qui sont véhiculés par l'activation des récepteurs CB1 [...]
Lire la suiteVariétés de Cannabis: Par Docteur Ethan Russo http://www.cannabis-med.org/index.php?tpl=faq&red=faqlist&id=172&lng=fr Les consommateurs de cannabis ont souvent indiqué que les différentes variétés de cannabis produisent des effets variables, que se soit concernant les effets psychoactifs ou les bénéfices thérapeutiques. Les variétés sont généralement désignées comme étant soit Sativa, soit Indica, soit hybrides. Or, ces noms, d’un point de vue commercial, prêtent à confusion. Pour cette raison, la communauté scientifique s’est concentrée sur le Tétrahydrocannabinol (THC) qu’elle considérait comme la principale variable et la seule d’importance. En parallèle, jusqu’à très récemment, les croisements sélectifs des variétés de cannabis, destiné à l’usage récréatif ou à l’usage thérapeutique, [...]
Lire la suiteThe Anti-Inflammatory Properties of Terpenoids from Cannabis Ruth Gallily, Zhannah Yekhtin, and Lumı´r Ondrˇej Hanusˇ Cannabis and Cannabinoid Research, 3, 1, 2018, 282-290. Doi : 10.1089/can.2018.0014 Abstract : Introduction : Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized. The aim of this study was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD). Materials and Methods : Essential oils prepared from three monoecious nonpsychoactive chemotypes of Cannabis were analyzed for their terpenoid content and subsequently studied pharmacologically for their anti-inflammatory properties in [...]
Lire la suiteMedicinal Properties of Cannabis, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain : An Update on Current Evidence and Cannabis Science, Eric P. BARON Headache, July/August 2018, 1139-1186. Background.—Comprehensive literature reviews of historical perspectives and evidence supporting cannabis/ cannabinoids in the treatment of pain, including migraine and headache, with associated neurobiological mechanisms of pain modulation have been well described. Most of the existing literature reports on the cannabinoids Δ9- tetrahydrocannabinol (THC) and cannabidiol (CBD), or cannabis in general. There are many cannabis strains that vary widely in the composition of cannabinoids, terpenes, flavonoids, and other compounds. These components work [...]
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