Plant cannabinoids : a neglected pharmacological treasure trove Raphael Mechoulam British Journal of Pharmacology, 2005, 146, 913–915 doi : 10.1038/sj.bjp.0706415 Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, D9-tetrahydro-cannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest. Keywords : Anandamide; CB1 receptor antagonist; CB2 receptor antagonist; mouse vas deferens; D9 tetrahydrocannabinol; D9-tetrahydrocannabivarin; -(þ)-(R)- WIN55212 Cannabis sativa L. produces more than 60 terpeno-phenols that have not been detected [...]
Lire la suiteEfficacy of Dronabinol for Acute Pain Management in Adults with Traumatic Injury : Study Protocol of A Randomized Controlled Trial Claire Swartwood, Kristin Salottolo, Robert Madayag, David Bar-Or Brain Sciences, 2020, 10, 161, 1-9. Doi : 10.3390/brainsci10030161 Abstract Delta-9-tetrahydrocannabinol (D9-THC) and other cannabinoids present in cannabis (marijuana) have been shown to affect the normal inhibitory pathways that influence nociception in humans. The potential benefits of cannabinoids as an analgesic are likely greatest in hyperalgesic and inflammatory states, suggesting a role as a therapeutic agent for treating acute pain following injury. Dronabinol is a licensed form of D9-THC. The primary objective of this single center randomized [...]
Lire la suiteDe la première vague à la renaissance psychédélique ATHS 2019, Biarritz, 1-4 octobre 2019 Dr Bertrand LEBEAU LEIBOVICI Les psychédéliques « classiques » A l’exception du LSD, ce sont des substances naturelles consommées par certains peuples depuis des millénaires Les psychédéliques « classiques » interagissent avec le récepteur 5HT2a : LSD psilocybine DMT (Diméthyltryptamine) mescaline Une définition plus large des psychédéliques : Les entactogènes et empathogènes: MDMA, MDA, 2-CB, 2C-T-7 etc. Les substances dissociatives antagonistes NMDA : kétamine, PCP Les substances dissociatives agonistes kappa-opioïdes : ibogaïne et Salvia Divinorum Tryptamines et phényléthylamines : Les psychédéliques sont : soit des tryptamines : LSD, psilocybine, DMT, ibogaïne, bufoténine (5-hydroxy-DMT) soit des phényléthylamines: MDMA, mescaline, MDA, 2C-B etc. La psychiatrie en [...]
Lire la suiteThe Consciousness Research of Stanislav Grof : A Cosmic Portal Beyond Individuality By Richard Yensen, Ph.D. and Donna A. Dryer, M.D., M.P.H. ©1998 Richard Yensen & Donna Dryer I. Introduction Stanislav Grof began his research in Prague, Czechoslovakia, as a psychiatric resident, in the late 1950’s. His initial observations seemed to confirm and offer a laboratory proof for many of the basic tenets of Freudian psychoanalytic thought. At that time his conclusion was politically unsettling because psychoanalysis was repressed in the iron curtain countries. Forty years later the outcome of Grof’s continued research is a theoretical framework for understanding human consciousness. His theory has [...]
Lire la suiteBibliographie : Cannabinoïdes et autismes / TED / psychoses infantiles. Dr Christian Sueur, GRECC, version actualisée avril 2020.
Lire la suiteCOVID-19 and people who use drugs Context Risks for people who use drugs Considerations for service providers References More information Acknowledgements Download as PDF The implications of COVID-19 for people who use drugs (PWUD) and drug service providers The situation regarding responses to the COVID-19 outbreak is rapidly evolving. Up-to-date information can be found in the guidelines prepared by national public health sources and the regular updates from the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO). This document is also available as a PDF. Last updated: 25 March 2020 Context – the coronavirus outbreak (COVID-19) in the EU People [...]
Lire la suiteRenaud Colson est docteur en droit, diplômé des universités de Nantes et de Cardiff, et des Facultés Saint-Louis de Bruxelles. Il est maître de conférences à la faculté de droit et des sciences politiques de l’université de Nantes, British Academy visiting fellow et honorary lecturer à l’université de Cardiff. Il a développé ses recherches à l’Institut universitaire européen (Florence, de 2011 à 2013), à l’université Jawaharlal Nehru (New Delhi, 2016), à l’Institut universitaire sur les dépendances (Montréal, 2018), et au Max-Planck-Institut für ausländisches und internationales Privatrecht (Hambourg, 2019). Renaud Colson travaille à la croisée de diverses disciplines (droit processuel, droit pénal européen, [...]
Lire la suiteMescal : A New Artificial Paradise Havelock Ellis The Contemporary Review, Jan 1898 https://erowid.org/plants/peyote/peyote_article1.shtml It has been known for some years that the Kiowa Indians of New Mexico are accustomed to eat, in their religious ceremonies, a certain cactus called Anhalonium Lewinii, or mescal button. Mescal -- which must not be confounded with the intoxicating drink of the same name made from an agave -- is found in the Mexican Valley of the Rio Grande, the ancestral home of the Kiowa Indians, as well as in Texas, and is a brown and brittle substance, nauseous and bitter to the taste, composed mainly of the [...]
Lire la suiteMedicinal Plants of the Russian Pharmacopoeia; their history and applications Alexander N. Shikov, Olga N. Pozharitskaya, Valery G. Makarov, Hildebert Wagner, Rob Verpoorte, Michael Heinrich Journal of Ethnopharmacology, 2014, 154, 481–536 Doi : 10.1016/j.jep.2014.04.007 Ethnopharmacological relevance : Due to the location of Russia between West and East, Russian phytotherapy has accumulated and adopted approaches that originated in European and Asian traditional medicine. Phytotherapy is an official and separate branch of medicine in Russia; thus, herbal medicinal preparations are considered official medicaments.The aim of the present review is to summarize and critically appraise data concerning plants used in Russian medicine.This review describes the history of herbal [...]
Lire la suitePublications du Dr William Lowenstein sur le cannabis 2009 : Dossier cannabis Thérapeutique : "le regard de William Lowenstein", SWAPS, 4 trimestre 2009, n° 57. https://www.pistes.fr/swaps/57_213.htm 2012 : Salles de shoot et cannabis : seringues propres ou kalachnikovs, Slate.fr, 31 octobre 2012 http://www.slate.fr/tribune/64217/salles-de-shoot-cannabis-seringues-propres-kalachnikovs 2014 : « Légalisation du cannabis : 50% des gains doivent revenir au sanitaire », SOS Addictions, 22 décembre 2014. http://sos-addictions.org/actualite-des-addictions/william-lowenstein-legalisation-du-cannabis-50-des-gains-doivent-revenir-au-sanitaire 2016 : La guerre au cannabis est une mauvaise politique, Slate.fr, 14 avril 2016 http://www.slate.fr/story/116741/cannabis-guerre-mauvaise-politique 2018 : Cannabis : "La prohibition est une mauvaise politique", selon le président de SOS Addictions http://www.magalicroset-calisto.com/2018/10/cannabis-la-prohibition-est-une-mauvaise-politique-w.lowenstein-president-de-sos-addictions.html https://www.europe1.fr/societe/cannabis-la-prohibition-est-une-mauvaise-politique-selon-le-president-de-sos-addictions-3781289
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