Psychedelic Drugs in Biomedicine Evan J. KYZAR, Charles D. NICHOLS, Paul R. GAINETDINOV, David E. NICHOLS, Allan V. KALUEFF Trends in Pharmacological Sciences, 2017, 38, (1), 992-1005 https://doi.org/10.1016/j.tips.2017.08.003 Trends Psychedelic drugs profoundly alter human behavior, acting primarily via agonism at the 5-HT2A receptor in the brain. Research into the mechanisms of psychedelic drugs is experiencing a renaissance after years of stagnation. Animal models show that psychedelic drugs alter a number of crucial molecular mechanisms. Psychedelic drugs cause widespread changes in cognition and brain connectivity. Recent pilot studies show LSD and psilocybin are effective in treating psychiatric disorders and possibly other illnesses. Psychedelic biomedicine is rapidly emerging as an important area [...]
Lire la suiteRole of the Serotonin 5-HT2A Receptor in Learning John A. Harvey Learning & Memory, 2003, 355-362 www.learnmem.org http://www.learnmem.org/cgi/doi/10.1101/lm.60803. This study reviews the role of the serotonin 5-HT2A receptor in learning as measured by the acquisition of the rabbit’s classically conditioning nictitating membrane response, a component of the eyeblink response. Agonists at the 5-HT2A receptor including LSD (d-lysergic acid diethylamide) enhanced associative learning at doses that produce cognitive effects in humans. Some antagonists such as BOL (d-bromolysergic acid diethylamide), LY53,857, and ketanserin acted as neutral antagonists in that they had no effect on learning, whereas others (MDL11,939, ritanserin, and mianserin) acted as inverse agonists in that [...]
Lire la suitePotential Therapeutic Effects of Psilocybin Matthew W. Johnson & Roland R. Griffiths Neurotherapeutics, 2017, 14, 734–740 DOI 10.1007/s13311-017-0542-y Abstract Psilocybin and other 5-hydroxytryptamine2A agonist classic psychedelics have been used for centuries as sacraments within indigenous cultures. In the mid-twentieth century they were a focus within psychiatry as both probes of brain function and experimental therapeutics. By the late 1960s and early 1970s these scientific inquires fell out of favor because classic psychedelics were being used outside of medical research and in association with the emerging counter culture. However, in the twenty-first century, scientific interest in classic psychedelics has returned and grown as a result of [...]
Lire la suiteLe cannabis thérapeutique expérimenté 2 ans à partir de 2020 Par Public Sénat avec l'AFP Vendredi 12 juillet 2019 à 16:06 L’Agence du médicament a donné, jeudi, son accord à une expérimentation du cannabis thérapeutique. Sous l’impulsion d’Esther Benbassa, un débat sur la question avait eu lieu au mois de mai dans l’hémicycle. La sénatrice écologiste se réjouit de cette expérimentation mais regrette la « frilosité » du cadre. Fin 2018, l’Agence du médicament (ANSM) avait mandaté un comité d’experts (CSST) pour lui fournir un projet-cadre d’expérimentation du cannabis thérapeutique. Jeudi, l’ANSM a donc donné son feu vert aux conditions d’une expérimentation qui démarrera [...]
Lire la suiteL’expérimentation du cannabis thérapeutique officiellement autorisée en France Une décision de l’agence française du médicament ouvre la voie à un test en situation réelle réservé aux patients en impasse thérapeutique. Le Monde avec AFP Publié le 11 juillet 2019 à 11h20 - Mis à jour le 11 juillet 2019 à 11h26 Un plant de cannabis thérapeutique, Israël, le 24 janvier 2019. Amir Cohen / REUTERS C’est une nouvelle étape vers l’expérimentation du cannabis thérapeutique en France : l’Agence nationale de sécurité du médicament et des produits de santé (ANSM) a validé jeudi 11 juillet le cadre proposé fin juin par un groupe [...]
Lire la suiteN-Arachidonoyl Dopamine : A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities Urszula Grabiec and Faramarz Dehghani Cannabis and Cannabinoid Research, 2017, 2, (1), 183-196 DOI: 10.1089/can.2017.0015 Abstract N-arachidonoyl dopamine (NADA) is a member of the family of endocannabinoids to which several other N-acyldopamines belong as well. Their activity is mediated through various targets that include cannabinoid receptors or transient receptor potential vanilloid (TRPV)1. Synthesis and degradation of NADA are not yet fully understood. Nonetheless, there is evidence that NADA plays an important role in nociception and inflammation in the central and peripheral nervous system. The TRPV1 receptor, for which NADA is a [...]
Lire la suiteQue s’est-il dit au colloque de l’Assemblée Nationale sur le chanvre bien-être ? Aurélien BERNARD NEWSWEED, Cannabis en France, 17 juillet 2019 https://www.newsweed.fr/que-sest-il-dit-au-colloque-de-lassemblee-nationale-sur-le-chanvre-bien-etre/ © DR Le 11 juillet dernier s’est tenu à l’Assemblée Nationale un colloque sur le chanvre bien-être, à savoir les usages non-industriels du chanvre. Porté par le député de la Creuse Jean-Baptiste Moreau, Joël Labbé (sénateur du Morbihan), Sandrine Le Feur (députée du Finistère), Ludovic Mendes (député de la Moselle) et le Syndicat Professionnel du Chanvre (SPC), il a rassemblé plus de 250 personnes en salle Colbert autour de trois table-rondes. Le colloque s’est soldé par l’annonce par Jean-Baptiste [...]
Lire la suiteLysergic acid diethylamide : a drug of ‘use’ ? Saibal Das, Preeti Barnwal, Anand Ramasamy, Sumalya Sen and Somnath Mondal Therapeutic Advances in Psychopharmacology, 2016, Vol. 6, (3), 214–228 DOI: 10.1177/2045125316640440 Abstract : Lysergic acid diethylamide (LSD), described as a classical hallucinogen, began its journey from the middle of the last century following an accidental discovery. Since then, it was used as a popular and notorious substance of abuse in various parts of the world. Its beneficial role as an adjunct to psychotherapy was much unknown, until some ‘benevolent’ experiments were carried out over time to explore some of its potential uses. But, many [...]
Lire la suitePrevalence and Correlates of Cannabis Use in Outpatients with Serious Mental Illness Receiving Treatment for Alcohol Use Disorders Jordan Skalisky, Emily Leickly, Oladunni Oluwoye, Sterling M. McPherson, Debra Srebnik, John M. Roll, Richard K. Ries, and Michael G. McDonell Cannabis and Cannabinoid Research, 2017, 2, (1), 133-138 DOI: 10.1089/can.2017.0006 Abstract Introduction : People with serious mental illness (SMI) use cannabis more than any other illicit drug. Cannabis use is associated with increased psychotic symptoms and is highly comorbid with alcohol use disorders (AUDs). Despite the national trend toward decriminalization, little is known about the prevalence, correlates, and impact of cannabis use on those with SMI [...]
Lire la suiteCannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults David L. Arndt and Harriet de Wit Cannabis and Cannabinoid Research, 2017, 2, (1), 105-113 DOI: 10.1089/can.2017.0014 Abstract Introduction : Cannabidiol (CBD) is a nonpsychoactive constituent of whole plant cannabis that has been reported to reduce anxiety-like behaviors in both pre-clinical and human laboratory studies. Yet, no controlled clinical studies have demonstrated its ability to reduce negative mood or dampen responses to negative emotional stimuli in humans. The objective of this study was to investigate the effects of CBD on responses to negative emotional stimuli, as a model for its potential anxiety-reducing effects. Materials and [...]
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