The Intricate Influence of the Placebo Effect on Medical Cannabis and Cannabinoids Jürg Gertsch Medical Cannabis Cannabinoids, 2018, 1, 60–64 Doi : 10.1159/000489291 Abstract The botanical drug cannabis flos (inflorescence of Cannabis sativa L.) has a unique popular status as being a potent recreational drug and bona fide universal remedy (panacea). Generally, cannabinoids exert therapeutic effects in a broad range of pathophysiologies related to inflammation, pain, metabolic and stress-related conditions in preclinical animal models. However, the translation of such data to humans still lacks an evidence-based foundation. Motivated by the booming cannabis manufacturing industry and the increasing worldwide self-therapy by patients, there are cumulative accounts [...]
Lire la suiteEuro consortium will submit consolidated Novel Food application HempToday® May 5, 2020 https://hemptoday.net/euro-novel-food-consortium/ A consortium led by the European Industrial Hemp Association (EIHA), will resort to the current EU food safety approval process for hemp foods and extracts while continuing to challenge those rules.Stakeholders in the consortium, which is being organized as a limited liability company, EIHA projects GmbH, disagree with changes made in January 2019 to the EU’s Novel Food catalogue which re-classified hemp leaves and flowers as well as extracts derived from those plant parts – including CBD – as Novel Foods.But with EU officials and some Member States failing to [...]
Lire la suiteBeneficial Effects of Cannabis on Blood Brain Barrier Function in HIV Ronald J Ellis 1 , Scott Peterson 2 , Mariana Cherner 1 , Erin Morgan 1 , Rachel Schrier 1 , Bin Tang 1 , Martin Hoenigl 1 , Scott Letendre 1 , Jenny Iudicello 1 Clinical infectious diseases, 2020 Apr 16, ciaa437. Doi : 10.1093/cid/ciaa437 Abstract Background: HIV infection leads to blood-brain barrier (BBB) dysfunction that does not resolve despite viral suppression on antiretroviral therapy and is associated with adverse clinical outcomes. In preclinical models, cannabis restores BBB integrity. Methods: We studied people with HIV (PWH) and HIV- individuals who had used cannabis [...]
Lire la suiteAstrocytes in rapid ketamine antidepressant action Matjaž Stenovec, Baoman Li, Alexei Verkhratsky, Robert Zorec Neuropharmacology, 2020, 173, 108158 Doi : 10.1016/j.neuropharm.2020.108158 H I G H L I G H T S • Ketamine inhibits calcium signalling and enhances cAMP production in astroglia. • Ketamine suppresses exocytosis of gliosignalling molecules and Kir4.1. • Ketamine elevates cholesterol content in the plasmalemma specifically in astrocytes. A B S T R A C T Ketamine, a general anaesthetic and psychotomimetic drug, exerts rapid, potent and long-lasting antidepressant effect, albeit the cellular and molecular mechanisms of this action are yet to be discovered. Besides targeting neuronal NMDARs fundamental for synaptic transmission, ketamine affects the [...]
Lire la suiteAntidepressant mechanisms of ketamine: Focus on GABAergic inhibition Bernhard Luscher, Mengyang Fenga, Sarah J. Jefferson Advances in Pharmacology, 2020 doi : 10.1016/bs.apha.2020.03.002 Contents 1. Introduction 3 2. Molecular targets of subanesthetic ketamine and its metabolites 6 3. Insights from ketamine indicate a key role for reduced GABAergic inhibition in the pathophysiology of major depression 7 3.1 Antidepressant efficacy of ketamine is controlled by imbalances between neural excitation and inhibition 7 3.2 Chronic imbalances of neural excitation and inhibition lead to homeostatic downregulation of glutamatergic synapses that compromises normal neuronal communication 9 3.3 Chronic imbalances between neural excitation and inhibition lead to defects in GABAergic inhibition that delimit spontaneous recovery from [...]
Lire la suiteLe National favorable aux tests de distribution de cannabis bio Mardi, 02 juin 2020 Dépêche ATS Berne Des tests de distribution de cannabis récréatif biologique devraient avoir lieu en Suisse. Le National y est favorable. Il a précisé mardi les contours de ces expériences qui pourraient être menées dans de grandes villes helvétiques. En décembre, la Chambre du peuple, dans sa nouvelle composition, avait accepté d'entrer en matière sur cette modification de la loi sur les stupéfiants contre l'avis de sa commission. Celle-ci a dû revoir sa copie et s'est ralliée dans les grandes lignes au projet du gouvernement. Le dossier n'a pas [...]
Lire la suiteCannabis (Marijuana) : Psychoactive Properties, Addiction, Therapeutic Uses, and Toxicity Sumanasekera W.K. and Spio K. Journal of Addictive Behaviors, Therapy and Rehabilitation, 2016, 5, 2, 1-9. Doi : 10.4172/2324-9005.10001562016 Abstract Background and Objectives : To analyze the existing literature on cannabis (marijuana) under several sub topics; history of use, addiction, mechanism of action, therapeutic uses, and adverse effects. Methods : A comprehensive literature search was conducted. Data sources include original research articles, systematic reviews and meta- analysis, and web-based references such as Drug strategy monographs and Merck Index. Data bases such as PubMed and Cinhal was used. References were from 1979 -2016. Hypothesis : Based on the [...]
Lire la suiteLes effets antidépresseurs de la kétamine élucidés Utilisée de longue date comme anesthésique, cette molécule vient d’être autorisée comme antidépresseur aux Etats-Unis. Par Florence Rosier Publié le 16 avril 2019 à 06h00 - https://www.lemonde.fr/sciences/article/2019/04/16/les-effets-antidepresseurs-de-la-ketamine-elucides_5450737_1650684.html La kétamine est une molécule à surprises. Et pas seulement pour ceux qui recherchent ses effets hallucinogènes en la détournant de ses applications médicales. Depuis les années 1970, elle est largement utilisée comme anesthésique à usage humain ou vétérinaire. Mais elle est aussi dotée de puissants effets antidépresseurs, découverts voici plus de vingt ans. Or, ceux-ci viennent d’être doublement reconnus : au plan réglementaire, par la toute-puissante agence américaine du médicament (FDA) ; [...]
Lire la suite5 Ways Quarantine Has Changed the Cannabis Industry Forever Covid-19 lockdown sparks a 'green rush,' changing how consumers shop By T.L. Stanley | May 5, 2020 https://www.adweek.com/digital/5-ways-quarantine-has-changed-the-cannabis-industry-forever/ As cannabis brands emerge from months in quarantine, how will they be changed by the experience? Key insights: New shopping methods aren't just a crisis response. They're also super convenient. Move over, brownies. Demand for next-gen edibles and infused products is skyrocketing. Budget tightening? Meet the new value brands of cannabis. Stuck in quarantine for weeks on end and hoarding necessities, consumers have made their Covid-19 buying preferences extremely clear: toilet paper, frozen pizza, jigsaw puzzles and hand sanitizer. For certain consumers, [...]
Lire la suiteSmoking weed and coronavirus : Even occasional use raises risk of Covid-19 complications By Sandee LaMotte, CNN Updated 1222 GMT (2022 HKT) April 10, 2020 (CNN)If you're smoking weed to ease your stress during the coronavirus pandemic, experts say it's time to think twice. Smoking marijuana, even occasionally, can increase your risk for more severe complications from Covid-19, the disease caused by the novel coronavirus. Coronavirus symptoms: 10 key indicators and what to do "What happens to your airways when you smoke cannabis is that it causes some degree of inflammation, very similar to bronchitis, very similar to the type of inflammation that cigarette [...]
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