Chapter 1 : You Have a Constitutional Right to Psychedelics. Academic Freedom, Personal Conscience, and Psychotechnologies Thomas B. Roberts From: Ellens, H. J. & T. B. Roberts. 2015. The Psychedelic Policy Quagmire: Health, Law, Freedom, and Society. Santa Barbara, CA. ABC-CLIO. Author’s note: This also applies to the European Charter of Human Rights and to similar national and international statements. Added Mar. 16, 2016. The problem : we do not suppress books and the ideas they contain; we do suppress psychedelic mindstates and the ideas they contain. Censorship is the issue of contention here: intellectual censorship. In this chapter, we’ll spot the single-state fallacy as [...]
Lire la suitePsilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers Boris B Quednow, Michael Kometer, Mark A Geyer and Franz X Vollenweider Neuropsychopharmacology, 2012, 37, 630–640 doi:10.1038/npp.2011.228 The serotonin-2A receptor (5-HT2AR) has been implicated in the pathogenesis of schizophrenia and related inhibitory gating and behavioral inhibition deficits of schizophrenia patients. The hallucinogen psilocybin disrupts automatic forms of sensorimotor gating and response inhibition in humans, but it is unclear so far whether the 5-HT2AR or 5-HT1AR agonist properties of its bioactive metabolite psilocin account for these effects. Thus, we investigated whether psilocybin-induced deficits in automatic and controlled inhibition in healthy [...]
Lire la suiteUse of Marijuana, Meth, Hallucinogens Up in New SAMHSA Survey Damian McNamara Medscape - Aug 22, 2019 Medscape Medical News © 2019 https://www.medscape.com/viewarticle/917131?nlid=131240_2052&src=WNL_mdplsnews_190823_mscpedit_psyc&uac=292598PZ&spon=12&impID=2070816&faf=1 Almost 1 million more Americans ages 12 or older reported using marijuana in their lifetime in 2018 than in 2017, according to new data from a national survey. The Substance Abuse and Mental Health Services Administration (SAMHSA) 2018 National Survey on Drug Use and Health Report notes that approximately 1.2 million more people reported use of hallucinogens, which include LSD, PCP, and Ecstasy, compared with 2017. In addition, about 170,000 more people used methamphetamine. Not all substance use increased year over year. For example, 187,000 fewer adolescent and adult Americans [...]
Lire la suitePsilocybin, Lysergic Acid Diethylamide, Mescaline, and Drug-Induced Synesthesia Berit Brogaard, Dimitria Electra Gatzia Neuropathology of Drug Addictions and Substance Misuse, 2016, Volume 2, chapter 83, 890-905. http://dx.doi.org/10.1016/B978-0-12-800212-4.00083-2 Copyright © 2016 Elsevier Inc. All rights reserved INTRODUCTION Synesthesia typically involves either the stimulation of one sensory modality giving rise to an experience in a different sensory modality (such as when a smell or taste gives rise to a color experience) or the stimulation of a single sensory modality giving rise to an unusual qualitative experience (such as when an achromatic grapheme appears colored) (Baron-Cohen, Wyke, & Binnie, 1987; Brogaard, 2012; Cytowic, 1989; Day, 2005; Rich & Mattingley, [...]
Lire la suiteThe Potential of Cannabidiol as a Treatment for Psychosis and Addiction : Who Benefits Most ? A Systematic Review Albert Batalla, Hella Janssen, Shiral S. Gangadin and Matthijs G. Bossong Journal of Clinical Medicine, 2019, 8, 1058 doi : 10.3390/jcm8071058 Abstract : The endogenous cannabinoid (eCB) system plays an important role in the pathophysiology of both psychotic disorders and substance use disorders (SUDs). The non-psychoactive cannabinoid compound, cannabidiol (CBD) is a highly promising tool in the treatment of both disorders. Here we review human clinical studies that investigated the ecacy of CBD treatment for schizophrenia, substance use disorders, and their comorbidity. In particular, we examined [...]
Lire la suiteNabiximols combined with motivational enhancement/cognitive behavioral therapy for the treatment of cannabis dependence : A pilot randomized clinical trial Jose M. Trigo, Alexandra Soliman, Lena C. Quilty, Benedikt Fischer, JuÈrgen Rehm, Peter Selby, Allan J. Barnes11¤a, Marilyn A. Huestis, Tony P. George, David L. Streiner, Gregory Staios, Bernard Le Foll PLoS ONE, 2018, 13, (1), e0190768. https://doi.org/10.1371/journal.pone.0190768 Abstract Background The current lack of pharmacological treatments for cannabis use disorder (CUD) warrants novel approaches and further investigation of promising pharmacotherapy. We previously showed that nabiximols (27 mg/ml Δ9-tetrahydrocannabinol (THC)/ 25 mg/ml cannabidiol (CBD), Sativex®) can decrease cannabis withdrawal symptoms. Here, we assessed in a pilot study the [...]
Lire la suiteAnandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats Marcello Solinas, Zuzana Justinova, Steven R. Goldberg and Gianluigi Tanda Journal of Neurochemistry, 2006, 98, 408–419. doi:10.1111/j.1471-4159.2006.03880.x Abstract Although endogenous cannabinoid systems have been implicated in the modulation of the rewarding effects of abused drugs and food, little is known about the direct effects of endogenous ligands for cannabinoid receptors on brain reward processes. Here we show for the first time that the intravenous administration of anandamide, an endogenous ligand for cannabinoid receptors, and its longer-lasting synthetic analog methanandamide, increase the extracellular dopamine [...]
Lire la suitePsychedelic Elephant A critique of psychedelic research Peter Webster juillet 2019 https://www.researchgate.net/search.Search.html?type=researcher&query=Psychedelic%20Elephant My title might lead some who are old enough to remember the incident 1 2 to expect from this essay an indictment of the idiots who conducted the "scientific research" during which an elephant was clearly murdered.3 It is always great fun to expose foolishness and willful ignorance. But unfortunately, psychedelic research in those days, the 1950s and 1960s, attracted no small number of other scientists who, at least in retrospect, could also be called idiots. Jean Houston (1967) has described one of her initial observations of LSD administration. The subject was told by [...]
Lire la suiteIntegrating Psychedelic Medicines and Psychiatry : Theory and Methods of a Model Clinic Jordan Sloshower Chapter 7, In : Labate B., Cavnar C. (eds) : Plant Medicines, Healing and Psychedelic Science, 2018 © Springer International Publishing AG 2018 DOI: 10.1007/978-3-319-76720-8_7 Abstract The past two decades has seen a significant increase in both popular and scientific interest in psychedelic substances and plants as therapeutics for mental illness, addictions, and psychospiritual suffering. Current psychiatric practice privileges a biological paradigm in which the brain is considered the locus of mental illness and symptom-focused treatments are delivered to patients as passive recipients. In contrast, a psychedelic healing paradigm, constructed through [...]
Lire la suiteExpanding the Scientific Study of Self-Experience with Psychedelics Manesh Girn and Kalina Christoff Journal of Consciousness Studies, 2018, 25, (11–12), 131–54 Abstract : The nature of the self has long been a topic of discussion in philosophical and religious contexts, and has recently also garnered significant scientific attention. Although evidence exists to suggest the multifaceted nature of self-experience, the amount of research done on each of its putative components has not been uniform. Whereas selfreflective processing has been studied extensively, non-reflective aspects of self-experience have been the subject of comparatively little empirical research. This discrepancy may be linked to the methodological difficulties in experimentally [...]
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