A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol : Δ9-Tetrahydrocannabiphorol Cinzia Citti, Pasquale Linciano, Fabiana Russo, Livio Luongo, Monica Iannotta, Sabatino Maione, Aldo Laganà, Anna Laura Capriotti, Flavio Forni, Maria Angela Vandelli, Giuseppe Gigli & Giuseppe Cannazza Scientific Reports, 2019, 9, 20335 doi : 10.1038/s41598-019-56785-1 2 (-)-Trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the biological activity of this cannabinoid. In particular, synthetic analogues of Δ9-THC with a longer side chain have shown cannabimimetic properties far higher than Δ9-THC itself. [...]
Lire la suiteBibliographie Cannabinoïdes et Opiacés Dr Christian Sueur, GRECC, janvier 2020.
Lire la suiteHenri Michaux et les gouffres (à propos de l’expérience mescalinienne) François Emmanuel « Moi n’est jamais que provisoire » (Plume). « J’écris pour me parcourir… » annonçait Henri Michaux. À l’hiver 1954 (il a cinquante-cinq ans) il a amplement parcouru le monde, descendu en pirogue un affluent de l’Amazone, promené son étrangeté en Inde, en Chine, en Malaisie…, ramené de ces pays lointains des notations buissonnières, éparses, décalées, des fables drolatiques. Çà et là il s’est fait entomologiste fantasque ou zoologiste d’animaux fantastiques. Toujours curieux de l’ailleurs mais toujours un peu déçu, il a délaissé ces contrées réelles pour d’autres imaginaires, s’est lancé [...]
Lire la suiteChanging landscape of cannabis : novel products, formulations, and methods of administration Tory R Spindle, Marcel O Bonn-Miller and Ryan Vandrey Current Opinion in Psychology, 2019, 30, 98–102 Doi : 10.1016/j.copsyc.2019.04.002 Abstract Laws regulating cannabis have changed radically in the U.S. and abroad. Historically, users smoked dried cannabis flowers that contained D9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, as the principal product constituent. Coincident with cannabis legalization and increased interest in medicinal use of the plant, there is now an expansive retail cannabis marketplace with novel cannabis products, formulations, and methods of administration. In this review, we describe emergent cannabis product chemotypes (e.g. THC-dominant, [...]
Lire la suiteThe health and social effects of nonmedical cannabis use World Health Organization, 2016. CONTENTS Foreward. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . v Acknowledgements .. . . . . . . . . . . . . . . . . . . [...]
Lire la suiteAssociation Between Recreational Cannabis Use and Cardiac Structure and Function Mohammed Y. Khanji, Magnus T. Jensen, Asmaa A. Kenawy, Zahra Raisi-Estabragh, Jose M. Paiva, Nay Aung, Kenneth Fung, Elena Lukaschuk, Filip Zemrak, Aaron M. Lee, Ahmet Barutcu, Edd Maclean, Jackie Cooper, Stefan K. Piechnik, Stefan Neubauer and Steffen E. Petersen JACC : Cardiovascular Imaging, 2019. Doi : 10.1016/j.jcmg.2019.10.012 LETTER TO THE EDITOR Cannabis is one of the most widely produced and consumed recreational drugs in the world, with over 192 million global users (1). The World Health Organization has warned against the potential harmful health effects of nonmedicinal cannabis use and highlighted the need for more [...]
Lire la suiteAssociation Between Recreational Marijuana Legalization in the United States and Changes in Marijuana Use and Cannabis Use Disorder From 2008 to 2016 Magdalena Cerdá, DrPH; Christine Mauro, PhD; Ava Hamilton, BA; Natalie S. Levy, MPH; Julián Santaella-Tenorio, DrPH; Deborah Hasin, PhD; Melanie M.Wall, PhD; Katherine M. Keyes, PhD; Silvia S. Martins, MD, PhD JAMA Psychiatry, 2019. doi : 10.1001/jamapsychiatry.2019.3254 IMPORTANCE : Little is known about changes in marijuana use and cannabis use disorder (CUD) after recreational marijuana legalization (RML). OBJECTIVES : To examine the associations between RML enactment and changes in marijuana use, frequent use, and CUD in the United States from 2008 to 2016. DESIGN, SETTING, AND [...]
Lire la suiteAssociations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes : A Systematic Review Divya Ravi, MD, MPH; Mehrnaz Ghasemiesfe, MD; Deborah Korenstein, MD; Thomas Cascino, MD; and Salomeh Keyhani, MD, MPH Annals of Internal Medicine, 2018, 168, (3), 187-194. doi : 10.7326/M17-1548 Annals.org Abstract Background : Marijuana use is increasing in the United States, and its effect on cardiovascular health is unknown. Purpose : To review harms and benefits of marijuana use in relation to cardiovascular risk factors and clinical outcomes. Data Sources : PubMed, MEDLINE, EMBASE, PsycINFO, and the Cochrane Library between 1 January 1975 and 30 September 2017. Study Selection : Observational studies that were published [...]
Lire la suiteAntidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression Eun-Sang Hwang, Hyun-Bum Kim, Seok Lee, Min-Jeong Kim, Kwan-Joong Kim, Gaeul Han, Se-Young Han, Eun-A Lee, Jeong-Hee Yoon, Dae-Ok Kim, Sungho Maeng, Ji-Ho Park Behavioural Brain Research, 2020, 380, 112439 doi : 10.1016/j.bbr.2019.112439 A B S T R A C T Chronic stress is depressogenic by altering neurotrophic and neuroinflammatory environments of the organism. The endocannabinoid system controls cognitive and emotional responses related with stress through the interaction with endocannabinoid receptors. β-Caryophyllene (BCP) is a CB2 agonist that exhibited anti-inflammatory, analgesic effects but minimal psychoactive effects. To test if BCP exhibits antidepressant-like action, animals were chronically restrained with additional [...]
Lire la suiteBibliographie Cannabis et Troubles cardio-vasculaires Dr Christian SUEUR, GRECC, 2e édition, janvier 2020. Actuellement, les méta-analyses ne montrent pas d'augmentation significative des pathologies cardiovasculaire chez les consommateurs de cannabis. (cf en particulier la méta-analyse de Divya RAVI et coll., Annals of Internal Medicine, 2018). Quoiqu'il en soit, l'existence de facteurs de risques liés à la consommation de cannabis fumé est semble-t-il incontestable; de même, les risques sont vraisemblablement augmentés chez les sujets prédisposés, présentant des pathologies cariaques, vasculaires, des troubles de l'excitabilité cardiaque ou de la tension artérielle. La plupart des "Case Report" consistent en des accidents par sténose vasculaire, cérébrale ou cardiaque, [...]
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