A tale of two cannabinoids : The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol Ethan Russo & Geoffrey W. Guy Medical Hypotheses, 2006, 66, 234–246 doi : 10.1016/j.mehy.2005.08.026 Summary This study examines the current knowledge of physiological and clinical effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are explored, such as the capability of THC and CBD to act as anti-inflammatory substances independent of cyclo-oxygenase (COX) inhibition. CBD is demonstrated to antagonise some undesirable effects of THC including intoxication, sedation and tachycardia, while contributing analgesic, anti-emetic, [...]
Lire la suiteInteraction of maternal choline levels and prenatal Marijuana's effects on the offspring Camille Hoffman, Sharon K. Hunter, Angelo D'Alessandro, KathleenNoonan et al. Psychological Medicine, 2019 Doi : https://doi.org/10.1017/S003329171900179X Published online by Cambridge University Press: 31 July 2019 Abstract Background : This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Methods : Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about [...]
Lire la suiteCannabis à visée thérapeutique : Projet d’expérimentation Comité scientifique spécialisé temporaire « évaluation de la pertinence et de la faisabilité de la mise à disposition du cannabis thérapeutique en France » 27/06/2019 Dans la suite de l’avis du Comité scientifique spécialisé temporaire « évaluation de la pertinence et de la faisabilité de la mise à disposition du cannabis thérapeutique en France », il a été décidé la mise en place d’une expérimentation sous l’égide de l’ANSM, ciblant l’utilisation du cannabis à des fins thérapeutiques dans certaines indications ou situations cliniques. L’objectif principal de la phase expérimentale est d’évaluer, en situation réelle, les recommandations du [...]
Lire la suiteCannabis and the developing brain : Insights from behavior Viviana Trezza, Vincenzo Cuomo, Louk J.M.J. Vanderschuren European Journal of Pharmacology, 2008, 585, 441-452. Doi : 10.1016/j.ejphar.2008.01.058 A B S T R A C T The isolation and identification, in 1964, of delta-9-tetrahydrocannabinol (THC), the primary psycho-active compound in cannabis, opened the door to a whole new field of medical research. The exploration of the therapeutic potential of THC and other natural and synthetic cannabinoid compounds was paralleled by the discovery of the endocannabinoid system, comprising cannabinoid receptors and their endogenous ligands, which offered exciting new insights into brain function. Besides its well-known involvement in specific [...]
Lire la suiteDevelopmental consequences of perinatal cannabis exposure : behavioral and neuroendocrine effects in adult rodents Patrizia Campolongo, Viviana Trezza, Patrizia Ratano, Maura Palmery & Vincenzo Cuomo Psychopharmacology, 2011, 214, 5–15 Doi : 10.1007/s00213-010-1892-x Abstract Rationale : Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial role in brain development, maternal exposure to cannabis derivatives might result in longlasting neurobehavioral abnormalities in the exposed offspring. It is difficult to detect these effects, and their underlying neurobiological mechanisms, in clinical cohorts, because of their intrinsic methodological and interpretative issues. Objectives : The present paper reviews relevant rodent studies examining the [...]
Lire la suiteMalades de Parkinson à Marseille, ils vont tester le cannabis thérapeutique La Provence, 24/1/2020 https://www.laprovence.com/article/societe/5858706/avant-premiere-malades-de-parkinson-a-marseille-ils-vont-tester-le-cannabis-therapeutique.html transmis par principesactifs.fr La prise de cannabis peut-elle soulager certains symptômes moteurs et non-moteurs de la maladie de Parkinson ? "Nous avons de bonnes raisons de le penser mais nous avons besoin de données robustes pour le démontrer", sourit le Pr Olivier Blin, chef du service de pharmacologie clinique de la Timone, à Marseille. Grâce au soutien du centre d’excellence Dhune et de l’association France-Parkinson, son équipe, avec le service de neurologie et de pathologie du mouvement, le CNRS et l’Institut de neurosciences du CHU s’apprêtent à tester la prise de [...]
Lire la suiteAn ontology of psychedelic entity experiences in evolutionary psychology and neurophenomenology Michael James WINKELMAN Journal of Psychedelic Studies, 2018. Doi : 10.1556/2054.2018.002 Background and aims : Psychedelic entity experiences are examined from perspectives of evolutionary psychology and neurophenomenology. Their similarities with other entity experiences illustrate the need for a general biological explanation of entity experiences. Mechanisms are proposed to involve innate modules, operators, and intelligences that underlie ordinary cognitive inferences and provide the basis for supernatural thought. Methods : Comparisons of ayahuasca and dimethyltryptamine (DMT) entity experiences with other types of entity experiences show their fundamental similarities to conceptions of spirit guides, mythological beings, divinities, [...]
Lire la suitePsychedelics in History and World Religions, Editorial Michael James Winkelman Journal of Psychedelic Studies, 2019, 3, (2), pp. 41–42 Doi : 10.1556/2054.2019.021 Recent research has given new hope that psychedelics might provide important tools for treating some of our more intractable ailments. Assessment of the therapeutic applications of psychedelics for various conditions (Winkelman & Sessa, 2019) offers tantalizing promises of what may be seen as miracle cures for their immediate results and effectiveness. As new technologies expand our understandings of the effects of these substances, we are entering a new epoch of understanding the systemic effects of psychedelics on the brain. These findings regarding the [...]
Lire la suiteTherapeutic Applications of Ayahuasca and Other Sacred Medicines Michael J. Winkelman chapter 1, in B. Caiuby Labate and C. Cavnar (eds.) : "The Therapeutic Use of Ayahuasca", Springer-Verlag Berlin Heidelberg 2014 Doi : 10.1007/978-3-642-40426-9_1 Abstract : Therapeutic applications of the psychedelics or hallucinogens found cross-culturally involve treatment of a variety of physical, psychological, and social maladies. Modern medicine has similarly found that a range of conditions may be successfully treated with these agents. The ability to treat a wide variety of conditions derives from variation in active ingredients, doses and modes of application, and factors of set and setting manipulated in ritual. Similarities in effects reported [...]
Lire la suiteTherapeutic Bases of Psychedelic Medicines : Psycho-integrative Effects Michael J. WINKELMAN chapter 1, in "PSYCHEDELIC MEDICINE: SOCIAL, CLINICAL, AND LEGAL PERSPECTIVES" january 2007, pp 1-19. INTRODUCTION For thousands of years, human beings have used medicinal plants to enhance their health and well-being. In cultures around the world, plants commonly referred to as psychedelic, hallucinogens, and entheogens have played central roles in their healing practices. These vision-inducing plants have also played important roles in the religious and spiritual practices of many societies, evoking powerful emotional, cognitive, and therapeutic reactions. These plants that were central to concepts of health, spirituality, and well-being were, however, demonized and rejected [...]
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