Cannabis Withdrawal Nicolas J. Schlienz and Ryan Vandrey I. D. Montoya, S. R. B. Weiss (eds.), Cannabis Use Disorders, https://doi.org/10.1007/978-3-319-90365-1_11 Introduction Drug withdrawal refers to a constellation of symptoms that occur following abrupt cessation of chronic drug use. Though drug withdrawal can occur from stopping use of medication, it is most often encountered within the context of illicit, non-medicinal, drug use. The withdrawal symptoms that emerge following extended and frequent use of abused drugs are a key feature of what define substance use disorders [4, 85]. Further, there is accumulating neurobiological evidence that withdrawal drives the maintenance of problematic substance misuse through a mechanism of [...]
Lire la suiteCase Series: Salvia divinorum as a Potential Addictive Hallucinogen Joseph El-Khoury, Evelyne Baroud The American Journal on Addictions, 2018, 27, 163–165 DOI: 10.1111/ajad.12715 Background and Objective : Recreational use of Salvia divinorum (salvia), a potent, naturally occurring hallucinogen, is on the rise internationally. Despite the paucity of information about its long term health effects, salvia is readily available and generally portrayed as a safe non-addictive substance. Methods and Results : We report on two patients who presented with an enduring and pervasive pattern of salvia use. Discussion and Conclusions : Evaluating patients for salvia use during clinical assessment is strongly encouraged, especially among young polysubstance users. Scientific [...]
Lire la suiteFlavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer Michele Moreau, Udoka Ibeh, Kaylie Decosmo Noella Bih, Sayeda Yasmin-Karim, Ngeh Toyang, Henry Lowe5 and Wilfred Ngwa Frontiers in Oncology, July 2019, Vol. 9, article 660. doi: 10.3389/fonc.2019.00660 Abstract Pancreatic cancer is particularly refractory to modern therapies, with a 5-year survival rate for patients at a dismal 8%. One of the significant barriers to effective treatment is the immunosuppressive pancreatic tumor microenvironment and development of resistance to treatment. New treatment options to increase both the survival and quality of life of patients are urgently needed. This study reports on a new [...]
Lire la suiteThe moderating effect of psychedelics on the prospective relationship between prescription opioid use and suicide risk among marginalized women Elena Argento, Melissa Braschel, Zach Walsh, M. Eugenia Socias and Kate Shannon Journal of Psychopharmacology, 2018, 1–7 DOI : 10.1177/0269881118798610 Abstract Background/aims : Given high rates of depression and suicide among marginalized women, and increasing calls to integrate trauma-informed biomedical and community-led structural interventions, this study longitudinally examines the potential moderating effect of psychedelic use on the relationship between other illicit drug use and suicide risk. Methods : Data (2010–2017) were drawn from a community-based, prospective open cohort of marginalized women in Vancouver, Canada. Extended Cox regression [...]
Lire la suiteEpidemiology of adolescent Salvia divinorum use in Canada Cheryl L. Currie Drug and Alcohol Dependence, 2012, 128, (1-2) DOI: 10.1016/j.drugalcdep.2012.08.008 a b s t r a c t Background : Salvia divinorum is a potent, naturally occurring hallucinogen gaining popularity as a recreational drug in North America. To date, detailed epidemiologic information about the use of this substance among adolescents living outside the United States has been limited. This study provides information on the prevalence and correlates of Salvia divinorum use among adolesecents in Canada using a nationally representative sample. Methods : Data were obtained from a representative sample of 42,179 Canadian adolescents aged 12–17 years living [...]
Lire la suiteSalvia divinorum EMCDDA, 2010. http://www.emcdda.europa.eu/publications/drug-profiles/salvia/fr Chimie Forme physique Pharmacologie Origine Mode de consommation Autres dénominations Analyse Pureté typique Contrôle Prévalence Prix au détail Usage médical Bibliographie Lecture complémentaire Photo: Wikimedia Commons La plante psychotrope Salvia divinorum, ou «Sauge des devins», est un membre rare de la famille des menthes (Lamiaceae; anciennement Labiatae), qui a été caractérisée au milieu du vingtième siècle. La plante est endémique d’une petite région montagneuse de l’État d’Oaxaca (Mexique), où les Indiens mazatèques ingèrent ses feuilles fraîches ou des préparations à base de feuilles lors de rituels divinatoires, de rites de guérison ou à des fins médicales. Depuis la fin [...]
Lire la suiteChapter 1 : You Have a Constitutional Right to Psychedelics. Academic Freedom, Personal Conscience, and Psychotechnologies Thomas B. Roberts From: Ellens, H. J. & T. B. Roberts. 2015. The Psychedelic Policy Quagmire: Health, Law, Freedom, and Society. Santa Barbara, CA. ABC-CLIO. Author’s note: This also applies to the European Charter of Human Rights and to similar national and international statements. Added Mar. 16, 2016. The problem : we do not suppress books and the ideas they contain; we do suppress psychedelic mindstates and the ideas they contain. Censorship is the issue of contention here: intellectual censorship. In this chapter, we’ll spot the single-state fallacy as [...]
Lire la suitePsilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers Boris B Quednow, Michael Kometer, Mark A Geyer and Franz X Vollenweider Neuropsychopharmacology, 2012, 37, 630–640 doi:10.1038/npp.2011.228 The serotonin-2A receptor (5-HT2AR) has been implicated in the pathogenesis of schizophrenia and related inhibitory gating and behavioral inhibition deficits of schizophrenia patients. The hallucinogen psilocybin disrupts automatic forms of sensorimotor gating and response inhibition in humans, but it is unclear so far whether the 5-HT2AR or 5-HT1AR agonist properties of its bioactive metabolite psilocin account for these effects. Thus, we investigated whether psilocybin-induced deficits in automatic and controlled inhibition in healthy [...]
Lire la suiteUse of Marijuana, Meth, Hallucinogens Up in New SAMHSA Survey Damian McNamara Medscape - Aug 22, 2019 Medscape Medical News © 2019 https://www.medscape.com/viewarticle/917131?nlid=131240_2052&src=WNL_mdplsnews_190823_mscpedit_psyc&uac=292598PZ&spon=12&impID=2070816&faf=1 Almost 1 million more Americans ages 12 or older reported using marijuana in their lifetime in 2018 than in 2017, according to new data from a national survey. The Substance Abuse and Mental Health Services Administration (SAMHSA) 2018 National Survey on Drug Use and Health Report notes that approximately 1.2 million more people reported use of hallucinogens, which include LSD, PCP, and Ecstasy, compared with 2017. In addition, about 170,000 more people used methamphetamine. Not all substance use increased year over year. For example, 187,000 fewer adolescent and adult Americans [...]
Lire la suitePsilocybin, Lysergic Acid Diethylamide, Mescaline, and Drug-Induced Synesthesia Berit Brogaard, Dimitria Electra Gatzia Neuropathology of Drug Addictions and Substance Misuse, 2016, Volume 2, chapter 83, 890-905. http://dx.doi.org/10.1016/B978-0-12-800212-4.00083-2 Copyright © 2016 Elsevier Inc. All rights reserved INTRODUCTION Synesthesia typically involves either the stimulation of one sensory modality giving rise to an experience in a different sensory modality (such as when a smell or taste gives rise to a color experience) or the stimulation of a single sensory modality giving rise to an unusual qualitative experience (such as when an achromatic grapheme appears colored) (Baron-Cohen, Wyke, & Binnie, 1987; Brogaard, 2012; Cytowic, 1989; Day, 2005; Rich & Mattingley, [...]
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