“To learn healing knowledge”: Philosophy, psychedelic studies and transformation David A. Pittaway South African Journal of Philosophy, 2018, 37, 4, 438-451 DOI : 10.1080/02580136.2018.1532186 Abstract : “Philosophical learning” may be summarised in Sobiecki’s fitting catchphrase “to learn healing knowledge”. This catchphrase is taken from an article on the use of psychoactive plants among southern African diviners. In the spirit of this link, I aim to challenge contemporary negative attitudes to the topic of psychedelics, and argue that there are good reasons for philosophers to pay attention to the role that the psychedelic experience can play in promoting philosophical perception. I argue first that the results [...]
Lire la suiteInvestigational Cannabinoids in Seizure Disorders, what have we learned thus far ? Dejana Ružić Zečević, Ziyad Tantoush, Marko Folić, Goran Babić, Milan Radovanović and Slobodan M. Janković may 2018, 23 pages ABSTRACT Introduction : Anticonvulsant activity of cannabinoid attracted much attention in the last decade. Cannabinoids that are currently investigated with intention to become drugs for treatment of epilepsy are cannabidiol, cannabidivarin, Δ9-tetrahydrocannabivarin and Δ9-tetrahydrocannabinolic acid. Areas covered : Topic of this review are results of pre-clinical and clinical studies with investigational cannabinoids. Relevant literature was searched for in MEDLINE, SCOPUS, EBSCO, GOOGLE SCHOLAR and SCINDEX databases. Expert opinion : Pre-clinical studies confirmed anticonvulsant activity of [...]
Lire la suitePRÉ-PROGRAMME : USAGES CLINIQUES des CANNABINOÏDES 24es PROFESSIONNELLES RENCONTRES DU RESPADD RÉSEAU DES ÉTABLISSEMENTS DE SANTÉ POUR LA PRÉVENTION DES ADDICTIONS En collaboration avec le GRECC (Groupe de Recherche et d’Etudes Cliniques sur les Cannabinoïdes) 20 et 21 JUIN 2019 PARIS ESPACE DU CENTENAIRE Quai de la Rapée 75012 Paris 9h30 – Accueil 10h00-12h30> Session Groupe de Recherche et d’Etudes Cliniques sur les Cannabinoïdes Président de séance : Christian Sueur, président du GRECC 10h00 – 10h30> Ouverture Ville de Paris, (sous réserve) ARS Ile-de-France, (sous réserve) Christian Sueur, président du GRECC 10h30 – 12h30 ÉTAT DES LIEUX DES ESSAIS CLINIQUES SUR LES CANNABINOÏDES EN FRANCE Discutant : Rodolphe Ingold, GRECC > Utilisation du Marinol en France : enquête [...]
Lire la suite#INSIGHT 2019 - Integrating science and practice of psychedelic states: International Conference (Sept 5th-7th, Berlin) INSIGHT 2019 - International Conference in Berlin: New Website online The INSIGHT 2019 conference website launched! Get your tickets now. Great international line-up (more to come). Tracks: Basic research, Therapy, Public Health, Philosophy at the Langenbeck-Virchow House Berlin-Mitte. https://insight-conference.eu #INSIGHT2019 #MINDacademy #Berlin Research about the psychedelic state and its applications in medical and other contexts has entered a new phase. Dozens of international Universities are involved in basic, clinical and public health research about classical psychedelics, novel substances and the contexts that facilitate positive, sustainable or negative outcomes. The [...]
Lire la suiteCannabinoïde Signaling in the Skin : Therapeutic Potential of the “C(ut)annabinoid” System Kinga Fanni Tóth, Dorottya Ádám, Tamás Bíró, and Attila Oláh Molecules 2019, 24(5), 918; https://doi.org/10.3390/molecules24050918 Abstract : The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are [...]
Lire la suiteStreets of the ‘spice zombies’: Dependence and poverty stigma in times of austerity Liviu Alexandrescu School of History, Philosophy and Culture, Oxford Brookes University Crime Media Culture, 2019 Abstract Following the 2016 general ban on new psychoactive substances, synthetic cannabinoids (‘spice’-type drugs) have moved into unregulated street markets and have become popular among homeless populations in the United Kingdom. Images of so-called ‘spice zombies’, rough sleepers in public spaces experiencing severe substance-induced fits, have been used by local and national media to suggest the growing scale of the problem. This article proposes that such depictions should be read through a cultural analysis rooted in the [...]
Lire la suiteAssociation of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood - A Systematic Review and Meta-analysis Gabriella Gobbi, Tobias Atkin, Tomasz Zytynski, Shouao Wang, Sorayya Askari, Jill Boruff, Mark Ware, Naomi Marmorstein, Andrea Cipriani, Nandini Dendukuri, Nancy Mayo JAMA Psychiatry, 2019, 76, 4, 426-434. doi:10.1001/jamapsychiatry.2018.4500 Published online February 13, 2019. Corrected on March 13, 2019. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2723657?guestAccessKey=c2ffca43-46c1-4563-8949-c1625bfbdefa&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetwork&utm_content=weekly_highlights&utm_term=051919 IMPORTANCE : Cannabis is the most commonly used drug of abuse by adolescents in the world. While the impact of adolescent cannabis use on the development of psychosis has been investigated in depth, little is known about the impact of cannabis use on mood [...]
Lire la suiteA Phase I, Randomized, Double‑Blind, Placebo‑Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects Lesley Taylor,·Barry Gidal,·Graham Blakey, Bola Tayo, Gilmour Morrison CNS Drugs, 2018 https://doi.org/10.1007/s40263-018-0578-5 Abstract Background : A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters. Objective : This trial assessed the safety, tolerability and PK of CBD oral solution in healthy adult volunteers, as well as the effect [...]
Lire la suiteEfficacy and safety of ketamine in bipolar depression : A systematic review Susana Alberich, Mónica Martínez-Cengotitabengoa, Purificación López, Inaki Zorrilla, Nuria Núnez, Eduard Vieta, Ana González-Pinto, Review Psiquiatrica Salud Mental, 2017, 10, 2, 104-112. 2173-5050/© 2016 SEP y SEPB. Published by Elsevier Espana, S.L.U. All rights reserved. KEYWORDS : Bipolar depression; Ketamine; Efficacy Abstract : The depression is the most prevalent state throughout the life of the bipolar patient. Ketamine has been shown to be an effective and rapid treatment for depression. The objective of the present work is to perform a systematic review on the efficacy and safety of ketamine as treatment of bipolar depression, [...]
Lire la suiteModulation of acute effects of delta-9-tetrahydrocannabinol on psychotomimetic effects, cognition and brain function by previous cannabis exposure Marco Colizzi, Philip McGuire, Vincent Giampietro, Steve Williams, Mick Brammer, Sagnik Bhattacharyya, European Neuropsychopharmacology, 2018, 28, 850-862. https://doi.org/10.1016/j.euroneuro.2018.04.003 0924-977X/ ©2018 ElsevierB.V. and ECNP. All rights reserved. KEYWORDS : Cannabis use; Delta-9-tetrahydrocannabinol; Functional Magnetic Resonance Imaging; Cognitive functioning; Tolerance; Psychosis Abstract Cannabis use has been associated with psychosis and cognitive dysfunction. Some evidence suggests that the acute behavioral and neurocognitive effects of the main activei ngredient in cannabis, (-)-trans-Δ9 tetrahydrocannabinol (Δ9-THC), might be modulated by previous cannabis exposure. However, this has not been investigated either using a control group of non-users, [...]
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