The antiaddictive effects of ibogaine : A systematic literature review of human studies Rafael G. DOS SANTOS, José Carlos BOUSO and Jaime E. C. HALLAK Journal of Psychedelic Studies, 2017, 1, (1), pp. 20–28 DOI: 10.1556/2054.01.2016.001 Background and aims : Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Methods : Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases [...]
Lire la suiteDetoxification from methadone using low, repeated, and increasing doses of ibogaine : A case report CLARE WILKINS, RAFAEL G. DOS SANTOS, JORDI SOLÁ, MARC AIXALÁ, PEP CURA, ESTEFANÍA MORENO, MIGUEL ÁNGEL ALCÁZAR-CÓRCOLES, JAIME E. C. HALLAK and JOSÉ CARLOS BOUSO Journal of Psychedelic Studies, 2017, 1, (1), pp. 29–34 DOI: 10.1556/2054.01.2017.005 Background and aims : Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, [...]
Lire la suiteAnxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder : A case report Rafael G. DOS SANTOS, Flavia L. OSÓRIO, José Alexandre S. CRIPPA and Jaime E. C. HALLAK Journal of Psychedelic Studies, 2017, 1, (1), pp. 35–39 DOI: 10.1556/2054.01.2017.004 Background and aims : Ayahuasca is a dimethyltryptamine- and β-carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods [...]
Lire la suiteSubjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning ALAN K. DAVIS, JOSEPH P. BARSUGLIA, MARLEY WINDHAM-HERMAN, MARTA LYNCH and MARTIN POLANCO Journal of Psychedelic Studies, 2017, 1, (2), pp. 65–73 DOI: 10.1556/2054.01.2017.009 Background and aims : Very few studies have reported the effectiveness of ibogaine as a treatment for chronic opioid use. Therefore, this study evaluated the acute subjective effects of ibogaine, outcomes on problematic opioid consumption, and the long-term associations with psychological functioning. Methods : Using online data collection, 88 patients who received ibogaine treatment in Mexico between 2012 and 2015 completed our survey. Results : [...]
Lire la suiteMolecular Targets of the Phytocannabinoids-A Complex Picture Paula Morales, Dow P. Hurst, Patricia H. Reggio Progress in the Chemistry of Organic Natural Products, 2017 ; 103: 103–131. doi:10.1007/978-3-319-45541-9_4. 1 Introduction For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. Phytocannabinoids are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis, including two compounds, (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC) and (−)-trans-Δ8-THC (Δ8-THC) that have been shown to bind to cannabinoid receptors and elicit the characteristic psychotropic effect associated with Cannabis [1]. [...]
Lire la suiteMolecular Pharmacology of Phytocannabinoids Sarah E. Turner, Claire M. Williams, Leslie Iversen, and Benjamin J. Whalley © Springer International Publishing Switzerland 2017 A.D. Kinghorn, H. Falk, S. Gibbons, J. Kobayashi (eds.), Phytocannabinoids, Progress in the Chemistry of Organic Natural Products 103, 61-100. DOI 10.1007/978-3-319-45541-9_3 Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [...]
Lire la suiteChemical evidence for the use of multiple psychotropic plants in a 1,000-year-old ritual bundle from South America Melanie J. Miller, Juan Albarracin-Jordan, Christine Moore, and José M. Capriles PNAS June 4, 2019, 116 (23) 11207-11212; first published May 6, 2019 https://doi.org/10.1073/pnas.1902174116 Significance Humans have a long history of using natural resources, especially plants, to induce nonordinary states of consciousness. Imbibing substances derived from plants have been linked to ancient and elaborate knowledge systems and rituals. While archaeological evidence of the consumption of psychotropics, such as alcohol or caffeine, dates back thousands of years, evidence of the use of other psychoactive substances has been more [...]
Lire la suiteThe origins of cannabis smoking : Chemical residue evidence from the first millennium BCE in the Pamirs Meng Ren, Zihua Tang, Xinhua Wu, Robert Spengler, Hongen Jiang, Yimin Yang, Nicole Boivin Science Advances, 2019, 5 : eaaw1391 (12 June 2019) DOI: 10.1126/sciadv.aaw1391 Cannabis is one of the oldest cultivated plants in East Asia, grown for grain and fiber as well as for recreational, medical, and ritual purposes. It is one of the most widely used psychoactive drugs in the world today, but little is known about its early psychoactive use or when plants under cultivation evolved the phenotypical trait of increased specialized compound production. [...]
Lire la suitePhytochemical and genetic analyses of ancient cannabis from Central Asia Ethan B. Russo, Hong-En Jiang, Xiao Li, Alan Sutton, Andrea Carboni, Francesca del Bianco, Giuseppe Mandolino, David J. Potter, You-Xing Zhao, Subir Bera, Yong-Bing Zhang, En Guo Lu, David K. Ferguson, Francis Hueber, Liang-Cheng Zhao, Chang-Jiang Liu, Yu-Fei Wang and Cheng-Sen Li Journal of Experimental Botany, 2008, Vol. 59, No. 15, pp. 4171–4182, doi:10.1093/jxb/ern260 Abstract The Yanghai Tombs near Turpan, Xinjiang-Uighur Autonomous Region, China have recently been excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions. A multidisciplinary international [...]
Lire la suiteA reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products Qingfang Meng, Beth Buchanan, Jonathan Zuccolo, Mathieu-Marc Poulin, Joseph Gabriele, David Charles Baranowski PLoS ONE, 2018, 13, 5, e0196396. https://doi.org/10.1371/journal.pone.0196396 Abstract In the past 50 years, Cannabis sativa (C. sativa) has gone from a substance essentially prohibited worldwide to one that is gaining acceptance both culturally and legally in many countries for medicinal and recreational use. As additional jurisdictions legalize Cannabis products and the variety and complexity of these products surpass the classical dried plant material, appropriate methods for measuring the biologically active constituents is paramount to ensure [...]
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