Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal Francisco Navarrete, Auxiliadora Aracil-Fernández and Jorge Manzanares British Journal of Pharmacology, 2018. Doi : 10.1111/bph.14226 BACKGROUND AND PURPOSE Cannabidiol (CBD) represents a promising therapeutic tool for treating cannabis use disorder (CUD). This study aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous cannabinoid withdrawal. EXPERIMENTAL APPROACH Spontaneous cannabinoid withdrawal was evaluated 12 h after cessation of CP-55,940 treatment (0.5 mg·kg1 every 12 h, i.p.; 7 days) in C57BL/6J mice. The effects of CBD (5, 10 and 20 mg·kg1, i.p.) on withdrawal-related behavioural signs were evaluated by [...]
Lire la suiteCannabis is Not a Suitable Human Coronavirus Treatment Marc Moulin March 20, 2020 https://www.rxleaf.com/cannabis-not-good-human-coronavirus-treatment/ Using cannabis as a human coronavirus treatment may make symptoms worse. Cannabis is great for a lot of things. For example, many physical conditions see symptom abatement with cannabinoid treatment. Additionally, there is adequate, and in some cases, strong, scientific evidence to support consuming cannabis for therapeutic relief. Unfortunately, fighting off influenza-like viruses is not one of them. It’s important to note that there is absolutely no evidence to suggest that cannabis is an effective human coronavirus treatment. On the contrary, researchers from Michigan State University provide recent evidence to demonstrate potentially harmful [...]
Lire la suiteAddiction au cannabis, confinement et détention Jean Michel Delile, David Saint Vincent, Laurent Michel, Patrick Veteau Fédération Addiction, mars 2020 Cannabis et dépendance Longtemps, beaucoup ont pensé que le cannabis n’était pas une drogue (dangereuse), ou alors seulement une drogue « douce », au sens où il n’entrainait pas de syndrome physique de manque, à la différence de l’alcool, des opiacés ou des benzodiazépines… Il a fallu beaucoup de temps aux usagers et aux médecins pour réaliser que l’évidence de la souffrance des patients démontrait que la clef de l’addiction en tant que trouble était plus dans le désir/besoin irrépressible de consommer que dans [...]
Lire la suiteImmune Responses Regulated by Cannabidiol James M. Nichols and Barbara L.F. Kaplan Cannabis and Cannabinoid Research, 2019, Volume X, Number X Doi : 10.1089/can.2018.0073 Abstract Introduction : Cannabidiol (CBD) as Epidiolex (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and [...]
Lire la suiteLSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation Rainer Kraehenmann, Dan Pokorny, Helena Aicher, Katrin H. Preller, Thomas Pokorny, Oliver G. Bosch, Erich Seifritz and Franz X. Vollenweider Frontiers in Pharmacology, 2017, Volume 8, Article 814, 1-9. Doi : 10.3389/fphar.2017.00814 Rationale : Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking – an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces [...]
Lire la suiteMDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor Drew J. Puxty, Johannes G. Ramaekers, Rafael de la Torre, Magí Farré, Neus Pizarro, Mitona Pujadas and Kim P. C. Kuypers Frontiers in Pharmacology, 2017, Volume 8, Article 455 Doi : 10.3389/fphar.2017.00455 Previous research has shown that a single dose of MDMA induce a dissociative state, by elevating feelings of depersonalization and derealization. Typically, it is assumed that action on the 5-HT2A receptor is the mechanism underlying these psychedelic experiences. In addition, other studies have shown associations between dissociative states and biological parameters (heart rate, cortisol), which are elevated by MDMA. In order to investigate [...]
Lire la suiteCannabis and Coronavirus : What Cannabis Patients Want to Know Jennifer Grant https://www.rxleaf.com/cannabis-and-coronavirus-what-cannabis-patients-want-to-know/ February 17, 2020 There is evidence that cannabis can reduce viral load in HIV, can it help COVID-19 patients? At the time of writing, there were 69, 287 confirmed cases of the coronavirus and 1670 deaths. With the rapid escalation of the outbreak, these numbers will surely be outdated by the time of publication. With several regions heading into states of emergencies, including quarantine, nervous travelers are looking for anti viral herbs to reduce the chance of infection. Patients have asked us: What about cannabis? There have been rumors about successful treatments for coronavirus, [...]
Lire la suiteDrogue : touché par le virus, le trafic en pleine mutation Par Emmanuel Fansten et Charles Delouche — 26 mars 2020 à 19:56 Libération, 26 mars 2020 à 19:56 https://www.liberation.fr/france/2020/03/26/drogue-touche-par-le-virus-le-trafic-en-pleine-mutation_1783229?xtor=EREC-25&actId=ebwp0YMB8s1_OGEGSsDRkNUcvuQDVN7a57ET3fWtrS8ltxjKGe9elSCGoITXqyaf&actCampaignType=CAMPAIGN_MAIL&actSource=501802 Malgré la pénurie qui guette avec le confinement, les dealers s’adaptent pour poursuivre leur activité : offres sur le Darknet, livraisons via des plateformes d’appels… Et profitent de la saturation des services de police et de justice, débordés par les affaires prioritaires. Drogue : touché par le virus, le trafic en pleine mutation En bordure du périphérique parisien, les allées du marché aux puces de Saint-Ouen, en Seine-Saint-Denis, sont quasi désertes mardi après-midi, une semaine [...]
Lire la suiteWhere Is Marijuana Legal in the US? [2020] https://www.testclear.com/Where-Is-Marijuana-Legal-in-the-US-2020.aspx Marijuana continues to tread between legal and illegal status, depending on where you are looking in the US and for what purpose you are using the substance. Where Is Marijuana Legal? Medical Marijuana Recreational Marijuana Decriminalized THC-low, CBD-High Allowed Table of Contents Where Is Marijuana Legal? Where Is Marijuana Decriminalized? What Are State Marijuana Laws? What Is the Impact of Marijuana Legalization? What Is the Cole Memorandum? Is Marijuana Legal at the Federal Level? What’s Next for the Legalization of Marijuana? Where Does the Public Stand on Marijuana? What Can You Do? As far as the [...]
Lire la suiteAvec le confinement: beaucoup de syndromes de manque Benjamin ROLLAND https://www.addictolyon.fr/post/avec-le-confinement-beaucoup-de-syndromes-de-manque Addictolyon, 19/03/2020, Mis à jour : il y a 4 jours Avec le #confinement lié au #COVID19, les trafics de substances semblent s'être fortement réduits. Résultat: en ville, à l'hôpital, en prison, de nombreux syndromes de manque apparaissent. Afin de faciliter la reconnaissance et la prise en charge des syndrome de sevrage chez les patients, voici un petit document explicatif du repérage et du traitement des syndrome de sevrage à catégories importantes de substance: #tabac, #cannabis, et #opioïdes
Lire la suite