What Should I KnowAboutMedical Cannabis ? Michael A. Incze, MD, MSEd; Deepika Slawek, MD,MS, MPH; Chinazo O. Cunningham, MD,MS The JAMA Internal Medicine Patient Page, Online : February 11, 2020 doi : 10.1001/jamainternmed.2020.0018 What Is Cannabis and How Is It Used ? • Cannabis (ie, marijuana) is a plant that contains a complex mixture of chemicals called cannabinoids. Examples of cannabinoids include tetrahydrocannabinol (THC) and cannabidiol (CBD). • Whereas THC is primarily responsible for the psychoactive effects (euphoria) of cannabis, CBD may decrease pain but causes far fewer psychoactive effects than THC. • Cannabis is used medically as purified cannabinoids (eg, CBD), synthetic cannabinoids (eg, dronabinol), or [...]
Lire la suiteSécurité routière & stupéfiants : Pour des tests de dépistage comportementaux Lettre ouverte aux députés et au gouvernement Le collectif Police Contre la Prohibition Paris, le 11 février 2020 Sur la route, tout comportement susceptible dexposer la sécurité dautrui, des passagers de son véhicule, et de soi-même, constitue une infraction prévue par le Code de la route. Parmi ces infractions sévèrement punies : la consommation de substances psychoactives. La première concernée est lalcool. La loi prévoit une tolérance non nulle et mesurable, au-delà de laquelle le conducteur est réputé avoir conduit sous l'empire d'un état alcoolique, son état de conscience étant altéré et incompatible avec [...]
Lire la suiteClinical and Toxicological Profile of NBOMes : A Systematic Review Nino Cesar Marchi, Juliana Nichterwitz Scherer, Letícia Schwanck Fara, Lysa Remy, Rafaela Ornel, Monique Reis, Amanda Zamboni, Mariana Paim, Taís Regina Fiorentin, Carlos Alberto Yasin Wayhs, Lisia Von Diemen, Flavio Pechansky, Felix Henrique Paim Kessler, Renata Pereira Limberger Psychosomatics, 2019 Mar - Apr, 60, (2), 129-138. doi : 10.1016/j.psym.2018.11.002 Background : NBOMes are a new class of potent hallucinogens widely present in illicit drugs. Little is known about this class of drugs, regarding its detection and clinical manifestations of intoxication. Objective : This study aims to enhance care involving NBOMes by reviewing the literature on their [...]
Lire la suiteThe Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Carla Pallavicini, Fire Erowid, Earth Erowid and Enzo Tagliazucchi Frontiers in Integrative Neuroscience, 2018, 12, 54. doi : 10.3389/fnint.2018.00054 Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user (“set”) and the surroundings (“setting”). The observation of crosstolerance and a series [...]
Lire la suiteModern Clinical Research on LSD Matthias E Liechti Neuropsychopharmacology, 2017, 42, 2114–2127. doi : 10.1038/npp.2017.86 All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients. In a controlled setting, LSD acutely induced bliss, audiovisual synesthesia, altered meaning of perceptions, derealization, depersonalization, and mystical experiences. These subjective effects of LSD were mediated by the 5-HT2A receptor. LSD increased feelings of closeness to others, openness, trust, and suggestibility. LSD impaired the recognition of sad and fearful faces, reduced left [...]
Lire la suiteAyahuasca : l’importance du cadre et de l’intention lors de prise de psychédéliques Jean-Charles Bernard Psychotropes, 2016, 2, Vol. 22, pages 81 à 100 ISSN 1245-2092, ISBN 9782807390485 Résumé : La boisson amazonienne ayahuasca génère de profonds états modifiés de conscience et s’ingère “traditionnellement” lors de rituels dans un but précis : apprentissage, guérison, divination… Le sens de l’expérience est consubstantiel au rituel dans la culture chamanique où l’accès au “monde-autre” appartient au champ des possibles. La globalisation de cette boisson a vu naître de nouveaux usages, tout d’abord dans les religions de l’ayahuasca au Brésil et dans les centres néo-psychothérapiques en Amérique du [...]
Lire la suitePsychedelics and potential benefits in “healthy normals”: A review of the literature Sam GANDY Journal of Psychedelic Studies, 2019, 3, (3), 280–287. Doi : 10.1556/2054.2019.029 We are in the midst of a psychedelic research renaissance. With research examining the efficacy of psychedelics as a treatment for a range of mental health indications still in its early stages, there is an increasing body of research to show that careful use of psychedelics can yield a variety of benefits in “healthy normals” and so lead to “the betterment of well people.” Psychedelics have been found to modulate neuroplasticity, and usage in a supportive setting can result [...]
Lire la suiteNeurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression Paulo R. Shiroma, C. Sophia Albott, Brian Johns, Paul Thuras, Joseph Wels and Kelvin O. Lim The International Journal of Neuropsychopharmacology, 2014, Volume 17, Issue 11, 1805–1813, Doi : 10.1017/S1461145714001011 Abstract The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid anti-depressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive performance and change in severity of depressive symptoms through six ketamine infusions, (2) examine the neurocognitive effects after completion of serial infusions and whether changes were associated to [...]
Lire la suiteA phenomenology of subjectively relevant experiences induced by ayahuasca in Upper Amazon vegetalismo tourism Tom John Wolff, Simon Ruffell, Nigel Netzband and Torsten Passie Journal of Psychedelic Studies, 2018 Doi : 10.1556/2054.2019.007 Aims : This heuristic study reports observations on the phenomenology of ayahuasca experiences of nine foreign tourist participants of an ayahuasca retreat in Peru. Methods : Narrative interviews, reflecting individual experiences after ayahuasca “night ceremony,” have been analyzed by qualitative content analysis using a data-driven strategy in order to extract themes and categories inherent in the interviews. Previously, a demographic questionnaire was given. The dose–response connection was uncontrolled, which is typical for this [...]
Lire la suiteThe therapeutic role of Cannabidiol in mental health : a systematic review Rabia Khan, Sadiq Naveed, Nadeem Mian, Ania Fida, Muhammad Abdur Raafey and Kapil Kiran Aedma Journal of Cannabis Research, 2020, 2, 2 doi : 10.1186/s42238-019-0012-y Abstract Background : The therapeutic application of cannabidiol (CBD) is gaining interest due to expanding evidence for its use. Objective : To summarize the clinical outcomes, study designs and limitations for the use of CBD and nabiximols (whole plant extract from Cannabis sativa L. that has been purified into 1:1 ratio of CBD and delta-9- tetrahydrocannabinol) in the treatment of psychiatric disorders. Materials and method : A systematic review was [...]
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