New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation, Antioxidant Properties and In Vitro Anticancer Effect Anca Roxana Petrovici, Natalia Simionescu, Andreea Isabela Sandu, Vasile Paraschiv, Mihaela Silion and Mariana Pinteala Antioxidants, 2021, 10, 738. doi : 10.3390/antiox10050738 Abstract : This study aimed to obtain and characterize extracted hemp oil enriched in cannabidiol (CBD) by decarboxylation of cannabidiolic acid (CBDA) and to give new insights into its antioxidant and anticancer effects. Optimization of CBDA decarboxylation in hemp oil was performed, and CBD and CBDA contents and purities were determined by flash chromatography, 1H- and 13C-NMR. The antioxidant properties of CBD-enriched oil were investigated by Fe2+ [...]
Lire la suiteCannabis-related diagnosis in pregnancy and adverse maternal and infant outcomes Gretchen Bandoli, Laura Jelliffe-Pawlowski, Benjamin Schumacher, Rebecca J. Baer, Jennifer N. Felder, Jonathan D. Fuchs, Scott P. Oltman, Martina A. Steurer, Carla Marienfeld Drug and Alcohol Dependence, 2021, 225, 108757. doi : 10.1016/j.drugalcdep.2021.108757 Abstract Background: Cannabis use and cannabis use disorders are increasing in prevalence, including among pregnant women. The objective was to evaluate the association of a cannabis-related diagnosis (CRD) in pregnancy and adverse maternal and infant outcomes. Methods: We queried an administrative birth cohort of singleton deliveries in California between 2011-2017 linked to maternal and infant hospital discharge records. We [...]
Lire la suiteCannabis and cannabinoid use in autism spectrum disorder : a systematic review Estácio Amaro da Silva Junior, Wandersonia Moreira Brito Medeiros, Nelson Torro, João Marçal Medeiros de Sousa, Igor Bronzeado Cahino Moura de Almeida, Filipe Barbosa da Costa, Katiúscia Moreira Pontes, Eliane Lima Guerra Nunes, Marine Diniz da Rosa, Katy Lísias Gondim Dias de Albuquerque Trends in Psychiatry and Psychotherapy, 2021, 1-10. Doi : 10.47626/2237-6089-2020-0149 Abstract Introduction : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction, associated with the presence of restricted and repetitive patterns of behavior, interests, or activities. Cannabis has been used to alleviate [...]
Lire la suiteCannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors Raquel Linge, Laura Jimenez-Sanchez, Leticia Campa, Fuencisla Pilar-Cuellar, Rebeca, Vidal, Angel Pazos, Albert Adell, Alvaro Diaz Neuropharmacology, 2016, 103, 16-26. doi : 10.1016/j.neuropharm.2015.12.017 Abstract Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD following acute and chronic administration in the olfactory bulbectomy mouse model of depression (OBX), and investigated the underlying mechanism. For this purpose, we [...]
Lire la suiteCannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice Aymen H. Sadaka, Ana G. Ozuna1, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai‑Ling Li, Andrea G. Hohmann and Craig F. Ferris Journal of Translationnal Medicine, 2021, 19, 220, 1-16. Doi : 10.1186/s12967-021-02891-6 Abstract Background : The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? We hypothesized that CBD would produce a dose-dependent reduction in brain activity and functional coupling in [...]
Lire la suiteTransient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth Calvin Ly, Alexandra C. Greb, Maxemiliano V. Vargas, Whitney C. Duim, Ana Cristina G. Grodzki, Pamela J. Lein, and David E. Olson ACS Pharmacology and Translational Science, 2020. doi : 10.1021/acsptsci.0c00065 ABSTRACT Cortical neuron atrophy is a hallmark of depression and includes neurite retraction, dendritic spine loss, and decreased synaptic density. Psychoplastogens, small molecules capable of rapidly promoting cortical neuron growth, have been hypothesized to produce long-lasting positive effects on behavior by rectifying these deleterious structural and functional changes. Here we demonstrate that ketamine and LSD, psychoplastogens from two structurally distinct chemical classes, promote [...]
Lire la suiteIACM-Bulletin du 28 Juin 2021 Science/Homme: Selon une enquête, la consommation du cannabis est associée à une meilleure qualité de vie chez les patients souffrant de douleurs. Science/Homme: Le cannabis améliore la qualité de vie des patients atteints d’un cancer du cerveau, selon une étude clinique. Science/Homme: De faibles doses de THC peuvent améliorer les effets analgésiques des opioïdes selon une étude expérimentale sur la douleur. Science/Homme: Une découverte archéologique de graines de cannabis dans un cimetière suggère l'utilisation médicale du cannabis en Chine il y a 2000 ans. Science/Homme: Un extrait de cannabis a [...]
Lire la suiteIACM-Bulletin du 15 Juin 2021 Science/Homme: Le cannabis peut être efficace pour réduire les symptômes comportementaux associés à la démence. Science/Homme: Plus de deux tiers des médecins aux États-Unis estiment que le cannabis a une valeur médicale. Science: Mise à jour des connaissances sur les composés du cannabis, dont 125 cannabinoïdes. Science/Homme: La consommation de cannabis n'influerait pas gravement l'évolution de la schizophrénie, mais pourrait augmenter le risque de rechute. En bref Un coup d'œil sur le passé Science/Homme: Le cannabis peut être efficace pour réduire les symptômes comportementaux associés à la [...]
Lire la suiteA single dose of psilocybin increases synaptic density and decreases 5-HT2A receptor density in the pig brain Nakul Ravi Raval, Annette Johansen, Lene Lundgaard Donovan, Nidia Fernandez Ros, Brice Ozenne, Hanne Demant Hansen, Gitte Moos Knudsen Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 30 November 2020 doi : 10.20944/preprints202011.0742.v1 Abstract : A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5 HT2AR) agonist, may be associated with antidepressant effects. The mechanism behind its antidepressive action is unknown but could be linked to increased synaptogenesis and down-regulation of cerebral 5-HT2AR. Here, we investigate if a single psychedelic dose of psilocybin changes synaptic vesicle protein 2A [...]
Lire la suiteCannabis thérapeutique : une certitude et de nombreuses interrogations Yann BISIOU, maître de conférences en droit privé et sciences criminelles, CORHIS, EA 7400, université Paul-Valéry, Montpellier in "Politique de Santé, Santé Publique, Economie de la Santé", G. Delande, Ph Amiel, R. Bourret, J. Bachri, Chap. 10, Revue Droit et Santé, Janvier 2020, 93, 3-10. C’est maintenant une certitude, la France va expérimenter le cannabis thérapeutique à partir de 2020. Dans le cadre du projet de loi de financement de la Sécurité sociale, l’Assemblée nationale a en effet voté à l’unanimité un amendement pour autoriser cette expérimentation. Même si le Sénat a rejeté dans sa totalité le [...]
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