Maître Ingrid Metton: La pénaliste du Cannabis Elle devient l’unique espoir d’en sortir, pour ceux que la justice enferme et punit parce qu’ils ont possédé, transporté, consommé ou même cultivé du Cannabis, que ce soit ou pas dans le but de se soigner. C’est celle, qui défend aujourd’hui de nombreux commerçants aux prises avec la justice pour avoir vendu des fleurs chanvre et des produits dérivés. Comme elle s’exprime très peu dans les média, sa parole est rare mais son discours percutant. Nous sommes allés à la rencontre de Maître Ingrid Metton, Avocate pénaliste. En exclusivité pour Le Cannabiste. Interview réalisée le 19 Juillet [...]
Lire la suiteSéminaire EHESS "études psychédéliques, approche historique" 12, Nov Cet atelier doctoral de l'EHESS (Centre Alexandre-Koyré), ouvert aux étudiant·e·s, doctorant·e·s et chercheur·e·s, propose un programme de conférences portant sur le thème des substances dites « psychédéliques », selon terme inventé en 1956 par le psychiatre britannique Humphry Osmond. Il s’agit de proposer une étude historique de l'intérêt scientifique portant sur la mescaline, le LSD et la psilocybine, des recherches portant sur leurs effets psychiques et sur leur utilité en thérapeutique, des aspects liés à leur production et enfin de leur réception en dehors du monde académique. Chaque séance est structurée [...]
Lire la suiteHistoire de la découverte de quelques hallucinogènes science DE L’USAGE DE QUELQUES PLANTES HALLUCINOGÈNES, chez les voyageurs, les écrivains, les artistes et les médecins par Aymon de Lestrange Pour citer cet article : de l’Estrange, Aymon, 2018, Histoire de la découverte de quelques hallucinogènes, https://societepsychedelique.fr/fr/blog/histoire-de-la-decouverte-de-quelque-hallucinogenes , septembre 2018, consulté le... L’usage rituel et médical de stupéfiants tels que l’opium ou le haschisch remonte à plusieurs millénaires. Il en va de même pour les hallucinogènes tels que le peyotl ou bien les champignons hallucinogènes, à ceci près que leur découverte par l’Occident a été beaucoup plus tardive. On estime à plusieurs centaines le nombre d’espèces de [...]
Lire la suiteTerpenes HAPA Medical web site, 2019 https://www.hapa-medical.com/medical-cannabis/phyto-cannabinoids/terpene Terpenes form the main component of a plant’s essential oils and account for its characteristic smell and taste. Terpenes also appear to be important for the precise regulation of cannabis pharmacology by e.g. modulating GABAergic neurotransmission. Preliminary results indicate that cannabis terpenes could play a significantly greater therapeutic role as initially presumed, however more research is still required. Here is an overview of the most commonly-occurring terpenes in cannabis and their postulated medicinal effects. Terpenes form the main component of a plant’s essential oils, and over 8,000 different terpenes have been identified to date. They account for [...]
Lire la suiteCannabinoid Receptor 2 Signaling in Neurodegenerative Disorders : From Pathogenesis to a Promising Therapeutic Target Tommaso Cassano, Silvio Calcagnini, Lorenzo Pace, Federico De Marco, Adele Romano and Silvana Gaetani Frontiers in Neuroscience, 2017, 11, article 30 DOI : 10.3389/fnins.2017.00030 Abstract : As a consequence of an increasingly aging population, the number of people affected by neurodegenerative disorders,such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, is rapidly increasing. Although the etiology of these diseases has not been completely defined, common molecular mechanisms including neuroinflammation, excitotoxicity and mitochondrial dysfunction have been confirmed and can be targeted therapeutically. Moreover, recent studies have shown that endogenous cannabinoid signaling [...]
Lire la suiteCBG & others HAPA Medical web site , 2019 https://www.hapa-medical.com/medical-cannabis/phyto-cannabinoids/cbg-others In addition to the most well-known phytocannabinoids THC and CBD, cannabis contains more than 100 other phytocannabinoids which could have therapeutic properties. In this article you will find an overview of the most well-known and commonly-occurring ones: cannabigerol (CBG), beta-caryophyllene (BCP), cannabidivarin (CBDV), cannabinol (CBN), cannabichromene (CBC) and tetrahydrocannabivarin (THCV). These active compounds (and terpenes) are absent in cannabinoid isolates, however in full-spectrum extracts they are present in varying proportions of course, which means that a possible entourage effect of the substances can be exploited. In addition to the most well-known phytocannabinoids THC and [...]
Lire la suiteA Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology Lisa M. Eubanks, Claude J. Rogers, Albert E. Beuscher IV, George F. Koob, Arthur J. Olson, Tobin J. Dickerson, and Kim D. Janda Molecular Pharmacology, 2006, 3, 6, 773–777. doi:10.1021/mp060066m Abstract : Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years. Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients as well as reduce [...]
Lire la suiteSymptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease C. García, C. Palomo-Garo, M. Garcia-Arencibia, J.A. Ramos, R.G. Pertwee, J. Fernandez-Ruiz British Journal of Pharmacology, 2011, 163, 1495-1506. (Themed Issue : Cannabinoids on Biology and Medicine, Part 1) DOI : 10.1111/j.1476-5381.2011.01278.x Abstract BACKGROUND AND PURPOSE Previous findings have indicated that a cannabinoid, such as Δ9-THCV, which has antioxidant properties and the ability to activate CB2 receptors but to block CB1, might be a promising therapy for alleviating symptoms and delaying neurodegeneration in Parkinson's disease (PD). EXPERIMENTAL APPROACH The ability of Δ9-THCV to reduce motor inhibition and provide neuroprotection was investigated in rats lesioned with [...]
Lire la suiteBiphasic effects of THC in memory and cognition Edward J. Calabrese, Alberto Rubio-Casillas European Journal of Clinical Investigation, 2018, 48, e12920. DOI: 10.1111/eci.12920 Abstract : A generally undesired effect of cannabis smoking is a reversible disruption of short-term memory induced by delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, this paradigm has been recently challenged by a group of scientists who have shown that THC is also able to improve neurological function in old animals when chronically administered at low concentrations. Moreover, recent studies demonstrated that THC paradoxically promotes hippocampal neurogenesis, prevents neurodegenerative processes occurring in animal models of Alzheimer’s disease, protects from inflammationinduced [...]
Lire la suiteA chronic low dose of Δ9 tetrahydrocannabinol (THC) restores cognitive function in old mice Andras Bilkei-Gorzo, Onder Albayram, Astrid Draffehn, Kerstin Michel, Anastasia Piyanova, Hannah Oppenheimer, Mona Dvir-Ginzberg, Ildiko Rácz, Thomas Ulas, Sophie Imbeault, Itai Bab, Joachim L Schultze & Andreas Zimmer Nature Medicine, 2017, 23, 782-787. DOI : 10.1038/nm.4311 Abstract : The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging. The activity of the ECS declines during aging, as CB1 receptor expression [...]
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